π-Conjugated polyelectrolytes (CPEs) constitute an emerging class of (nano)materials, as these combine solubility in water and the unique optoelectronic properties of the π-conjugated polymer backbone, with prospective applications in biosensing and medical diagnosis.
During this seminar, we will particularly emphasize the binding and self-assembly mechanisms of DNA with CPEs, which have been overlooked in the design of CPE-based biosensors. Importantly, we will show that DNA sequence-specific interactions are at play upon the self-assembly with CPE, related to conformational chirality of the polymer backbone within the complexes. Moreover, we establish the mechanisms of DNA-DNA hybridization in complexes, which strongly depend on the DNA sequences. This constitutes a step forward towards a rational design of DNA-CPE materials for biosensing applications.
References
J. Rubio-Magnieto, et al., Chem. Commun. 2013, 49, 5483.
J. Rubio-Magnieto, et al., Soft Matter 2015, 11, 6460.
Contact local ICGM : Dr. Sébastien Clément (équipe CMOS)