Accueil > La recherche > Les Equipes > Glycochemistry and Molecular Recognition

Publications (2012-present)

par Sebastien Ulrich - publié le , mis à jour le

2019

Growing Prospects of Dynamic Covalent Chemistry in Delivery Applications. S. Ulrich, Acc. Chem. Res., 2019, in press (DOI 10.1021/acs.accounts.8b00591). Link


(Hetero)aryl substituted thiazol-2,4-yl scaffold as human carbonic anhydrase I, II, VII and XIV activators. M. Rami, J-Y. Winum, C.T. Supuran, P. Melnyk, S. Yous, J. Enzyme Inhib. Med. Chem., 2019, 34, 224-229. Link


2018

Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases : An Update on In Vitro and In Vivo Studies. A. Aspatwar, J-Y. Winum, F. Carta, C.T. Supuran, M. Hammaren, M. Parikka, S. Parkkila, Molecules., 2018, 23(11), E2911. link


Inhibition of carbonic anhydrases by a substrate analog : benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding. G. De Simone, A. Angeli, M. Bozdag, C.T. Supuran, J-Y. Winum, S.M. Monti, V. Alterio, Chem. Commun., 2018, 54(73), 10312-10315. link


Biomolecular Dynamic Covalent Polymers for DNA complexation and siRNA delivery. C. Bouillon, Y. Bessin, F. Poncet, M. Gary-Bobo, P. Dumy, M. Barboiu, N. Bettache, S. Ulrich, J. Mater. Chem. B., 2018, 7239-7246. link


Multivalent metallosupramolecular assemblies as effective DNA binding agents. W. Drożdż, A. Walczak, Y. Bessin, V. Gervais, X.‐Y. Cao, J.‐M. Lehn, S. Ulrich, A. R. Stefankiewicz, Chem. Eur. J., 2018, 24, 10802-10811. link


Auto-assemblages dynamiques pour la reconnaissance et la vectorisation d’acides nucleiques. S. Ulrich, L’Actualité Chimique, 2018, 430-431, 61-67. link


Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes. A. Aspatwar, H.M. Becker, N.K. Parvathaneni, M. Hammaren, A. Svorjova, H. Barker, C.T. Supuran, L. Dubois, P. Lambin, M. Parikka, S. Parkkila, J-Y Winum, J. Enzyme Inhib. Med. Chem., 2018, 33(1), 1064-1073. link


Carbonic anhydrase enzymes for regulating mast cell hematopoiesis and type-2 inflammation : a patent evaluation (WO2017/058370). J-Y Winum, Expert Opin. Ther. Pat., 2018, 28(10), 741-743. link


Benzoxaborole compounds for therapeutic uses : a patent review (2010- 2018). A. Nocentini, C.T. Supuran, J-Y Winum, Expert Opin. Ther. Pat., 2018, 28 (6), 493-504. link


Self-assembly and chiroptical properties in supramolecular complexes of adenosine phosphates and guanidinium-bispyrene. M. Trévisan, M. Fossépré, D. Paolantoni, J. Rubio‐Magnieto, P. Dumy, S. Ulrich, M. Surin, Chirality, 2018, 30 (6), 719-729. link


Inhibitors of Selected Bacterial Metalloenzymes. R. Zalubovskis, J-Y Winum, Curr. Med. Chem., 2018, in press. doi : 10.2174/0929867325666180403154018. link


Switching multivalent DNA complexation using metallo-controlled cationic supramolecular self-assemblies. W. Drożdż, Y. Bessin, V. Gervais, X.-Y. Cao, J.-M. Lehn, A. R. Stefankiewicz, S. Ulrich, Chem. Eur. J., 2018, 24 (7), 1518-1521. link


Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles. A. Nocentini , R. Cadoni, P. Dumy, CT. Supuran, J-Y Winum, J. Enzyme Inhib. Med. Chem., 2018, 33 (1), 286-289. link


Photomodulation of DNA-templated supramolecular assemblies. J. Rubio-Magnieto, T.-A. Phan, M. Fossépré, V. Matot, J. Knoops, T. Jarrosson, P. Dumy, F. Serein-Spirau, C. Niebel, S. Ulrich, M. Surin, Chem. Eur. J., 2018, 24 (3), 706-714. link


Co-targeting intracellular pH and essential amino acid uptake cooperates to induce cell death of T-ALL/LL cells. V. Imbert, M. Nebout, D. Mary, H. Endou, MF. Wempe, CT. Supuran, J-Y. Winum, J-F. Peyron, Leuk. Lymphoma, 2018, 59 (2), 460-468. link


2017

Generation of Multicomponent Molecular Cages using Simultaneous Dynamic Covalent Reactions. W. Drożdż, C. Bouillon, C. Kotras, S. Richeter, M. Barboiu, S. Clément, A. R. Stefankiewicz, S. Ulrich, Chem. Eur. J., 2017, 23, 18010-18018. link


Benzoxaboroles as Efficient Inhibitors of the β-Carbonic Anhydrases from Pathogenic Fungi : Activity and Modeling Study. A. Nocentini, R. Cadoni, S. del Prete, C. Capasso, P. Dumy, P. Gratteri, C.T. Supuran, J-Y. Winum, ACS Med. Chem. Lett., 2017, 8 (11), 1194-1198. link


Polyhedral oligomeric silsesquioxane (POSS) bearing glyoxylic aldehyde as clickable platform towards multivalent conjugates. N. Kanfar, A. Mehdi, P. Dumy, S. Ulrich, J.-Y. Winum, Chem. Eur. J., 2017, 23, 17867-17869. link


One-Pot Self-Assembly of Peptide-Based Cage-Type Nanostructures using Orthogonal Ligations. E. Bartolami, J. Knoops, Y. Bessin, M. Fossépré, J. Chamieh, P. Dumy, M. Surin, S. Ulrich, Chem. Eur. J., 2017, 23, 14323-14331. link


New approach of delivering cytotoxic drugs towards CAIX expressing cells : A concept of dual-target drugs. S. Van Kujik, N-K. Parvathaneni, R. Niemans, MW. Van Gisbergen, F. Carta, D. Vullo, S. Pastorekova, A. Yaromina, C.T. Supuran, L. Dubois, J-Y. Winum, P. Lambin, Eur. J. Med. Chem., 2017, 127, 691-702. link


Brucella suis carbonic anhydrases and their inhibitors : towards alternative antibiotics ? S. Kohler, S. Ouahrani-Bettache, J-Y. Winum, J. Enzyme Inhib. Med. Chem., 2017, 32, 683-687. link


Anion inhibitors of the beta-carbonic anhydrase from the pathogenic bacterium responsible of tularemia, Francisella tularensis. S. Del Prete, D. Vullo, S.M. Osman, Z. Alothman, W.A. Donald, J-Y. Winum, C.T. Supuran, C. Capasso, Bioorg. Med. Chem., 2017, 25 (17), 4800-4804. link


Insights into the binding mode of sulfamates and sulfamides to hCA II : crystallographic studies and binding free energy calculations. G. De Simone, E. Langella, D. Esposito, C.T. Supuran, S.M. Monti, J-Y. Winum, V. Alterio, J. Enzyme Inhib. Med. Chem., 2017, 32, 1002-1011. link


Effective Access to Multivalent Inhibitors of Carbonic Anhydrases Promoted by Peptide Bioconjugation. N. Kanfar, M. Tanc, P. Dumy, C. T. Supuran, S. Ulrich, J.-Y. Winum, Chem. Eur. J., 2017, 23 (28), 6788-6794. link


SuFEx : a metal-free click ligation for multivalent biomolecules. A. Marra, A. Dondoni, Org. Biomol. Chem., 2017, (15), 1549-1553. link


Auto-assemblage dynamique de clusters cationiques pour la complexation et la vectorisation d’acides nucléiques. E. Bartolami, S. Ulrich, P. Dumy, L’Actualité Chimique, 2017, 417. link


2016

DNA Methyltransferase Inhibitors : Development and Applications. M. Lopez, L. Halby, P. B. Arimondo, Advances in Experimental Medicine and Biology, 2016, 945, 431-473. link


« Drug Discovery Methods ». M. Lopez, M. Leroy, C. Etievant, F. Ausseil, A. Gagnon, P. B. Arimondo, In G. Egger & P. Arimondo (Eds), Drug Discovery in Cancer Epigenetics, Elsevier, 2016, 63-95. link


Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution. C. S. Hwang, L. Xu, W. Wang, S. Ulrich, L. Zhang, J. Chong, J. H. Shin, X. Huang, E. T. Kool, C. E. McKenna, D. Wang, Nucl. Acids Res., 2016, 44 (8), 3820-3828. link


Bioactive clusters promoting cell penetration and nucleic acids complexation for drug and gene delivery applications : from designed to self-assembled and responsive systems. E. Bartolami, C. Bouillon, P. Dumy, S. Ulrich, Chem. Commun., 2016, 52, 4257-4273. link


A click ligation based on SuFEx for the metal-free synthesis of sugar and iminosugar clusters. R. Zelli, S. Tommasone, P. Dumy, A. Marra, A. Dondoni, Eur. J. Org. Chem., 2016, 5102-5116. link


Role of a preorganized scaffold presenting four residues of a GM‐3 lactone mimetic on Melanoma progression. B. Richichi, G. Comito, O. Renaudet, M. Fiore, A. Marra, B. Stecca, L. Pasquato, P. Chiarugi, C. Nativi, ACS Med. Chem. Lett., 2016, (7), 28-33. link


A metal-free synthetic approach to peptide-based iminosugar clusters as novel multivalent glycosidase inhibitors. R. Zelli, E. Bartolami, J.-F. Longevial, Y. Bessin, P. Dumy, A. Marra, S. Ulrich, RSC Adv., 2016, 6, 2210-2216. link


The anticonvulsant sulfamide JNJ-26990990 and its S, S - dioxide analog strongly inhibit carbonic anhydrases : kinetic and X-ray crystallographic studies. A. Di Fiore, G. De Simone, V. Alterio, V. Riccio, J-Y. Winum, F. Carta, C-T. Supuran, Org. Biomol. Chem., 2016, 14 (21), 4853-4858. link


Benzoxaborole as a New Chemotype for Carbonic Anhydrase Inhibition. V. Alterio, R. Cadoni, D. Esposito, D. Vullo, A. Di Fiore, Sm. Monti, A. Caporale, M. Ruvo, M. Sechi, P. Dumy, Ct. Supuran, G. De Simone, J-Y. Winum, Chem. Commun., 2016, 52 (80), 11983-11986. link


Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors : a patent evaluation of US20160011199A1. J-Y. Winum, Expert Opin. Ther. Pat., 2016, 26 (11), 1223-1226. link


2015

Compounds for use in the treatment of mycobacterial infections : a patent evaluation (WO2014049107A1). D. Pechalrieu, M. Lopez, Expert Opinion on Therapeutic Patents, 2015, 25 (6), 729-735. link


Emerging trends in enzyme inhibition by multivalent nanoconstructs. N. Kanfar, E. Bartolami, R. Zelli, A. Marra, J.-Y. Winum, S. Ulrich, P. Dumy, Org. Biomol. Chem., 2015, 13, 9894-9906. link


Multivalent DNA recognition by self-assembled clusters : deciphering structural effects by fragments screening and evaluation as siRNA vectors. E. Bartolami, Y. Bessin, N. Bettache, M. Gary-Bobo, M. Garcia, P. Dumy, S. Ulrich, Org. Biomol. Chem., 2015, 13, 9427-9438 (themed collection : Multivalent Biomolecular Recognition). link


Dynamic expression of DNA complexation with self-assembled biomolecular clusters
E. Bartolami, Y. Bessin, V. Gervais, P. Dumy, S. Ulrich, Angew. Chem. Int. Ed., 2015, 54 (35), 10183-10187. link


Synthesis and biological properties of multivalent iminosugars. R. Zelli, J.-F. Longevial, P. Dumy, A. Marra, New J. Chem., 2015, (39), 5050-5074. link


Validating the alkene and alkyne hydrophosphonylation as an entry to organophosphonates. A. Dondoni, A. Marra, Org. Biomol. Chem., 2015, (13), 2212–2215. link


Metal-free synthesis of E-vinylphosphonates via photoinduced alkyne hydrophosphonylation and thiol promoted isomerization sequence. S. Staderini, A. Dondoni, A. Marra Tetrahedron Lett., 2015, (56), 374-377. link


Fluorescent silica nanoparticles with multivalent inhibitory effects towards carbonic anhydrases. N. Touisni, N. Kanfar, S. Ulrich, P. Dumy, C.T. Supuran, A. Mehdi, J.-Y. Winum, Chem. Eur. J., 2015, 21 (29), 10306-10309. link


Synthesis of a-PNA containing a functionalized triazine as nucleobase analogue, E. Bartolami, A. Gilles, P. Dumy, S. Ulrich, Tetrahedron Lett., 2015, 56 (18), 2319-2323. link


A Dynamic Combinatorial Approach for Identifying Side Groups that Stabilize DNA-Templated Supramolecular Self-Assemblies, D. Paolantoni, S. Cantel, P. Dumy, S. Ulrich, Int. J. Mol. Sci., 2015, 16, 3609-3625 (special issue « Supramolecular interactions »). link


Binding of carbonic anhydrase IX to 45s rDNA genes is prevented by exportin-1 in hypoxic cells. E. Sasso, M. Vitale, F. Monteleone, Fl. Boffo, M. Santoriello, D. Sarnataro, C. Garbi, M. Sabatella, B. Crifò, LA. Paolella, G. Minopoli, J-Y. Winum, N. Zambrano, BioMed. Res. Int., 2015, Volume 2015, Article ID 674920, 10 pages. Link


Recent advances in the discovery of zinc binding motifs for the development of carbonic anhydrase inhibitors. J-Y. Winum, CT. Supuran, J. Enzyme Inhib. Med. Chem., 2015, 30, 321-324. Link


Inhibition of β-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moiety. LE. Riafrecha, D. Vullo, S. Ouahrani-Bettache, S. Köhler, P. Dumy, J-Y. Winum, CT. Supuran, PA. Colinas, J. Enzyme Inhib. Med. Chem., 2015, 30, 1017-1020. Link


N-Glycosyl-N-Hydroxysulfamides as Potent Inhibitors of Brucella suis Carbonic Anhydrases. J. Ombouma, D. Vullo, S. Kohler, P. Dumy, CT. Supuran, J-Y. Winum, J. Enzyme Inhib. Med. Chem., 2015, 30, 1010-1012. Link


Designing carbonic anhydrase inhibitors for the treatment of breast cancer. CT. Supuran, J-Y. Winum, Expert Opin. Drug Discov., 2015, 10, 591-597. link


Poly(amidoamine) Dendrimers with Carbonic Anhydrase Inhibitory Activity and Antiglaucoma Action. F. Carta, SM. Osman, D. Vullo, A. Gullotto, J-Y. Winum, Z. Alothman, E. Masini, CT. Supuran, J. Med. Chem., 2015, 58, 4039-4045. Link


Evaluation of Carbonic Anhydrase IX as a Therapeutic Target for Inhibition of Breast Cancer Invasion and Metastasis Using a Series of in vitro Breast Cancer Models. C. Ward, J. Meehan, P. Mullen, CT. Supuran, JM. Dixon, JS. Thomas, J-Y. Winum, P. Lambin, L. Dubois, NK. Pavathaneni, EJ. Jarman, L. Renshaw, I. Um, C. Kay, IH. Kunkler, DJ. Harrison, SP. Langdon, Oncotarget, 2015, 6, 24856-24870. Link=4498&pubmed-linkout=1]


Carbonic Anhydrase Glycoinhibitors belonging to the Aminoxysulfonamide Series. J. Ombouma, D. Vullo, P. Dumy, CT. Supuran, J-Y. Winum, ACS Med. Chem. Lett., 2015, 6, 819-21. Link


Carbonic Anhydrase IX Inhibitors in Cancer Therapy : an Update. CT. Supuran, J-Y. Winum, Future Med. Chem., 2015, 7, 1407-14. link


New ways to image and target tumour hypoxia and its molecular responses. LJ. Dubois, R. Niemans, SJ. Van Kuijk, KM. Panth, NK. Parvathaneni, SG. Peeters, CM. Zegers, NH. Rekers, MW. Van Gisbergen, R. Biemans, NG. Lieuwes, L. Spiegelberg, A. Yaromina, J-Y. Winum, M. Vooijs, P. Lambin, Radiother. Oncol., 2015, 116, 352-357. link


2014

Oxo- and thiooxo-imidazo[1,5-c]pyrimidine molecule library : beyond their interest in inhibition of Brucella suis histidinol dehydrogenase, a powerful protection tool in the synthesis of histidine analogues. F. Turtaut, M. Lopez, S. Ouahrani-Bettache, S. Köhler, J.-Y. Winum, Bioorganic and Medicinal Chemistry Letters, 2014, 24, 5008-5010. link


Synthesis of sulfomanide-conjugated glycosyl-amino acid building blocks. M. Lopez, L. F. Bornaghi and S.-A. Poulsen, Carbohydrate research, 2014, 386, 78-85. link


Structural basis for the rational design of new anti-Brucella agents : the crystal structure of the C366S mutant of HDH from Brucella suis. K. D’ambrosio, M. Lopez, N. A. Dathan, S. Ouahrani-Bettache, S. Köhler, G. Ascione, S. M. Monti, J.-Y. Winum and G. De Simone, Biochimie, 2014, 97, 114-120. link


Probing the importance of π-stacking interactions in DNA-templated self-assembly of bisfunctionalized guanidinium compounds, D. Paolantoni, J. Rubio-Magnieto, S. Cantel, J. Martinez, P. Dumy, M. Surin, S. Ulrich, Chem. Commun., 2014, 50, 14257-14260. link


Degradable Hybrid Materials Based on Cationic Acylhydrazone Dynamic Covalent Polymers Promote DNA Complexation through Multivalent Interactions, C. Bouillon, D. Paolantoni, J. C. Rote, Y. Bessin, L. W. Peterson, P. Dumy, S. Ulrich, Chem. Eur. J., 2014, 20 (45), 14705-14714. link


Probing Secondary Interactions in Biomolecular Recognition by Dynamic Combinatorial Chemistry, S. Ulrich, P. Dumy, Chem. Commun., 2014, 50 (44), 5810-5825 (“Systems chemistry : a web themed issue”). link


Synthesis and glycosidase inhibition properties of triazole-linked calixarene-iminosugar clusters. A. Marra, R. Zelli, G. D’Orazio, B. La Ferla, A. Dondoni, Tetrahedron, 2014, (70), 9387-9393. link


Synthesis of galactoclusters by metal-free thiol « click chemistry » and their binding affinities for Pseudomonas aeruginosa lectin LecA. C. Ligeour, L. Dupin, A. Marra, G. Vergoten, A. Meyer, A. Dondoni, E. Souteyrand, J.-J. Vasseur, Y. Chevolot, F. Morvan, Eur. J. Org. Chem., 2014, 7621-7630. link


Thiol-ene and thiol-yne-based synthesis of glycodendrimers as nanomolar inhibitors of wheat germ agglutinin. M. Ghirardello, K. Öberg, S. Staderini, O. Renaudet, N. Berthet, P. Dumy, Y. Hed, A. Marra, M. Malkoch, A. Dondoni, J. Polym. Sci., Part A : Polym. Chem., 2014, (52), 2422-2433. link


Metal-catalyzed and metal-free alkyne hydrothiolation : Synthetic aspects and application trends. A. Dondoni, A. Marra, Eur. J. Org. Chem., 2014, 3955-3969. link


Theoretical and Structural Analysis of Long C–C Bonds in the Adducts of Polycyanoethylene and Anthracene Derivatives and their Connection to the Reversibility of Diels–Alder Reactions, A. K. H. Hirsch, P. Reutenauer, M. Le Moignan, S. Ulrich, P. J. Boul, J. M. Harrowfield, P. D. Jarowski, J.-M. Lehn, Chem. Eur. J., 2014, 20 (4), 1073-1080. link


Oxime Ligation : a Chemoselective Click-Type Reaction for Accessing Multifunctional Biomolecular Constructs, S. Ulrich, D. Boturyn, A. Marra, O. Renaudet, P. Dumy, Chem. Eur. J., 2014, 20 (1), 34-41. link


Metal-based carboxamide-derived compounds endowed with antibacterial and antifungal activity. M. Hanif, ZH. Chohan, J-Y. Winum, J. Akhtar, J. Enzyme Inhib. Med. Chem., 2014, 29, 517-26. link


Carbonic anhydrase inhibitors. Inhibition of human cytosolic isoforms I and II with (reduced) Schiff’s bases incorporating sulfonamide, carboxylate and carboxymethyl moieties. G. Nasr, A. Cristian, M. Barboiu, D. Vullo, J-Y. Winum, CT. Supuran, Bioorg. Med. Chem., 2014, 22, 2867-74. link


Dominant behaviours in the expression of human of Carbonic Anhydrase hCA I activity. MYM. Abdelarhim, AM. Tanc, J-Y. Winum, CT. Supuran, M. Barboiu, Chem. Commun., 2014, 50, 8043-8046. link


Mono and Di-Halogenated Histamine, Histidine and Carnosine Derivatives are Potent Carbonic Anhydrase I, II, VII, XII and XIV Activators. MC. Saada, D. Vullo, J-L. Montero, A. Scozzafava, CT. Supuran,J-Y. Winum, Bioorg. Med. Chem., 2014, 22, 4752-8. link


Ferrier sulfamidoglycosylation of glycals catalyzed by nitrosononium tetrafluoroborate : towards new carbonic anhydrase glycoinhibitors. J. Ombouma, D. Vullo, CT. Supuran, J-Y. Winum, Bioorg. Med. Chem., 2014, 22, 6353-6359.
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2013

Antimalarial activity of compounds comprising a primary benzene sulfonamide fragment. K. T. Andrews, G. M. Fisher, S. D.M. Sumanadasa, T. Skinner-Adams, J. Moeker, M. Lopez and S.-A. Poulsen, Bioorganic and Medicinal Chemistry Letters, 2013, 23 (22), 6114-6117. link


Synthesis of acylated glycoconjugates as templates to investigate in vitro biopharmaceutical properties. C. J. Carroux, J. Moeker, J. Motte, M. Lopez, L. F. Bornaghi, K. Katneni, E. Ryan, J. Morizzi, D. M. Shackleford, S. A. Charman and S.-A. Poulsen, Bioorganic and Medicinal Chemistry Letters, 2013, 23 (2), 455-459. link


Engineering of biomolecules for sensing and imaging applications, S. Ulrich, P. Dumy, D. Boturyn, O. Renaudet, J. Drug Del. Sci. Tech., 2013, 23 (1), 5-15. link


Synthesis of rapamycin glycoconjugates via a CuAAC-based approach. L. Moni, A. Marra, J. S. Skotnicki, F. E. Koehn, M. Abou-Gharbia, A. Dondoni, Tetrahedron Lett., 2013, (54), 6999-7003. link


Tetravalent glycocyclopeptide with nanomolar affinity to wheat germ agglutinin. M. Fiore, N. Berthet, A. Marra, E. Gillon, P. Dumy, A. Dondoni, A. Imberty, O. Renaudet, Org. Biomol. Chem., 2013, (11), 7113-7122. link


Efficiency of the free-radical hydrophosphonylation of alkenes : The photoinduced reaction of dimethyl H-phosphonate with enopyranoses as an exemplary case. A. Dondoni, S. Staderini, A. Marra, Eur. J. Org. Chem., 2013, 5370-5375. link


Multivalent presentation of a hydrolytically stable GM3 lactone mimetic as modulator of melanoma cells motility and adhesion. B. Richichi, G. Comito, L. Cerofolini, G. Gabrielli, A. Marra, L. Moni, A. Pace, L. Pasquato, P. Chiarugi, A. Dondoni, L. Toma, C. Nativi, Bioorg. Med. Chem., 2013, (21), 2756-2763. link


Thiyl glycosylation of propargylated octasilsesquioxane : Synthesis and lectin binding properties of densely glycosylated clusters on a cubic platform. A. Marra, S. Staderini, N. Berthet, P. Dumy, O. Renaudet, A. Dondoni, Eur. J. Org. Chem., 2013, 1144-1149. link


Metronidazole-coumarin conjugates and 3-cyano-7-hydroxy-coumarin act as isoform-selective carbonic anhydrase inhibitors. A. Bonneau, A. Maresca, J-Y. Winum, C.T. Supuran, J. Enzyme Inhib. Med. Chem., 2013,28, 397-401. Link


Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche. F.E. Lock, P. Mcdonald, Y. Lou, C. Ostlund, S. Aparicio, J-Y. Winum, C.T. Supuran, S. Dedhar, Oncogene, 2013, 32, 5210–5219. Link


Glycosidic carbonic anhydrase IX inhibitors : a sweet approach against cancer. J-Y. Winum, P. Colinas, C.T. Supuran, Bioorg. Med. Chem., 2013, 21, 1419-1426. Link


Novel antibody to a carbonic anhydrase (WO2011138279). C. Capasso, J-Y. Winum, Expert Opin. Ther. Pat., 2013, 23, 757-760. Link


A spectrophotometric and thermodynamic study of the charge-transfer complexes of N-aryl-N’-isopropyloxycarbonylsulfamides with DDQ and TCNE. M. Belfaragui, A. Seridi, J-Y. Winum, M. Abdaoui, M. Kadri, Spectrochim. Acta A Mol. Biomol. Spectrosc., 2013, 108, 55-61. Link


Thiol-ene click chemistry for the synthesis of highly effective glycosyl sulfonamide carbonic anhydrase inhibitors. MC. Saada, J. Ombouma, J-L. Montero, CT. Supuran, J-Y. Winum, Chem. Commun., 2013, 49, 5699-701. Link


Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation : A new concept of dual targeting drugs. L. Dubois, SG. Peeters, SJ. Van Kuijk, A. Yaromina, NG. Lieuwes, R. Saraya, R. Biemans, M. Rami, NK. Parvathaneni, D. Vullo, M. Vooijs, CT. Supuran, J-Y. Winum, P. Lambin, Radiother. Oncol., 2013, 108, 523-528. Link


Hypoxia-targeting Carbonic Anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamide /sulfamide/ sulfamate. M. Rami, L. Dubois, NK. Parvathaneni, V. Alterio, S. Van Kujik, S. Monti, P. Lambin, G. De Simone, CT. Supuran, J-Y. Winum, J. Med. Chem., 2013, 56, 8512-8520. Link


2012

Zinc metalloenzymes as new targets against the bacterial pathogen Brucella. M. Lopez, S. Köhler, J.-Y. Winum, Journal of Inorganic Biochemistry, 2012, 111, 138-145. link


Design and synthesis of thiourea inhibitors targeting transmembrane carbonic anhydrases. J. Möker, K. Teruya, S. Rossit, B. L. Wilkinson, M. Lopez, L. F. Bornaghi, A. Innocenti, C. T. Supuran, S.-A. Poulsen, Bioorganic and Medicinal Chemistry, 2012, 20 (7), 2392-2404. link


Chemo-enzymatic Synthesis of Xylogluco-Oligosaccharides and their Interactions with Cellulose. M. Lopez, S. Fort, H. Bizot, A. Buléon, H. Driguez, Carbohydrate polymers, 2012, 88, 185-193. link


Conformational constraints : Nature does it best with sialyl LewisX. A. Titz, A. Marra, B. Cutting, M. Smieško, G. Papandreou, A. Dondoni, B. Ernst, Eur. J. Org. Chem., 2012, 5534-5539. link


Glycoside and peptide clustering around the octasilsesquioxane scaffold via photoinduced free-radical thiol-ene coupling. The observation of a striking glycoside cluster effect. M. Lo Conte, S. Staderini, A. Chambery, N. Berthet, P. Dumy, O. Renaudet, A. Marra, A. Dondoni, Org. Biomol. Chem., 2012, (10), 3269-3277. link


Discussion Addendum for : Diastereoselective homologation of D-(R)-glyceraldehyde acetonide using 2-(trimethylsilyl)thiazole : 2-O-benzyl-3,4-isopropylidene-D-erythrose. A. Dondoni, A. Marra, Org. Synth., 2012, (89), 323-333. link


Free-radical hydrothiolation of glycals : a thiol-ene-based synthesis of S-disaccharides. S. Staderini, A. Chambery, A. Marra, A. Dondoni, Tetrahedron Lett., 2012, (53), 702-704. link


Recent applications of thiol–ene coupling as a click process for glycoconjugation. A. Dondoni, A. Marra, Chem. Soc. Rev., 2012, (41), 573-586. link


Biodistribution and Pharmacokinetic Studies of a Porphyrin Dimer Photosensitizer (Oxdime) by Fluorescence Imaging and Spectroscopy in Mice Bearing Xenograft Tumors, M. Khurana, S. Ulrich, A. Kim, Y. Moriyama, G. Netchev, M. K. Akens, H. L. Anderson, B. C. Wilson, Photochem. Photobiol., 2012, 88, 1531-1538. link


Dissecting Chemical Interactions Governing RNA Polymerase II Transcriptional Fidelity, M. W. Kellinger, S. Ulrich, J. Chong, E. T. Kool, D. Wang, J. Am. Chem. Soc., 2012, 134, 8231-8240. link


Polypharmacology of sulfonamides : pazopanib, a multitargeted receptor tyrosine kinase inhibitor in clinical use, potently inhibits several mammalian carbonic anhydrases. J-Y. Winum, A. Maresca, F. Carta, A. Scozzafava, C.T. Supuran, Chem. Commun., 2012, 48 (66), 8177-8179. link


Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics. P. Mcdonald, J-Y. Winum, C.T. Supuran, S. Dedhar, Oncotarget, 2012, 3, 84-97. Link=422&pubmed-linkout=1]


Inhibition of the beta-carbonic anhydrases from the bacterial pathogen Brucella suis with inorganic anions. A. Maresca, A. Scozzafava, S. Kohler, J-Y. Winum, C.T. Supuran, J. Inorg. Biochem., 2012, 110, 36-39. Link


Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. G. Balboni, C. Congiu, V. Onnis, A. Maresca, A. Scozzafava, J-Y. Winum, C.T. Supuran, Bioorg. Med. Chem. Lett., 2012, 22, 3063-3066. Link


Anti-metastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts. R.G. Gieling, M. Babur, L. Mamnani, N. Burrows, B.A. Telfer, F. Carta, J-Y. Winum, A. Scozzafava, C.T. Supuran, K.J. Williams, J. Med. Chem., 2012, 55, 5591-5600. Link


Ureido-Substituted Sulfamates With Potent Carbonic Anhydrase Ix Inhibitory And Antitumor Activities. J-Y. Winum, F. Carta, C. Ward, P. Mullen, D. Harrison, S. Langdon, A. Cecchi, A. Scozzafava, I. Kunkler, C.T. Supuran, Bioorg. Med. Chem. Lett., 2012, 22, 4681-4685. Link


Development of Potent Carbonic Anhydrase Inhibitors Incorporating Both Sulfonamide And Sulfamide Groups. K. D’ambroso, F-Z. Smaine, F. Carta, G. De Simone, J-Y. Winum, C.T. Supuran, J. Med. Chem., 2012, 55, 6776-6783. Link