Recent study realised by the Green Chemistry and Enabling Technologies team of IBMM is on the cover of the last issue of the Green Chemistry journal. In this communication entitled « Environmentally benign peptide synthesis using liquid-assisted ball-milling : application to the synthesis of Leu-enkephalin » (Green Chem., 2013, 15, 1116), Julien Bonnamour, Thomas-Xavier Métro, Jean Martinez and Frédéric Lamaty showed that utilisation of the ball-milling technique allowed efficient peptide synthesis while avoiding usually employed toxic reagents and solvents. This innovative approach has been successfully applied to the total synthesis of the pentapeptide Leu-enkephalin.
Link for the cover : http://pubs.rsc.org/en/content/articlepdf/2013/gc/c3gc90014b
Voir en ligne : Link for the publication