Lost in condensation: poly, cyclo, and ultraphosphates
Séminaire Chimie ED459
Prof. Henning
Le Jeudi 15 Juin 2023 à 14h
CNRS, Amphithéâtre Balard (bâtiment Balard RdC, 1919 route de Mende)
Date de début : 2023-06-15 14:00:00
Date de fin : 2023-06-15 15:30:00
Lieu : CNRS amphi Balard
Intervenant : Prof. Henning
University of Freiburg, Germany
Much like linear, branched, and cyclic alkanes, condensed phosphates exist as linear, branched, and cyclic structures. Inasmuch as alkanes are the cornerstone of organic chemistry, generating an inexplorably large chemical space, a comparable richness in structures can be expected for condensed phosphates, as also for them the concepts of isomerism apply. There is a rich but underexplored chemistry of the family of condensed phosphates per se, which is further diversified by their conjugation to important biomolecules and metabolites. For example, proteins may be polyphosphorylated on lysins, a very recent addition to posttranslational modifications. In this presentation, I will describe our motivations and our approaches to construct, modify, and synthetically apply different representatives of the condensed phosphates. I will also describe the generation of hybrids composed of cyclic and linear structures of different oxidation states and how one can develop them into reagents of great utility.
Contact local IBMM : Dr. Béatrice
