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Solvent-free Peptide Synthesis

par florent_r0s1 - publié le , mis à jour le

Solvent-free Peptide Synthesis

Chemists from the Department of Aminoacids, Peptides and Proteins of the IBMM have developed the first solvent-free method for making a peptide bond by employing a ball-mill grinder. In the absence of solvent, the ball-mill was used to couple urethane protected aminoacid N-carboxyanhydride and an aminoester to produce several dipeptides and a tripeptide. Sweetener aspartame was synthesized using this method. This represents a greener approach to the preparation of peptides, particularly as these compounds become more popular as pharmaceuticals.
This work was highlighted in Chemical & Engineering News (Nov.9, 2009, 87(45), p.41).

Link to the original article : Valérie Declerck, Pierrick Nun, Jean Martinez, Frédéric Lamaty
« Solvent-free Synthesis of Peptides »
Angew. Chem. Int. Ed. 2009, 48, 9318-9321.
DOI : 10.1002/anie.200903510

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  • Aspartame