Biography
Céline Crauste obtained her PhD in organic chemistry at the IBMM in the group of Pr. C. Perigaud in 2008. During her PhD, she worked under the supervision of Dr. S. Peyrottes, on the supported synthesis of nucleotides, based on soluble support, and also on the development of a new LC/MS/MS methodology to access intracellular concentrations of triphosphate derivatives in biological samples, under the supervision of Dr. I. Lefebvre. She did a first post-doctoral work at the Katholieke Universiteit of Leuven, in Belgium in 2009 with Pr. Piet Herdewijn in the field of total asymmetrical synthesis of lipo-peptides, used as new antibiotics. In 2010-2011, during her second post-doctoral fellow in the laboratory of Pr. B. Deprez (pharmaceutical university of Lille, France), she developed a new surface plasmon resonance (SPR) assay to study ligand/protein interactions in the field of new antituberculosis treatment with Pr. Nicolas Willand and Dr. Alain Baulard. Since 2012, and after a first ATER position in the team “Synthesis of Bioactive Lipids” at the IBMM, she was promoted assistant professor in pharmacognosy at the University of Montpellier. Her research area focuses on medicinal chemistry, includes the synthesis and the evaluation of lipophenols derivatives to fight oxidative and carbonyl stress mechanism (neurodegenerative diseases), the discovery of natural lipophenols in vegetal sources and the study of their metabolisation, and the development of lipid-oxadiazolone, inhibitors of lipolytic enzymes in mycobacteria.