Enamides, ynamides, N-allenamides, versatile building blocks in organic synthesis
Séminaire Chimie ED459
Dr. Laurence
Le Jeudi 15 Décembre 2022 à 10h30
CNRS, Amphithéâtre Balard (bâtiment Balard RdC, 1919 route de Mende)
Date de début : 2022-12-15 10:30:00
Date de fin : 2022-12-15 11:30:00
Lieu : CNRS amphi Balard
Intervenant : Dr. Laurence
Équipe SOPhy Synthèse Organique et Phytochimie, Institut de Chimie de Strasbourg, UMR 7177 CNRS, Université de Strasbourg
Ynamides, enamides and N-allenamides are privileged building blocks due to their interesting balance between stability and reactivity. Domino reactions assisted by tertiary enamide were developed to access polycyclic fused ring systems. Difluorinated amidofurans and N-allenamides were obtained through copper-catalyzed addition of diazo-compounds on terminal ynamides. Trifluoromethylated N-allenamides allowed the synthesis of gem-difluorinated ene-ynamides. These highly reactive species, owing to their dual functional groups, offer a unique entry to difluorinated dienes and to stereodefined mono-fluoro-substituted dienes.
Contact local ICGM : Dr. Florian
