Photo de ULRICH Sébastien
ULRICH Sébastien      
Fonction : Chargé de recherche - HDR
Thème de Recherche: Synthèse Glycosidique et Reconnaissance Moléculaire
Bureau: P35, Etg: 4, Bât: REcherche - Site : ENSCM rue école normale

  • Médaille de bronze CNRS
Activités de Recherche:     
Sébastien Ulrich carried out his PhD under the guidance of Pr. Jean-Marie Lehn at ISIS, Strasbourg, France, developing molecular switches for controlling dynamic combinatorial libraries. He subsequently joined the groups of Pr. Harry L. Anderson (Oxford University, UK) as an EPSRC fellow and of Pr. Eric T. Kool (Stanford University, CA, USA) as a Fulbright fellow. In 2011 he was awarded an ANR starting grant and joined the group of Pr. Pascal Dumy, first in Grenoble, then at IBMM in Montpellier, France where he was promoted to a permanent CNRS research position in 2012. He was named Junior Distinguished member of the French Chemical Society in 2014 and was awarded the bronze medal by the CNRS in 2017.
His current research interests lie at the interface of supramolecular chemistry and bioorganic chemistry, and focus in particular on the design and study of dynamic and adaptive multivalent self-assembled systems for biological applications such as nucleic acids recognition and delivery.

Mihail BARBOIU, IEM-Université de Montpellier, France
Nadir BETTACHE/Magali GARY-BOBO, IBMM-Université de Montpellier, France
Sonia CANTEL, IBMM-Université de Montpellier, France
Sébastien CLEMENT/Sébastien RICHETER, ICGM-Université de Montpellier, Montpellier, France
Virginie GERVAIS, IPBS-Plateforme Intégrée de Criblage de Toulouse (PICT), Toulouse, France
Artur STEFANKIEWICZ, Adam Mickiewicz University, Poznañ, Poland
Mathieu SURIN, Université de Mons, Belgium

LIST OF PUBLICATIONS (updated January 2021):


43) Synthesis, self-assembly and nucleic acid recognition of an acylhydrazone-conjugated cationic tetraphenylethene ligand, M. Coste, C. Kotras, Y. Bessin, V. Gervais, D. Dellemme, M. Leclercq, M. Fossépré, S. Richeter, S. Clément, M. Surin, S. Ulrich, Eur. J. Org. Chem., 2021, DOI 10.1002/ejoc.202001420. link
42) Cell‐selective siRNA delivery using glycosylated dynamic covalent polymers self‐assembled in situ by RNA‐templating, N. Laroui, M. Coste, D. Su, L. Ali, Y. Bessin, M. Barboiu, M. Gary-Bobo, N. Bettache, S. Ulrich, Angew. Chem. Int. Ed., 2021, DOI 10.1002/anie.202014066. link


41) Cationic Dynamic Covalent Polymers for Gene Transfection, D. Su, M. Coste, A. Diaconu, M. Barboiu, S. Ulrich, J. Mater. Chem. B, 2020, 8, 9385-9403. link
40) From Interaction to Function in DNA‐Templated Supramolecular Self‐Assemblies, M. Surin, S. Ulrich, ChemistryOpen, 2020, 9, 480-498. link
39) Dynamic covalent polymers for biomedical applications, Y. Zhang, Y. Qi, S. Ulrich, M. Barboiu, O. Ramström, Materials Chemistry Frontiers, 2020, 4, 489-506. link


38) Combination of photodynamic therapy and gene silencing achieved through the hierarchical self-assembly of porphyrin-siRNA complexes. N. Laroui, M. Coste, L. Lichon, Y. Bessin, M. Gary-Bobo, G. Pratviel, C. Bonduelle, N. Bettache, S. Ulrich, Int. J. Pharm., 2019, 569, 118585. link
37) Tuning the Solubility of Self-Assembled Fluorescent Aromatic Cages Using Functionalized Amino Acid Building Blocks. M. Konopka, P. Cecot, S. Ulrich, A. R. Stefankiewicz, Front. Chem., 2019, 7, Article 503. link
36) A cationic tetraphenylethene as a light-up supramolecular probe for DNA G-quadruplexes. C. Kotras, M. Fossepre, M. Roger, V. Gervais, S. Richeter, P. Gerbier, S. Ulrich, M. Surin, S. Clément, Front. Chem., 2019, 7, Article 493. link
35) Growing Prospects of Dynamic Covalent Chemistry in Delivery Applications. S. Ulrich, Acc. Chem. Res., 2019, 52, 2, 510-519. link


34) Biomolecular Dynamic Covalent Polymers for DNA complexation and siRNA delivery. C. Bouillon, Y. Bessin, F. Poncet, M. Gary-Bobo, P. Dumy, M. Barboiu, N. Bettache, S. Ulrich, J. Mater. Chem. B., 2018, 7239-7246. link
33) Multivalent metallosupramolecular assemblies as effective DNA binding agents. W. Drożdż, A. Walczak, Y. Bessin, V. Gervais, X.‐Y. Cao, J.‐M. Lehn, S. Ulrich, A. R. Stefankiewicz, Chem. Eur. J., 2018, 24, 10802-10811. link
32) Auto-assemblages dynamiques pour la reconnaissance et la vectorisation d’acides nucleiques. S. Ulrich, L’Actualité Chimique, 2018, 430-431, 61-67. link
31) Self-assembly and chiroptical properties in supramolecular complexes of adenosine phosphates and guanidinium-bispyrene. M. Trévisan, M. Fossépré, D. Paolantoni, J. Rubio‐Magnieto, P. Dumy, S. Ulrich, M. Surin, Chirality, 2018, 30 (6), 719-729. link
30) Switching multivalent DNA complexation using metallo-controlled cationic supramolecular self-assemblies. W. Drożdż, Y. Bessin, V. Gervais, X.-Y. Cao, J.-M. Lehn, A. R. Stefankiewicz, S. Ulrich, Chem. Eur. J., 2018, 24 (7), 1518-1521. link
29) Photomodulation of DNA-templated supramolecular assemblies. J. Rubio-Magnieto, T.-A. Phan, M. Fossépré, V. Matot, J. Knoops, T. Jarrosson, P. Dumy, F. Serein-Spirau, C. Niebel, S. Ulrich, M. Surin, Chem. Eur. J., 2018, 24 (3), 706-714. link


28) Generation of Multicomponent Molecular Cages using Simultaneous Dynamic Covalent Reactions. W. Drożdż, C. Bouillon, C. Kotras, S. Richeter, M. Barboiu, S. Clément, A. R. Stefankiewicz, S. Ulrich, Chem. Eur. J., 2017, 23, 18010-18018. link
27) Polyhedral oligomeric silsesquioxane (POSS) bearing glyoxylic aldehyde as clickable platform towards multivalent conjugates. N. Kanfar, A. Mehdi, P. Dumy, S. Ulrich, J.-Y. Winum, Chem. Eur. J., 2017, 23, 17867-17869. link
26) One-Pot Self-Assembly of Peptide-Based Cage-Type Nanostructures using Orthogonal Ligations. E. Bartolami, J. Knoops, Y. Bessin, M. Fossépré, J. Chamieh, P. Dumy, M. Surin, S. Ulrich, Chem. Eur. J., 2017, 23, 14323-14331. link
25) Effective Access to Multivalent Inhibitors of Carbonic Anhydrases Promoted by Peptide Bioconjugation. N. Kanfar, M. Tanc, P. Dumy, C. T. Supuran, S. Ulrich, J.-Y. Winum, Chem. Eur. J., 2017, 23 (28), 6788-6794. link
24) Auto-assemblage dynamique de clusters cationiques pour la complexation et la vectorisation d’acides nucléiques. E. Bartolami, S. Ulrich, P. Dumy, L’Actualité Chimique, 2017, 417. link


23) Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution. C. S. Hwang, L. Xu, W. Wang, S. Ulrich, L. Zhang, J. Chong, J. H. Shin, X. Huang, E. T. Kool, C. E. McKenna, D. Wang, Nucl. Acids Res., 2016, 44 (8), 3820-3828. link
22) Bioactive clusters promoting cell penetration and nucleic acids complexation for drug and gene delivery applications: from designed to self-assembled and responsive systems. E. Bartolami, C. Bouillon, P. Dumy, S. Ulrich, Chem. Commun., 2016, 52, 4257-4273. link
21) A metal-free synthetic approach to peptide-based iminosugar clusters as novel multivalent glycosidase inhibitors. R. Zelli, E. Bartolami, J.-F. Longevial, Y. Bessin, P. Dumy, A. Marra, S. Ulrich, RSC Adv., 2016, 6, 2210-2216. link


20) Emerging trends in enzyme inhibition by multivalent nanoconstructs. N. Kanfar, E. Bartolami, R. Zelli, A. Marra, J.-Y. Winum, S. Ulrich, P. Dumy, Org. Biomol. Chem., 2015, 13, 9894-9906. link
19) Multivalent DNA recognition by self-assembled clusters: deciphering structural effects by fragments screening and evaluation as siRNA vectors. E. Bartolami, Y. Bessin, N. Bettache, M. Gary-Bobo, M. Garcia, P. Dumy, S. Ulrich, Org. Biomol. Chem., 2015, 13, 9427-9438 (themed collection: Multivalent Biomolecular Recognition). link
18) Dynamic expression of DNA complexation with self-assembled biomolecular clusters. E. Bartolami, Y. Bessin, V. Gervais, P. Dumy, S. Ulrich, Angew. Chem. Int. Ed., 2015, 54 (35), 10183-10187. link
17) Fluorescent silica nanoparticles with multivalent inhibitory effects towards carbonic anhydrases. N. Touisni, N. Kanfar, S. Ulrich, P. Dumy, C.T. Supuran, A. Mehdi, J.-Y. Winum, Chem. Eur. J., 2015, 21 (29), 10306-10309. link
16) Synthesis of a-PNA containing a functionalized triazine as nucleobase analogue. E. Bartolami, A. Gilles, P. Dumy, S. Ulrich, Tetrahedron Lett., 2015, 56 (18), 2319-2323. link
15) A Dynamic Combinatorial Approach for Identifying Side Groups that Stabilize DNA-Templated Supramolecular Self-Assemblies. D. Paolantoni, S. Cantel, P. Dumy, S. Ulrich, Int. J. Mol. Sci., 2015, 16, 3609-3625 (special issue "Supramolecular interactions"). link


14) Probing the importance of π-stacking interactions in DNA-templated self-assembly of bisfunctionalized guanidinium compounds. D. Paolantoni, J. Rubio-Magnieto, S. Cantel, J. Martinez, P. Dumy, M. Surin, S. Ulrich, Chem. Commun., 2014, 50, 14257-14260. link
13) Degradable Hybrid Materials Based on Cationic Acylhydrazone Dynamic Covalent Polymers Promote DNA Complexation through Multivalent Interactions. C. Bouillon, D. Paolantoni, J. C. Rote, Y. Bessin, L. W. Peterson, P. Dumy, S. Ulrich, Chem. Eur. J., 2014, 20 (45), 14705-14714. link
12) Probing Secondary Interactions in Biomolecular Recognition by Dynamic Combinatorial Chemistry. S. Ulrich, P. Dumy, Chem. Commun., 2014, 50 (44), 5810-5825 (“Systems chemistry: a web themed issue”). link
11) Theoretical and Structural Analysis of Long C–C Bonds in the Adducts of Polycyanoethylene and Anthracene Derivatives and their Connection to the Reversibility of Diels–Alder Reactions. A. K. H. Hirsch, P. Reutenauer, M. Le Moignan, S. Ulrich, P. J. Boul, J. M. Harrowfield, P. D. Jarowski, J.-M. Lehn, Chem. Eur. J., 2014, 20 (4), 1073-1080. link
10) Oxime Ligation: a Chemoselective Click-Type Reaction for Accessing Multifunctional Biomolecular Constructs. S. Ulrich, D. Boturyn, A. Marra, O. Renaudet, P. Dumy, Chem. Eur. J., 2014, 20 (1), 34-41. link


9) Engineering of biomolecules for sensing and imaging applications. S. Ulrich, P. Dumy, D. Boturyn, O. Renaudet, J. Drug Del. Sci. Tech., 2013, 23 (1), 5-15. link


8) Biodistribution and Pharmacokinetic Studies of a Porphyrin Dimer Photosensitizer (Oxdime) by Fluorescence Imaging and Spectroscopy in Mice Bearing Xenograft Tumors, M. Khurana, S. Ulrich, A. Kim, Y. Moriyama, G. Netchev, M. K. Akens, H. L. Anderson, B. C. Wilson, Photochem. Photobiol., 2012, 88, 1531-1538. link
7) Dissecting Chemical Interactions Governing RNA Polymerase II Transcriptional Fidelity, M. W. Kellinger, S. Ulrich, J. Chong, E. T. Kool, D. Wang, J. Am. Chem. Soc., 2012, 134, 8231-8240. link


6) Importance of Steric Effects on the Efficiency and Fidelity of Transcription by T7 RNA Polymerase, S. Ulrich, E. T. Kool, Biochemistry, 2011, 50 (47), 10343-10349. link


5) Metallo-controlled Dynamic Molecular Tweezers: Design, Synthesis, and Self-assembly by Metal-ion Coordination, S. Ulrich, A. Petitjean, J.-M. Lehn, Eur. J. Inorg. Chem., 2010, 13, 1913-1928. link


4) Adaptation and Optical Signal Generation in a Constitutional Dynamic Network, S. Ulrich, J.-M. Lehn, Chem. Eur. J., 2009, 15, 5640-5645. link
3) Adaptation to Shape Switching by Component Selection in a Constitutional Dynamic System, S. Ulrich, J.-M. Lehn, J. Am. Chem. Soc., 2009, 131, 5546-5559. link
2) Reversible Constitutional Switching between Macrocycles and Polymers Induced by Shape Change in a Dynamic Covalent System, S. Ulrich, E. Buhler, J.-M. Lehn, New. J. Chem., 2009, 33, 271-292. link


1) Reversible Switching between Macrocyclic and Polymeric States by Morphological Control in a Constitutional Dynamic System, S. Ulrich, J.-M. Lehn, Angew. Chem. Int. Ed., 2008, 47, 2240-2243. link
Domaines de Recherche:
  • Chimie/Chimie organique
  • Chimie
Productions scientifiques :
+ Photomodulation of DNA-Templated Supramolecular Assemblies doi link

Auteur(s): Rubio-Magnieto Jenifer, Phan Tuan-Anh, Fossépré Mathieu, Matot Valérie, Knoops Jeremie, Jarrosson Thibaut, Dumy P., Serein-Spirau Françoise, Niebel Claude, Ulrich S.(Corresp.), Surin Mathieu

(Article) Publié: Chemistry - A European Journal, vol. 24 p.706-714 (2018)

+ Generation of Multicomponent Molecular Cages using Simultaneous Dynamic Covalent Reactions doi link

Auteur(s): Drożdż Wojciech, Bouillon C., Clément Clément, Richeter Sébastien, Barboiu Mihail, Clément Sébastien, Stefankiewicz Artur R., Ulrich S.

(Article) Publié: Chemistry - A European Journal, vol. 23 p.18010 - 18018 (2017)

+ Oxime Ligation: A Chemoselective Click-Type Reaction for Accessing Multifunctional Biomolecular Constructs doi link

Auteur(s): Ulrich S., Boturyn Didier, Marra A., Renaudet Olivier, Dumy P.

(Article) Publié: Chemistry - A European Journal, vol. 20 p.34 - 41 (2014)