Distinctions
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Research Activities: |
Sébastien Ulrich carried out his PhD in molecular and supramolecular chemistry under the guidance of Pr. Jean-Marie
Lehn (ISIS/Université de Strasbourg, France), developing molecular switches for controlling dynamic combinatorial libraries. He subsequently joined the groups of Pr. Harry L. Anderson (Oxford University, UK) as an EPSRC fellow and of Pr. Eric T. Kool (Stanford University, CA, USA) as a Fulbright fellow. In 2011 he was awarded an ANR starting grant and joined the group of Pr. Pascal Dumy (DCM, Grenoble, France). In 2012, he was recruited as Research Associate by the CNRS (IBMM, Montpellier, France). In 2014, he was named Junior Distinguished member of the French Chemical Society and, in 2017, was rewarded the CNRS bronze medal. In 2023, he was promoted Directeur de Recherche by the CNRS. RESEARCH TOPIC: SUPRAMOLECULAR BIOORGANIC CHEMISTRY -Axis 1 : Dynamic and adaptive systems for the drug & gene delivery. -Axis 2 : Biomolecular Self-Assemblies: self-organization of small molecules on nucleic acid templates, hierarchical self-assembly of cages/polymers/networks. CURRENT ACTIVE COLLABORATIONS: Mihail BARBOIU, IEM-Université de Montpellier, France Nadir BETTACHE/Magali GARY-BOBO, IBMM-Université de Montpellier, France Prisca BOISGUERIN, PhyMedExp, Montpellier, France Fabien COUGNON, University of Jyväskylä, Finlande Yann FERRAND, CBMN, Bordeaux, France Virginie GERVAIS, I2BC CNRS/CEA/Université Paris-Saclay, France Loic JIERRY/Pierre SCHAAF, ICS, Strasbourg, France Laurent KREMER, IRIM, Montpellier, France Jérôme LACOUR, Université de Genève, Suisse Frédéric LAMATY, IBMM, Montpellier, France Jeanne LEBLOND CHAIN, ARNA, INSERM, Université de Bordeaux, France Zbigniew PIANOWSKI, KIT, Karlsruhe, Allemagne Sébastien RICHETER/Sébastien CLEMENT, ICGM-Université de Montpellier, Montpellier, France Sandrine SAGAN/Emmanuelle SACHON/Fabienne BURLINA/Astrid WALRANT/Françoise ILLIEN, LBM, Sorbonne Université, Paris, France Artur STEFANKIEWICZ, Adam Mickiewicz University, Poznañ, Poland Mathieu SURIN, Université de Mons, Belgium Yann TROLEZ, ICSR, Rennes, France Ghislaine VANTOMME, Eindhoven University of Technology, Pays-Bas Max VON DELIUS, University of Ulm, Germany LIST OF PUBLICATIONS (updated January 2024): 2024 57) Self-assembled porphyrin–peptide cages for photodynamic therapy, C. Ghosh, L. M. A. Ali, Y. Bessin, S. Clément, S. Richeter, N. Bettache, S. Ulrich, Org. Biomol. Chem., 2024, DOI 10.1039/D3OB01887C. link 56) Dynamic covalent synthesis, F. B. L. Cougnon, A. R. Stefankiewicz, S. Ulrich, Chem. Sci., 2024, 15, 879-895. link 2023 55) If order can be, order will be - Retour sur les 2èmes Journées de Chimie Supramoléculaire, D. Bourgeois, S. Ulrich, L’Actualité Chimique, 2023, 487, 4-5. link 54) Bis-Alkylureido Imidazole Artificial Water Channels, D.-D. Su, S. Ulrich, M. Barboiu, Angew. Chem. Int. Ed., 2023, 62, 35, e202306265. link 53) Nucleic-Acid-Templated Synthesis of Smart Polymer Vectors for Gene Delivery, J. García Coll, S. Ulrich, ChemBioChem, 2023, 24, 19, e202300333. link 52) A triazolium-anchored self-immolative linker enables self-assembly-driven siRNA binding and esterase-induced release, S. Hollstein, L. M. A. Ali, M. Coste, J. Vogel, N. Bettache, S. Ulrich, M. von Delius, Chem. Eur. J., 2023, 29, 8, e202203311. link 51) Complexation Preferences of Dynamic Constitutional Frameworks as Adaptive Gene Vectors, D. Su, V. Gervais, S. Ulrich, M. Barboiu, Chem. Eur. J., 2023, 29, 8, e202203062. link 50) Structure-Activity Relationships in Nucleic-Acid-Templated Vectors Based on Peptidic Dynamic Covalent Polymers, D. Su, L. M. A. Ali, M. Coste, N. Laroui, Y. Bessin, M. Barboiu, N. Bettache, S. Ulrich, Chem. Eur. J., 2023, 29, 7, e202202921. link 2022 49) Fluorescent Dynamic Covalent Polymers for DNA Complexation and Templated Assembly, C. Kotras, M. Leclercq, M. Roger, C. Bouillon, A. Recupido, A. Lebrun, Y. Bessin, P. Gerbier, S. Richeter, S. Ulrich, S. Clément, M. Surin, Molecules, 2022, 27 (19), 6648. link 48) Squalene–polyethyleneimine–dynamic constitutional frameworks enhancing the enzymatic activity of carbonic anhydrase, D. Su, K. Aissou, Y. Zhang, V. Gervais, S. Ulrich, M. Barboiu, Catal. Sci. Technol., 2022, 12, 3094-3101. link 47) Quadruple Functionalization of a Tetraphenylethylene Aromatic Scaffold with Ynamides or Tetracyanobutadienes: Synthesis and Optical Properties, C. Philippe, M. Coste, Y. Bretonnière, L. Lemiègre, S. Ulrich, Y. Trolez, Eur. J. Org. Chem., 2022, e202200049. link 46) Hierarchical Self-Assembly of Aromatic Peptide Conjugates into Supramolecular Polymers: it takes two to tango, M. Coste, E. Suárez-Picado, S. Ulrich, Chem. Sci., 2022, 13, 909-933. link 45) Hierarchical self-assembly and multi-dynamic responsiveness of fluorescent dynamic covalent networks forming organogels, E. Suárez-Picado, M. Coste, J.-Y. Runser, M. Fossépré, A. Carvalho, M. Surin, L. Jierry, S. Ulrich, Biomacromolecules, 2022, 23, 1, 431-442. link 2021 44) Constitutional Dynamic Inhibition/Activation of Carbonic Anhydrases, D. Su, Y. Zhang, S. Ulrich, M. Barboiu, ChemPlusChem, 2021, 86, 11, 1500-1510. link 43) Synthesis, self-assembly and nucleic acid recognition of an acylhydrazone-conjugated cationic tetraphenylethene ligand, M. Coste, C. Kotras, Y. Bessin, V. Gervais, D. Dellemme, M. Leclercq, M. Fossépré, S. Richeter, S. Clément, M. Surin, S. Ulrich, Eur. J. Org. Chem., 2021, 7, 1123-1135. link 42) Cell‐selective siRNA delivery using glycosylated dynamic covalent polymers self‐assembled in situ by RNA‐templating, N. Laroui, M. Coste, D. Su, L. Ali, Y. Bessin, M. Barboiu, M. Gary-Bobo, N. Bettache, S. Ulrich, Angew. Chem. Int. Ed., 2021, 60, 11, 5783-5787. link 2020 41) Cationic Dynamic Covalent Polymers for Gene Transfection, D. Su, M. Coste, A. Diaconu, M. Barboiu, S. Ulrich, J. Mater. Chem. B, 2020, 8, 9385-9403. link 40) From Interaction to Function in DNA‐Templated Supramolecular Self‐Assemblies, M. Surin, S. Ulrich, ChemistryOpen, 2020, 9, 480-498. link 39) Dynamic covalent polymers for biomedical applications, Y. Zhang, Y. Qi, S. Ulrich, M. Barboiu, O. Ramström, Materials Chemistry Frontiers, 2020, 4, 489-506. link 2019 38) Combination of photodynamic therapy and gene silencing achieved through the hierarchical self-assembly of porphyrin-siRNA complexes. N. Laroui, M. Coste, L. Lichon, Y. Bessin, M. Gary-Bobo, G. Pratviel, C. Bonduelle, N. Bettache, S. Ulrich, Int. J. Pharm., 2019, 569, 118585. link 37) Tuning the Solubility of Self-Assembled Fluorescent Aromatic Cages Using Functionalized Amino Acid Building Blocks. M. Konopka, P. Cecot, S. Ulrich, A. R. Stefankiewicz, Front. Chem., 2019, 7, Article 503. link 36) A cationic tetraphenylethene as a light-up supramolecular probe for DNA G-quadruplexes. C. Kotras, M. Fossepre, M. Roger, V. Gervais, S. Richeter, P. Gerbier, S. Ulrich, M. Surin, S. Clément, Front. Chem., 2019, 7, Article 493. link 35) Growing Prospects of Dynamic Covalent Chemistry in Delivery Applications. S. Ulrich, Acc. Chem. Res., 2019, 52, 2, 510-519. link 2018 34) Biomolecular Dynamic Covalent Polymers for DNA complexation and siRNA delivery. C. Bouillon, Y. Bessin, F. Poncet, M. Gary-Bobo, P. Dumy, M. Barboiu, N. Bettache, S. Ulrich, J. Mater. Chem. B., 2018, 7239-7246. link 33) Multivalent metallosupramolecular assemblies as effective DNA binding agents. W. Drożdż, A. Walczak, Y. Bessin, V. Gervais, X.‐Y. Cao, J.‐M. Lehn, S. Ulrich, A. R. Stefankiewicz, Chem. Eur. J., 2018, 24, 10802-10811. link 32) Auto-assemblages dynamiques pour la reconnaissance et la vectorisation d’acides nucleiques. S. Ulrich, L’Actualité Chimique, 2018, 430-431, 61-67. link 31) Self-assembly and chiroptical properties in supramolecular complexes of adenosine phosphates and guanidinium-bispyrene. M. Trévisan, M. Fossépré, D. Paolantoni, J. Rubio‐Magnieto, P. Dumy, S. Ulrich, M. Surin, Chirality, 2018, 30 (6), 719-729. link 30) Switching multivalent DNA complexation using metallo-controlled cationic supramolecular self-assemblies. W. Drożdż, Y. Bessin, V. Gervais, X.-Y. Cao, J.-M. Lehn, A. R. Stefankiewicz, S. Ulrich, Chem. Eur. J., 2018, 24 (7), 1518-1521. link 29) Photomodulation of DNA-templated supramolecular assemblies. J. Rubio-Magnieto, T.-A. Phan, M. Fossépré, V. Matot, J. Knoops, T. Jarrosson, P. Dumy, F. Serein-Spirau, C. Niebel, S. Ulrich, M. Surin, Chem. Eur. J., 2018, 24 (3), 706-714. link 2017 28) Generation of Multicomponent Molecular Cages using Simultaneous Dynamic Covalent Reactions. W. Drożdż, C. Bouillon, C. Kotras, S. Richeter, M. Barboiu, S. Clément, A. R. Stefankiewicz, S. Ulrich, Chem. Eur. J., 2017, 23, 18010-18018. link 27) Polyhedral oligomeric silsesquioxane (POSS) bearing glyoxylic aldehyde as clickable platform towards multivalent conjugates. N. Kanfar, A. Mehdi, P. Dumy, S. Ulrich, J.-Y. Winum, Chem. Eur. J., 2017, 23, 17867-17869. link 26) One-Pot Self-Assembly of Peptide-Based Cage-Type Nanostructures using Orthogonal Ligations. E. Bartolami, J. Knoops, Y. Bessin, M. Fossépré, J. Chamieh, P. Dumy, M. Surin, S. Ulrich, Chem. Eur. J., 2017, 23, 14323-14331. link 25) Effective Access to Multivalent Inhibitors of Carbonic Anhydrases Promoted by Peptide Bioconjugation. N. Kanfar, M. Tanc, P. Dumy, C. T. Supuran, S. Ulrich, J.-Y. Winum, Chem. Eur. J., 2017, 23 (28), 6788-6794. link 24) Auto-assemblage dynamique de clusters cationiques pour la complexation et la vectorisation d’acides nucléiques. E. Bartolami, S. Ulrich, P. Dumy, L’Actualité Chimique, 2017, 417. link 2016 23) Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution. C. S. Hwang, L. Xu, W. Wang, S. Ulrich, L. Zhang, J. Chong, J. H. Shin, X. Huang, E. T. Kool, C. E. McKenna, D. Wang, Nucl. Acids Res., 2016, 44 (8), 3820-3828. link 22) Bioactive clusters promoting cell penetration and nucleic acids complexation for drug and gene delivery applications: from designed to self-assembled and responsive systems. E. Bartolami, C. Bouillon, P. Dumy, S. Ulrich, Chem. Commun., 2016, 52, 4257-4273. link 21) A metal-free synthetic approach to peptide-based iminosugar clusters as novel multivalent glycosidase inhibitors. R. Zelli, E. Bartolami, J.-F. Longevial, Y. Bessin, P. Dumy, A. Marra, S. Ulrich, RSC Adv., 2016, 6, 2210-2216. link 2015 20) Emerging trends in enzyme inhibition by multivalent nanoconstructs. N. Kanfar, E. Bartolami, R. Zelli, A. Marra, J.-Y. Winum, S. Ulrich, P. Dumy, Org. Biomol. Chem., 2015, 13, 9894-9906. link 19) Multivalent DNA recognition by self-assembled clusters: deciphering structural effects by fragments screening and evaluation as siRNA vectors. E. Bartolami, Y. Bessin, N. Bettache, M. Gary-Bobo, M. Garcia, P. Dumy, S. Ulrich, Org. Biomol. Chem., 2015, 13, 9427-9438 (themed collection: Multivalent Biomolecular Recognition). link 18) Dynamic expression of DNA complexation with self-assembled biomolecular clusters. E. Bartolami, Y. Bessin, V. Gervais, P. Dumy, S. Ulrich, Angew. Chem. Int. Ed., 2015, 54 (35), 10183-10187. link 17) Fluorescent silica nanoparticles with multivalent inhibitory effects towards carbonic anhydrases. N. Touisni, N. Kanfar, S. Ulrich, P. Dumy, C.T. Supuran, A. Mehdi, J.-Y. Winum, Chem. Eur. J., 2015, 21 (29), 10306-10309. link 16) Synthesis of a-PNA containing a functionalized triazine as nucleobase analogue. E. Bartolami, A. Gilles, P. Dumy, S. Ulrich, Tetrahedron Lett., 2015, 56 (18), 2319-2323. link 15) A Dynamic Combinatorial Approach for Identifying Side Groups that Stabilize DNA-Templated Supramolecular Self-Assemblies. D. Paolantoni, S. Cantel, P. Dumy, S. Ulrich, Int. J. Mol. Sci., 2015, 16, 3609-3625 (special issue "Supramolecular interactions"). link 2014 14) Probing the importance of π-stacking interactions in DNA-templated self-assembly of bisfunctionalized guanidinium compounds. D. Paolantoni, J. Rubio-Magnieto, S. Cantel, J. Martinez, P. Dumy, M. Surin, S. Ulrich, Chem. Commun., 2014, 50, 14257-14260. link 13) Degradable Hybrid Materials Based on Cationic Acylhydrazone Dynamic Covalent Polymers Promote DNA Complexation through Multivalent Interactions. C. Bouillon, D. Paolantoni, J. C. Rote, Y. Bessin, L. W. Peterson, P. Dumy, S. Ulrich, Chem. Eur. J., 2014, 20 (45), 14705-14714. link 12) Probing Secondary Interactions in Biomolecular Recognition by Dynamic Combinatorial Chemistry. S. Ulrich, P. Dumy, Chem. Commun., 2014, 50 (44), 5810-5825 (“Systems chemistry: a web themed issue”). link 11) Theoretical and Structural Analysis of Long C–C Bonds in the Adducts of Polycyanoethylene and Anthracene Derivatives and their Connection to the Reversibility of Diels–Alder Reactions. A. K. H. Hirsch, P. Reutenauer, M. Le Moignan, S. Ulrich, P. J. Boul, J. M. Harrowfield, P. D. Jarowski, J.-M. Lehn, Chem. Eur. J., 2014, 20 (4), 1073-1080. link 10) Oxime Ligation: a Chemoselective Click-Type Reaction for Accessing Multifunctional Biomolecular Constructs. S. Ulrich, D. Boturyn, A. Marra, O. Renaudet, P. Dumy, Chem. Eur. J., 2014, 20 (1), 34-41. link 2013 9) Engineering of biomolecules for sensing and imaging applications. S. Ulrich, P. Dumy, D. Boturyn, O. Renaudet, J. Drug Del. Sci. Tech., 2013, 23 (1), 5-15. link 2012 8) Biodistribution and Pharmacokinetic Studies of a Porphyrin Dimer Photosensitizer (Oxdime) by Fluorescence Imaging and Spectroscopy in Mice Bearing Xenograft Tumors, M. Khurana, S. Ulrich, A. Kim, Y. Moriyama, G. Netchev, M. K. Akens, H. L. Anderson, B. C. Wilson, Photochem. Photobiol., 2012, 88, 1531-1538. link 7) Dissecting Chemical Interactions Governing RNA Polymerase II Transcriptional Fidelity, M. W. Kellinger, S. Ulrich, J. Chong, E. T. Kool, D. Wang, J. Am. Chem. Soc., 2012, 134, 8231-8240. link 2011 6) Importance of Steric Effects on the Efficiency and Fidelity of Transcription by T7 RNA Polymerase, S. Ulrich, E. T. Kool, Biochemistry, 2011, 50 (47), 10343-10349. link 2010 5) Metallo-controlled Dynamic Molecular Tweezers: Design, Synthesis, and Self-assembly by Metal-ion Coordination, S. Ulrich, A. Petitjean, J.-M. Lehn, Eur. J. Inorg. Chem., 2010, 13, 1913-1928. link 2009 4) Adaptation and Optical Signal Generation in a Constitutional Dynamic Network, S. Ulrich, J.-M. Lehn, Chem. Eur. J., 2009, 15, 5640-5645. link 3) Adaptation to Shape Switching by Component Selection in a Constitutional Dynamic System, S. Ulrich, J.-M. Lehn, J. Am. Chem. Soc., 2009, 131, 5546-5559. link 2) Reversible Constitutional Switching between Macrocycles and Polymers Induced by Shape Change in a Dynamic Covalent System, S. Ulrich, E. Buhler, J.-M. Lehn, New. J. Chem., 2009, 33, 271-292. link 2008 1) Reversible Switching between Macrocyclic and Polymeric States by Morphological Control in a Constitutional Dynamic System, S. Ulrich, J.-M. Lehn, Angew. Chem. Int. Ed., 2008, 47, 2240-2243. link |
Research Topics:
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Photomodulation of DNA-Templated Supramolecular Assemblies Author(s): Rubio-Magnieto Jenifer, Phan Tuan-Anh, Fossépré Mathieu, Matot Valérie, Knoops Jeremie, Jarrosson Thibaut, Dumy P., Serein-Spirau Françoise, Niebel Claude, Ulrich S., Surin Mathieu (Article) Published: Chemistry - A European Journal, vol. 24 p.706-714 (2018) |
Generation of Multicomponent Molecular Cages using Simultaneous Dynamic Covalent Reactions Author(s): Drożdż Wojciech, Bouillon C., Clément Clément, Richeter Sébastien, Barboiu Mihail, Clément Sébastien, Stefankiewicz Artur R., Ulrich S. (Article) Published: Chemistry - A European Journal, vol. 23 p.18010 - 18018 (2017) |
Oxime Ligation: A Chemoselective Click-Type Reaction for Accessing Multifunctional Biomolecular Constructs Author(s): Ulrich S., Boturyn Didier, Marra A., Renaudet Olivier, Dumy P. (Article) Published: Chemistry - A European Journal, vol. 20 p.34 - 41 (2014) |