SMIETANA Michael
Team: Oligonucléotides Modifiés
michael.smietana
umontpellier.fr
0448792047
Room: N1H01, Floor: 1, Build.: Balard - Site : Pôle Chimie Balard Recherche
Research Topics: - chim/chim.inor
- chim
- chim/chim.orga
- sdv/sdv.bbm
- sdv/sdv.bbm/sdv.bbm.bc
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Last scientific productions :
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A multinuclear NMR perspective on the complexation between bisboronic acids and bisbenzoxaboroles with cis -diols
Author(s): Larcher Adèle, Lebrun A., Smietana M., Laurencin Danielle
(Article) Published:
New Journal Of Chemistry, vol. 42 p.2815 - 2823 (2018)
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Detection of short ssDNA and dsDNA by current-voltage measurements using conical nanopores coated with Al2O3 by atomic layer deposition
Author(s): Thangaraj Vidhyadevi, Lepoitevin Mathilde, Smietana M., Balanzat Emmanuel, Bechelany Mikhael, Janot Jean-Marc, Vasseur J.-J., Subramanian Sivanesan, Balme Sébastien
(Article) Published:
Microchimica Acta, vol. 183 p.1011 - 1017 (2016)
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Polyketides
Author(s): Schaefers Françoise, Gulder Tobias A. M., Bressy Cyril, Smietana M., Benedetti Erica, Arseniyadis Stellios, Kalesse Markus, Cordes Martin
Book chapter: Polyketides, vol. p.21-129 (2016)
Ref HAL: hal-01415109_v1
DOI: 10.1002/9781118754085.ch2
Abstract: Polyketides are a fascinating class of natural products with highly diverse, often complex structures combined with a likewise impressive breath of strong and selective biological activities. This chapter discusses the logic of biosynthetic polyketide assembly. It focuses on the introduction of the basic mechanisms and concepts of polyketide core structure assembly using a number of well-studied representative examples, thus allowing to compare the biosynthetic versus chemical synthetic strategies to assemble such beautiful small molecules. Despite the structural diversity of polyketide natural products, there are only few different catalytic domains facilitating a small number of basic reactions common to all types of PKSs that are crucial for product biosynthesis. The structural and functional space covered by bioactive small molecules is further expanded by post-PKS functionalization reactions catalyzed by so-called tailoring enzymes. This includes reorganization of the entire PKS core but also subtle changes by group transfer reactions or oxidative transformations.
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pH-controlled DNA- and RNA-templated assembly of short oligomers.
Author(s): Smietana M.
(Article) Published:
Chemical Science, vol. 6 p.542-547 (2015)
Ref HAL: hal-01101598_v1
DOI: 10.1039/c4sc03028a
Abstract: In the area of artificial genetics the development of non-enzymatic self-organization of synthetic building blocks is critical for both providing biopolymers with extended functions and understanding prebiotic processes. While reversibility is believed to have played a major role in early functional genetic materials, we previously reported an efficient DNA-templated ligation of suitably designed 5′-end boronic acid and 3′-end ribonucleosidic half-sequences. Here, we report the enzyme-free and activation-free DNA- and RNA-templated assembly of bifunctional hexamers. The reversible assembly was found to be regio- and sequence specific and the stabilities of the resulting duplexes were compared to their nicked counterparts. To go further with our understanding of this unprecedented process we also examined an auto-templated duplex self-assembly representing a key step toward the evolution of sequence-defined synthetic polymers.
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Recent developments in alkyne borylations.
Author(s): Smietana M.
(Article) Published:
Tetrahedron / Tetrahedron [London]; Tetrahedron Suppl; Tetrahedron (London), vol. 70 p.8431-8452 (2014)
Ref HAL: hal-01078195_v1
DOI: 10.1016/j.tet.2014.06.026
Abstract: Within the past few decades, organoboron derivatives have become essential intermediates in organic and medicinal chemistry. As a matter of fact, while boronic acids have found wide applications as saccharide sensors1, 2 and 3 self-organizing systems,4, 5, 6 and 7 and medicine,8, 9 and 10 the unique reactivity of the C–B bond has profoundly affected the way organic chemists foresee the construction of carbon–carbon bonds. The contribution of organoboron chemistry to organic chemistry was recognized with two Nobel Prizes awarded in 1979 to Herbert C. Brown and in 2010 to Akira Suzuki who both instigated the development of new synthetic tools for the introduction of boron atoms into organic molecules. Of particular interest are vinylboron species due to their importance in a wide range of applications in natural product total synthesis.11 The stereocontrol of the new carbon–carbon bond is also of high significance. Whereas uncatalyzed and catalyzed processes have already been reviewed in the past,12, 13 and 14 the present report covers mostly recent developments published in the past ten years in the field of metal-free direct and transition metal-catalyzed synthesis of mono-, bis- and metallo-boronate compounds starting from alkynes.13 The mechanistic features and the stereochemical outcome (E/Z nomenclature) will be discussed as well.
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