N'est plus au Laboratoire.
COLACINO Evelina
Fonction : Maitre de Conference, HDR
Thème de Recherche: Chimie Verte
ecolacin
univ-montp2.fr
0467144285
Bureau: 0, Bât: 17 - Site : Faculté des Sciences Triolet
Domaines de Recherche: - Chimie
- Chimie/Chimie thérapeutique
- Chimie/Chimie organique
- Chimie/Matériaux
- Chimie/Catalyse
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Dernieres productions scientifiques :
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Mechanochemistry for “no solvent, no base” preparation of hydantoin-based active pharmaceutical ingredients: nitrofurantoin and dantrolene
Auteur(s): Colacino E., Porcheddu Andrea, halasz ivan, Charnay Clarence, Delogu Francesco, Guerra Ruben, Fullenwarth Julien
(Article) Publié:
Green Chemistry, vol. 20 p.2973 - 2977 (2018)
Ref HAL: hal-01845433_v1
DOI: 10.1039/c8gc01345d
Résumé: The eco-compatible, base- and waste-free, energy-efficient, low-environmental-impact, gram-scale, mechanochemical preparation of marketed drugs such as nitrofurantoin (Furantin©), dantrolene (Dantrium©) and their structurally related derivatives is herein reported. Not a drop of organic solvent was used for the entire process and high yields of pure compounds were obtained without post-reaction work-up. Hydrazones were stable in the presence of water and gaseous HCl, formed as by-products during the synthesis. Comparative mechanochemical experiments were performed using diverse milling devices and jar materials, the active pharmaceutical ingredients were analyzed by PXRD and green metrics are calculated.
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Mechanochemical Preparation of 3,5-Disubstituted Hydantoins from Dipeptides and Unsymmetrical Ureas of Amino Acid Derivatives
Auteur(s): Konnert L., gonnet lori, halasz ivan, Suppo Jean-Simon, Marcia De Figueiredo Renata, Campagne Jean-Marc, Lamaty F., Martinez J., Colacino E.
(Article) Publié:
European Journal Of Organic Chemistry, vol. 81 p.9802-9809 (2016)
Ref HAL: hal-01396871_v1
DOI: 10.1021/acs.joc.6b01832
Résumé: 5-Substituted-3-(alkoxycarbonyl)alkyl-hydantoin derivatives were prepared by mechanochemistry from amino esters or dipeptides, via a 1,1′-carbonyldiimidazole-mediated one-pot/two-step cyclization reaction involving amino acid unsymmetrical urea A and carboxy-imidazolyl-dipeptide ester B intermediates. Comparative experiments in solution were also performed. The successful preparation of an antibacterial agent precursor was also investigated.
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Copper-Containing Rod-Shaped Nanosized Silica Particles for Microwave-Assisted Synthesis of Triazoles in Aqueous Solution
Auteur(s): Najib Mnasri, Nyalosaso Jeff L., Colacino E., Derrien Gaelle, Lamaty F., Martinez J., Zajac Jerzy, Charnay Clarence
(Article) Publié:
Acs Sustainable Chemistry Engineering, vol. p. (2015)
Ref HAL: hal-01207714_v1
DOI: 10.1021/acssuschemeng.5b00661
Résumé: Cu-doped rod-shaped mesoporous silica nanoparticles (Cu-RMSN) were synthesized by a new one-step approach based on in situ functionalization procedure referring to the phenomenon of micellar solubilization. SEM and TEM studies revealed the rod-like morphology of uniformly sized particles with longitudinal mesopore channels. The BET specific surface areas were near 500 m2 g–1 and the average pore diameter varied from 3 to 3.6 nm. The composite Cu-RMSN proved to be an efficient heterogeneous catalyst for a microwave-assisted three-component 1,3-dipolar cycloaddition reaction in aqueous solution. The one-pot preparation of 1,4-dibustituted-1,2,3-triazole derivatives was straightforward and high yielding, due to the high copper dispersion at the pore surface resulting in the high accessibility of the active sites. The efficiency of the catalyst was also demonstrated upon recycling, making such synthesis a truly green process with marked step and solvent economy and important waste reduction.
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Micelles into Glycerol Solvent: Overcoming Side Reactions of Glycerol.
Auteur(s): Hamel Abdellah, Sacco Martina, Mnasri Najib, Lamaty F., Martinez J., De Angelis Francesco, Colacino E., Charnay Clarence
(Article) Publié:
-Acs Sustainable Chem. Eng., vol. 2 p.1353-1358 (2014)
Ref HAL: hal-01000636_v1
DOI: 10.1021/sc500207r
Résumé: The ring-closing metathesis (RCM) of diethyl diallylmalonate in glycerol micellar conditions was studied using microwave irradiation. The micellization of different cationic surfactants in glycerol was first investigated. The results show the superiority of micellar catalysis in glycerol for a RCM reaction compared to glycerol alone, limiting byproduct formation. In comparison with the classical solution syntheses, the method here described allows safer reaction conditions, less hazardous chemical syntheses, and use of renewable feedstocks. The practical workup, separation, and purification operations minimize the use of materials.
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Microwave-ultrasound simultaneous irradiation: a hybrid technology applied to ring closing metathesis.
Auteur(s): Colacino E.
(Article) Publié:
Rsc Advances, vol. 5 p.16878-16885 (2015)
Ref HAL: hal-01114826_v1
DOI: 10.1039/c4ra14938f
Résumé: A new hybrid microwave (MW) and ultrasound (US)-assisted reactor concept was investigated. The 2.45 GHz microwaves were delivered by a semiconductor generator via a coaxial cable to a monomode Transverse Electric (TE) microwave resonant cavity within which the reactor was placed; the US (25 kHz) were delivered at the bottom of the TE cavity via a novel designed sonotrode consisting of a detachable metallic plate-probe (indirect sonication). The semiconductor microwave generator helped to optimize the absorbed energy via its automatic frequency tuning function. The dual MW/US device allowed the use of both technologies separately or in a simultaneous combined manner. The ring-closing metathesis of diethyl diallyl malonate in glycerol micellar conditions was studied as an example using this novel hybrid technology. The results were compared with those obtained when microwaves or ultrasound were applied individually. Various benzylidene-, indenylidene- and Hoveyda–Grubbs-type catalysts were screened. The novel reactor for combined MW/US irradiation showed beneficial effects on the outcome of the reaction.
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