NOTTELET Benjamin
Position : MCU
Team: Biopolymères Artificiels
benjamin.nottelet
univ-montp1.fr
0411759697
Room: 217, Floor: 2, Build.: I - Site : Faculté de pharmacie
Research Topics: - chim/chim.poly
- sdv/sdv.ib/sdv.ib.bio
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Last scientific productions :
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Direct Photomodification of Polymer Surfaces: Unleashing the Potential of Aryl-Azide Copolymers 
Author(s): Schulz A., STOCCO Antonio, Bethry A., Lavigne Jean, Coudane J., Nottelet B.
(Article) Published:
Advanced Functional Materials, vol. 28 p. (2018)
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PLA scaffolds production from Thermally Induced Phase Separation: Effect of process parameters and development of an environmentally improved route assisted by supercritical carbon dioxide
Author(s): Gay S., Lefebvre G., Bonnin M., Nottelet B., Boury F., Gibaud A., Calvignac B.
(Article) Published:
-The Journal Of Supercritical Fluids, vol. 136 p.123 - 135 (2018)
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Modelling of mechanical properties of a PLA-b-PEG-b-PLA biodegradable triblock copolymer during hydrolytic degradation
Author(s): Breche Quentin, Chagnon Grégory, Girard Edouard, Nottelet B., Garric X., Machado Guilherme, Favier Denis
Conference: European Mechanics of Materials Conference (EMMC15) (Bruxelles, BE, 2016-09-07)
Ref HAL: hal-01872434_v1
Abstract: PLA-based biodegradable copolymers are used in many biomedical applications such as temporary implantable devices. Especially, PLA-b-PEG-b-PLA is an excellent candidate for tissue engineering applications. Indeed, it has a good biocompatibility and possesses both mechanical properties of PLA and hydrophilicity of PEG, allowing good properties and degradation time modulation. The main degradation process, for this type of polymers is the hydrolysis of ester links. After the diffusion of water into the polymer bulk, the hydrolysis reaction breaks the polymeric bonds. Modelling of mechanical properties evolution of biodegradable polymers is essential in order to design devices. The aim of this study is to explore and model the viscoelastic properties evolution of a PLA-b-PEG-b-PLA biodegradable copolymer during hydrolytic degradation. The mass decrease, the number average molecular weight and the mechanical properties were studied during 7 degradation weeks. Tensile and relaxation tests in a liquid bath at 37°C were realized at different states of degradation. Stress relaxation is observed, highlighting a viscoelastic behavior for every degradation state. Moreover, the polymer suffers a loss of mechanical properties in the course of degradation. In order to model viscoelastic properties, a generalized Maxwell model is used. This model is first identified on results obtained for non degraded material. Then, based on the invariance of the normalized relaxation curves experimentally observed for the degraded materials, a degradation variable is introduced in the model. Predictions of the model are then compared to experimental results in the course of degradation. The abilities and limits of the model are discussed.
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MRI-visible polymer based on poly(methyl methacrylate) for imaging applications
Author(s): Younis M., Darcos V., Paniagua C., Ronjat P., Lemaire Laurent, Nottelet B., Garric X., Bakkour Youssef, El Nakat John Hanna, Coudane J.
(Article) Published:
Rsc Advances, vol. 6 p.5754-60 (2016)
Ref HAL: hal-01388778_v1
DOI: 10.1039/C5RA23646K
Abstract: Macromolecular contrast agents are very attractive to afford efficient magnetic resonance imaging (MRI) visualization of implantable medical devices. In this work, we report on the grafting of a Gd-based DTPA contrast agent onto a poly(methyl methacrylate) derivative backbone by combining free radical polymerization and copper-catalyzed azide-alkyne cycloaddition (CuAAC). Using free radical polymerization, poly(methyl methacrylate-co-propargyl methacrylate) copolymers were prepared with a control of the ratio in propargyl methacrylate monomer units. The synthesis of a new azido monofunctionalized DTPA ligand was also reported and characterized by 1H NMR and mass spectroscopy. After complexation with gadolinium, this ligand has been grafted on the polymer backbone by click chemistry reaction. The obtained macromolecular contrast agent was then coated on a polypropylene mesh using the airbrushing technique and the mesh was assessed for MRI visualization at 7 teslas. The polymeric contrast agent was also tested for cytocompatibility and stability to assess its suitability for biomedical applications.
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Redox Reducible and Hydrolytically Degradable PEG–PLA Elastomers as Biomaterial for Temporary Drug-Eluting Medical Devices
Author(s): Rupnik Simona, Buwalda S., Déjean S., Bethry A., Garric X., Coudane J., Nottelet B.
(Article) Published:
Macromolecular Bioscience, vol. p. (2016)
Ref HAL: hal-01369303_v1
DOI: 10.1002/mabi.201600132
Abstract: With the aim to develop biomaterials for temporary medical devices, a series of novel reducibleand/or degradable elastomers has been prepared from PLA-b-PEG-b-PLA copolymersphoto-crosslinked with diallyl sulfide or pentaerythritol tetrakis(3-mercaptopropionate).Thermal and mechanical properties, including elastic limit and Young modulus, are assessed.Degradation is then evaluated under standard hydrolytic conditions. Reducibility of a selectedelastomer is then illustrated using 2-mercaptoethanol or glutathione as reducing agents. Theredox-sensitivity of the selected elastomer and the possibility to modulate the degradabilityare shown. Considering drug-eluting elastomeric devices applications, anti-inflammatorydrug ibuprofen loading is illustrated with the two simplest elastomer formulations. A rapidor slow linear release is observed as a function of the low or high molecular weight of the triblockpre-polymers. Finally, the cytocompatibilityof the degradable elastomers is assessedwith regard to their potential to favor orinhibit L929 murine fibroblasts proliferationas a function of the hydrophilicity/hydrophobicityof the triblock copolymers.
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