LEBRUN Aurélien
Fonction : Ingénieur d Etudes en R.M.N.
Service: Plateau Technique
aurelien.lebrun
umontpellier.fr
0467143835
Bureau: , Bât: 17 - Site : Faculté des Sciences Triolet
Domaines de Recherche: - Chimie/Chimie organique
- Chimie/Chimie de coordination
- Chimie/Chimie inorganique
- Chimie/Chimie thérapeutique
- Sciences du Vivant/Cancer
- Chimie/Cristallographie
- Sciences du Vivant/Biochimie, Biologie Moléculaire/Biologie moléculaire
- Sciences du Vivant/Biochimie, Biologie Moléculaire/Biologie structurale
- Sciences du Vivant/Biochimie, Biologie Moléculaire/Biochimie
- Sciences du Vivant/Biochimie, Biologie Moléculaire/Génomique, Transcriptomique et Protéomique
- Chimie/Matériaux
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Dernieres productions scientifiques :
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Vinyl-aziridines and cyclopropanes in Pd-catalyzed (3+2)-cycloaddition reactions with cyclic N-sulfonyl imines
Auteur(s): Spielmann Kim, Tosi Eleonora, Lebrun A., Niel Gilles, Van Der Lee Arie, De Figueiredo Renata Marcia, Campagne Jean-Marc
(Article) Publié:
Tetrahedron / Tetrahedron [London]; Tetrahedron Suppl; Tetrahedron (London), vol. 74 p.6497 - 6511 (2018)
Ref HAL: hal-01892430_v1
DOI: 10.1016/j.tet.2018.09.040
Résumé: Efficient palladium-catalyzed (3 þ 2)-cycloaddition reactions of cyclic N-sulfonyl imines and vinyl-aziridines (or cyclopropanes) have been achieved. The reactions, with either vinylic substrate, proceed with excellent yields affording highly functionalized imidazolidine and pyrrolidine derivatives. The cycloadditions take place via the reaction of zwitterionic p -allyl palladium intermediates with cyclic N-sulfonyl imines through i) the formation of two NeC bonds in the presence of vinylaziridines (synthesis of imidazolidines) and ii) one CeC bond and one NeC bond in the presence of vinylcyclopropanes (synthesis of pyrrolidines). Following on preliminary works on the diastereoselective synthesis of imidazolidines, herein we wish to give a broader view on the subject by describing derivatization reactions and attempts towards an enantioselective version. Moreover, we describe and discuss the behavior of each vinylic substrate (aziridine or cyclopropane) on the (3 þ 2)-cycloaddition reactions. Mechanistic and (intriguing) selectivity outcomes are also going to be discussed.
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Cofacial porphyrin dimers assembled from N-heterocyclic carbene–metal bonds
Auteur(s): Rose Clémence, Lebrun A., Clément Sébastien, Richeter Sébastien
(Article) Publié:
Chemical Communications / Chem Commun (Cambridge), vol. 54 p.9603 - 9606 (2018)
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A multinuclear NMR perspective on the complexation between bisboronic acids and bisbenzoxaboroles with cis -diols
Auteur(s): Larcher Adèle, Lebrun A., Smietana M., Laurencin Danielle
(Article) Publié:
New Journal Of Chemistry, vol. 42 p.2815 - 2823 (2018)
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Porphyrins Conjugated with Peripheral Thiolato Gold(I) Complexes for Enhanced Photodynamic Therapy
Auteur(s): Longevial Jean-François, El Cheikh K., Aggad D., Lebrun A., van der Lee Arie, Tielens Frederik, Clément Sébastien, Morere A., Garcia M., Gary-Bobo M., Richeter Sébastien
(Article) Publié:
Chemistry - A European Journal, vol. 23 p.14017-14026 (2017)
Ref HAL: hal-01613027_v1
DOI: 10.1002/chem.201702975
Résumé: Porphyrins fused to imidazolium salts across two neighboring beta-pyrrolic positions were used as N-heterocycliccarbene (NHC) precursors to anchor AuI-Cl complexes at their periphery. Synthesis of several thiolato-AuI complexes was then achieved by substituting chloride for thiolates. Photodynamic properties of these complexes were investigated: the data obtained show that the Au@S bonds could be cleaved upon irradiation. The proposed mechanism to explain the release of thiolate moiety involves the S atom oxidation by singlet oxygen generated in the course of irradiation. In view of photodynamic therapy (PDT) applications, these porphyrins fused to NHC-AuI complexes were tested as photosensitizers to kill MCF-7 breast cancer cells. Results show the important role played by the ancillary ligands (chloride versus thiolates) on the photodynamic effect.
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Hydrophobic alpha,alpha-Disubstituted Disilylated TESDpg Induces Incipient 3 10 -Helix in Short Tripeptide Sequence
Auteur(s): Fanelli R., Berthomieu Dorothée, Didierjean Claude, Doudouh Abdelatif, Lebrun A., Martinez J., Cavelier F.
(Article) Publié:
Organic Letters, vol. 19 p.2937 - 2940 (2017)
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