Photo de ULRICH Sébastien
ULRICH Sébastien      
Position : Directeur de recherche
Team: Synthèse Glycosidique et Reconnaissance Moléculaire
Room: N2H14, Floor: 2, Build.: Balard - Site : Pôle Chimie Balard Recherche

  • Médaille de bronze CNRS
Research Activities:     
Sébastien Ulrich carried out his PhD in molecular and supramolecular chemistry under the guidance of Pr. Jean-Marie
Lehn (ISIS/Université de Strasbourg, France), developing molecular switches for controlling dynamic combinatorial
libraries. He subsequently joined the groups of Pr. Harry L. Anderson (Oxford University, UK) as an EPSRC fellow
and of Pr. Eric T. Kool (Stanford University, CA, USA) as a Fulbright fellow. In 2011 he was awarded an ANR
starting grant and joined the group of Pr. Pascal Dumy (DCM, Grenoble, France). In 2012, he was recruited as
Research Associate by the CNRS (IBMM, Montpellier, France). In 2014, he was named Junior Distinguished member of the French Chemical Society and, in 2017, was rewarded the CNRS bronze medal. In 2023, he was promoted Directeur de Recherche by the CNRS.

-Axis 1 : Dynamic and adaptive systems for the drug & gene delivery.
-Axis 2 : Biomolecular Self-Assemblies: self-organization of small molecules on nucleic acid templates, hierarchical self-assembly of cages/polymers/networks.

Mihail BARBOIU, IEM-Université de Montpellier, France
Nadir BETTACHE/Magali GARY-BOBO, IBMM-Université de Montpellier, France
Prisca BOISGUERIN, PhyMedExp, Montpellier, France
Fabien COUGNON, University of Jyväskylä, Finlande
Yann FERRAND, CBMN, Bordeaux, France
Virginie GERVAIS, I2BC CNRS/CEA/Université Paris-Saclay, France
Loic JIERRY/Pierre SCHAAF, ICS, Strasbourg, France
Laurent KREMER, IRIM, Montpellier, France
Jérôme LACOUR, Université de Genève, Suisse
Frédéric LAMATY, IBMM, Montpellier, France
Jeanne LEBLOND CHAIN, ARNA, INSERM, Université de Bordeaux, France
Zbigniew PIANOWSKI, KIT, Karlsruhe, Allemagne
Sébastien RICHETER/Sébastien CLEMENT, ICGM-Université de Montpellier, Montpellier, France
Sandrine SAGAN/Emmanuelle SACHON/Fabienne BURLINA/Astrid WALRANT/Françoise ILLIEN, LBM, Sorbonne Université, Paris, France
Artur STEFANKIEWICZ, Adam Mickiewicz University, Poznañ, Poland
Mathieu SURIN, Université de Mons, Belgium
Yann TROLEZ, ICSR, Rennes, France
Ghislaine VANTOMME, Eindhoven University of Technology, Pays-Bas
Max VON DELIUS, University of Ulm, Germany

LIST OF PUBLICATIONS (updated January 2024):


57) Self-assembled porphyrin–peptide cages for photodynamic therapy, C. Ghosh, L. M. A. Ali, Y. Bessin, S. Clément, S. Richeter, N. Bettache, S. Ulrich, Org. Biomol. Chem., 2024, DOI 10.1039/D3OB01887C. link
56) Dynamic covalent synthesis, F. B. L. Cougnon, A. R. Stefankiewicz, S. Ulrich, Chem. Sci., 2024, 15, 879-895. link


55) If order can be, order will be - Retour sur les 2èmes Journées de Chimie Supramoléculaire, D. Bourgeois, S. Ulrich, L’Actualité Chimique, 2023, 487, 4-5. link
54) Bis-Alkylureido Imidazole Artificial Water Channels, D.-D. Su, S. Ulrich, M. Barboiu, Angew. Chem. Int. Ed., 2023, 62, 35, e202306265. link
53) Nucleic-Acid-Templated Synthesis of Smart Polymer Vectors for Gene Delivery, J. García Coll, S. Ulrich, ChemBioChem, 2023, 24, 19, e202300333. link
52) A triazolium-anchored self-immolative linker enables self-assembly-driven siRNA binding and esterase-induced release, S. Hollstein, L. M. A. Ali, M. Coste, J. Vogel, N. Bettache, S. Ulrich, M. von Delius, Chem. Eur. J., 2023, 29, 8, e202203311. link
51) Complexation Preferences of Dynamic Constitutional Frameworks as Adaptive Gene Vectors, D. Su, V. Gervais, S. Ulrich, M. Barboiu, Chem. Eur. J., 2023, 29, 8, e202203062. link
50) Structure-Activity Relationships in Nucleic-Acid-Templated Vectors Based on Peptidic Dynamic Covalent Polymers, D. Su, L. M. A. Ali, M. Coste, N. Laroui, Y. Bessin, M. Barboiu, N. Bettache, S. Ulrich, Chem. Eur. J., 2023, 29, 7, e202202921. link


49) Fluorescent Dynamic Covalent Polymers for DNA Complexation and Templated Assembly, C. Kotras, M. Leclercq, M. Roger, C. Bouillon, A. Recupido, A. Lebrun, Y. Bessin, P. Gerbier, S. Richeter, S. Ulrich, S. Clément, M. Surin, Molecules, 2022, 27 (19), 6648. link
48) Squalene–polyethyleneimine–dynamic constitutional frameworks enhancing the enzymatic activity of carbonic anhydrase, D. Su, K. Aissou, Y. Zhang, V. Gervais, S. Ulrich, M. Barboiu, Catal. Sci. Technol., 2022, 12, 3094-3101. link
47) Quadruple Functionalization of a Tetraphenylethylene Aromatic Scaffold with Ynamides or Tetracyanobutadienes: Synthesis and Optical Properties, C. Philippe, M. Coste, Y. Bretonnière, L. Lemiègre, S. Ulrich, Y. Trolez, Eur. J. Org. Chem., 2022, e202200049. link
46) Hierarchical Self-Assembly of Aromatic Peptide Conjugates into Supramolecular Polymers: it takes two to tango, M. Coste, E. Suárez-Picado, S. Ulrich, Chem. Sci., 2022, 13, 909-933. link
45) Hierarchical self-assembly and multi-dynamic responsiveness of fluorescent dynamic covalent networks forming organogels, E. Suárez-Picado, M. Coste, J.-Y. Runser, M. Fossépré, A. Carvalho, M. Surin, L. Jierry, S. Ulrich, Biomacromolecules, 2022, 23, 1, 431-442. link


44) Constitutional Dynamic Inhibition/Activation of Carbonic Anhydrases, D. Su, Y. Zhang, S. Ulrich, M. Barboiu, ChemPlusChem, 2021, 86, 11, 1500-1510. link
43) Synthesis, self-assembly and nucleic acid recognition of an acylhydrazone-conjugated cationic tetraphenylethene ligand, M. Coste, C. Kotras, Y. Bessin, V. Gervais, D. Dellemme, M. Leclercq, M. Fossépré, S. Richeter, S. Clément, M. Surin, S. Ulrich, Eur. J. Org. Chem., 2021, 7, 1123-1135. link
42) Cell‐selective siRNA delivery using glycosylated dynamic covalent polymers self‐assembled in situ by RNA‐templating, N. Laroui, M. Coste, D. Su, L. Ali, Y. Bessin, M. Barboiu, M. Gary-Bobo, N. Bettache, S. Ulrich, Angew. Chem. Int. Ed., 2021, 60, 11, 5783-5787. link


41) Cationic Dynamic Covalent Polymers for Gene Transfection, D. Su, M. Coste, A. Diaconu, M. Barboiu, S. Ulrich, J. Mater. Chem. B, 2020, 8, 9385-9403. link
40) From Interaction to Function in DNA‐Templated Supramolecular Self‐Assemblies, M. Surin, S. Ulrich, ChemistryOpen, 2020, 9, 480-498. link
39) Dynamic covalent polymers for biomedical applications, Y. Zhang, Y. Qi, S. Ulrich, M. Barboiu, O. Ramström, Materials Chemistry Frontiers, 2020, 4, 489-506. link


38) Combination of photodynamic therapy and gene silencing achieved through the hierarchical self-assembly of porphyrin-siRNA complexes. N. Laroui, M. Coste, L. Lichon, Y. Bessin, M. Gary-Bobo, G. Pratviel, C. Bonduelle, N. Bettache, S. Ulrich, Int. J. Pharm., 2019, 569, 118585. link
37) Tuning the Solubility of Self-Assembled Fluorescent Aromatic Cages Using Functionalized Amino Acid Building Blocks. M. Konopka, P. Cecot, S. Ulrich, A. R. Stefankiewicz, Front. Chem., 2019, 7, Article 503. link
36) A cationic tetraphenylethene as a light-up supramolecular probe for DNA G-quadruplexes. C. Kotras, M. Fossepre, M. Roger, V. Gervais, S. Richeter, P. Gerbier, S. Ulrich, M. Surin, S. Clément, Front. Chem., 2019, 7, Article 493. link
35) Growing Prospects of Dynamic Covalent Chemistry in Delivery Applications. S. Ulrich, Acc. Chem. Res., 2019, 52, 2, 510-519. link


34) Biomolecular Dynamic Covalent Polymers for DNA complexation and siRNA delivery. C. Bouillon, Y. Bessin, F. Poncet, M. Gary-Bobo, P. Dumy, M. Barboiu, N. Bettache, S. Ulrich, J. Mater. Chem. B., 2018, 7239-7246. link
33) Multivalent metallosupramolecular assemblies as effective DNA binding agents. W. Drożdż, A. Walczak, Y. Bessin, V. Gervais, X.‐Y. Cao, J.‐M. Lehn, S. Ulrich, A. R. Stefankiewicz, Chem. Eur. J., 2018, 24, 10802-10811. link
32) Auto-assemblages dynamiques pour la reconnaissance et la vectorisation d’acides nucleiques. S. Ulrich, L’Actualité Chimique, 2018, 430-431, 61-67. link
31) Self-assembly and chiroptical properties in supramolecular complexes of adenosine phosphates and guanidinium-bispyrene. M. Trévisan, M. Fossépré, D. Paolantoni, J. Rubio‐Magnieto, P. Dumy, S. Ulrich, M. Surin, Chirality, 2018, 30 (6), 719-729. link
30) Switching multivalent DNA complexation using metallo-controlled cationic supramolecular self-assemblies. W. Drożdż, Y. Bessin, V. Gervais, X.-Y. Cao, J.-M. Lehn, A. R. Stefankiewicz, S. Ulrich, Chem. Eur. J., 2018, 24 (7), 1518-1521. link
29) Photomodulation of DNA-templated supramolecular assemblies. J. Rubio-Magnieto, T.-A. Phan, M. Fossépré, V. Matot, J. Knoops, T. Jarrosson, P. Dumy, F. Serein-Spirau, C. Niebel, S. Ulrich, M. Surin, Chem. Eur. J., 2018, 24 (3), 706-714. link


28) Generation of Multicomponent Molecular Cages using Simultaneous Dynamic Covalent Reactions. W. Drożdż, C. Bouillon, C. Kotras, S. Richeter, M. Barboiu, S. Clément, A. R. Stefankiewicz, S. Ulrich, Chem. Eur. J., 2017, 23, 18010-18018. link
27) Polyhedral oligomeric silsesquioxane (POSS) bearing glyoxylic aldehyde as clickable platform towards multivalent conjugates. N. Kanfar, A. Mehdi, P. Dumy, S. Ulrich, J.-Y. Winum, Chem. Eur. J., 2017, 23, 17867-17869. link
26) One-Pot Self-Assembly of Peptide-Based Cage-Type Nanostructures using Orthogonal Ligations. E. Bartolami, J. Knoops, Y. Bessin, M. Fossépré, J. Chamieh, P. Dumy, M. Surin, S. Ulrich, Chem. Eur. J., 2017, 23, 14323-14331. link
25) Effective Access to Multivalent Inhibitors of Carbonic Anhydrases Promoted by Peptide Bioconjugation. N. Kanfar, M. Tanc, P. Dumy, C. T. Supuran, S. Ulrich, J.-Y. Winum, Chem. Eur. J., 2017, 23 (28), 6788-6794. link
24) Auto-assemblage dynamique de clusters cationiques pour la complexation et la vectorisation d’acides nucléiques. E. Bartolami, S. Ulrich, P. Dumy, L’Actualité Chimique, 2017, 417. link


23) Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution. C. S. Hwang, L. Xu, W. Wang, S. Ulrich, L. Zhang, J. Chong, J. H. Shin, X. Huang, E. T. Kool, C. E. McKenna, D. Wang, Nucl. Acids Res., 2016, 44 (8), 3820-3828. link
22) Bioactive clusters promoting cell penetration and nucleic acids complexation for drug and gene delivery applications: from designed to self-assembled and responsive systems. E. Bartolami, C. Bouillon, P. Dumy, S. Ulrich, Chem. Commun., 2016, 52, 4257-4273. link
21) A metal-free synthetic approach to peptide-based iminosugar clusters as novel multivalent glycosidase inhibitors. R. Zelli, E. Bartolami, J.-F. Longevial, Y. Bessin, P. Dumy, A. Marra, S. Ulrich, RSC Adv., 2016, 6, 2210-2216. link


20) Emerging trends in enzyme inhibition by multivalent nanoconstructs. N. Kanfar, E. Bartolami, R. Zelli, A. Marra, J.-Y. Winum, S. Ulrich, P. Dumy, Org. Biomol. Chem., 2015, 13, 9894-9906. link
19) Multivalent DNA recognition by self-assembled clusters: deciphering structural effects by fragments screening and evaluation as siRNA vectors. E. Bartolami, Y. Bessin, N. Bettache, M. Gary-Bobo, M. Garcia, P. Dumy, S. Ulrich, Org. Biomol. Chem., 2015, 13, 9427-9438 (themed collection: Multivalent Biomolecular Recognition). link
18) Dynamic expression of DNA complexation with self-assembled biomolecular clusters. E. Bartolami, Y. Bessin, V. Gervais, P. Dumy, S. Ulrich, Angew. Chem. Int. Ed., 2015, 54 (35), 10183-10187. link
17) Fluorescent silica nanoparticles with multivalent inhibitory effects towards carbonic anhydrases. N. Touisni, N. Kanfar, S. Ulrich, P. Dumy, C.T. Supuran, A. Mehdi, J.-Y. Winum, Chem. Eur. J., 2015, 21 (29), 10306-10309. link
16) Synthesis of a-PNA containing a functionalized triazine as nucleobase analogue. E. Bartolami, A. Gilles, P. Dumy, S. Ulrich, Tetrahedron Lett., 2015, 56 (18), 2319-2323. link
15) A Dynamic Combinatorial Approach for Identifying Side Groups that Stabilize DNA-Templated Supramolecular Self-Assemblies. D. Paolantoni, S. Cantel, P. Dumy, S. Ulrich, Int. J. Mol. Sci., 2015, 16, 3609-3625 (special issue "Supramolecular interactions"). link


14) Probing the importance of π-stacking interactions in DNA-templated self-assembly of bisfunctionalized guanidinium compounds. D. Paolantoni, J. Rubio-Magnieto, S. Cantel, J. Martinez, P. Dumy, M. Surin, S. Ulrich, Chem. Commun., 2014, 50, 14257-14260. link
13) Degradable Hybrid Materials Based on Cationic Acylhydrazone Dynamic Covalent Polymers Promote DNA Complexation through Multivalent Interactions. C. Bouillon, D. Paolantoni, J. C. Rote, Y. Bessin, L. W. Peterson, P. Dumy, S. Ulrich, Chem. Eur. J., 2014, 20 (45), 14705-14714. link
12) Probing Secondary Interactions in Biomolecular Recognition by Dynamic Combinatorial Chemistry. S. Ulrich, P. Dumy, Chem. Commun., 2014, 50 (44), 5810-5825 (“Systems chemistry: a web themed issue”). link
11) Theoretical and Structural Analysis of Long C–C Bonds in the Adducts of Polycyanoethylene and Anthracene Derivatives and their Connection to the Reversibility of Diels–Alder Reactions. A. K. H. Hirsch, P. Reutenauer, M. Le Moignan, S. Ulrich, P. J. Boul, J. M. Harrowfield, P. D. Jarowski, J.-M. Lehn, Chem. Eur. J., 2014, 20 (4), 1073-1080. link
10) Oxime Ligation: a Chemoselective Click-Type Reaction for Accessing Multifunctional Biomolecular Constructs. S. Ulrich, D. Boturyn, A. Marra, O. Renaudet, P. Dumy, Chem. Eur. J., 2014, 20 (1), 34-41. link


9) Engineering of biomolecules for sensing and imaging applications. S. Ulrich, P. Dumy, D. Boturyn, O. Renaudet, J. Drug Del. Sci. Tech., 2013, 23 (1), 5-15. link


8) Biodistribution and Pharmacokinetic Studies of a Porphyrin Dimer Photosensitizer (Oxdime) by Fluorescence Imaging and Spectroscopy in Mice Bearing Xenograft Tumors, M. Khurana, S. Ulrich, A. Kim, Y. Moriyama, G. Netchev, M. K. Akens, H. L. Anderson, B. C. Wilson, Photochem. Photobiol., 2012, 88, 1531-1538. link
7) Dissecting Chemical Interactions Governing RNA Polymerase II Transcriptional Fidelity, M. W. Kellinger, S. Ulrich, J. Chong, E. T. Kool, D. Wang, J. Am. Chem. Soc., 2012, 134, 8231-8240. link


6) Importance of Steric Effects on the Efficiency and Fidelity of Transcription by T7 RNA Polymerase, S. Ulrich, E. T. Kool, Biochemistry, 2011, 50 (47), 10343-10349. link


5) Metallo-controlled Dynamic Molecular Tweezers: Design, Synthesis, and Self-assembly by Metal-ion Coordination, S. Ulrich, A. Petitjean, J.-M. Lehn, Eur. J. Inorg. Chem., 2010, 13, 1913-1928. link


4) Adaptation and Optical Signal Generation in a Constitutional Dynamic Network, S. Ulrich, J.-M. Lehn, Chem. Eur. J., 2009, 15, 5640-5645. link
3) Adaptation to Shape Switching by Component Selection in a Constitutional Dynamic System, S. Ulrich, J.-M. Lehn, J. Am. Chem. Soc., 2009, 131, 5546-5559. link
2) Reversible Constitutional Switching between Macrocycles and Polymers Induced by Shape Change in a Dynamic Covalent System, S. Ulrich, E. Buhler, J.-M. Lehn, New. J. Chem., 2009, 33, 271-292. link


1) Reversible Switching between Macrocyclic and Polymeric States by Morphological Control in a Constitutional Dynamic System, S. Ulrich, J.-M. Lehn, Angew. Chem. Int. Ed., 2008, 47, 2240-2243. link
Research Topics:
  • chim/chim.orga
  • chim
Scientific productions :
+ Photomodulation of DNA-Templated Supramolecular Assemblies doi link

Author(s): Rubio-Magnieto Jenifer, Phan Tuan-Anh, Fossépré Mathieu, Matot Valérie, Knoops Jeremie, Jarrosson Thibaut, Dumy P., Serein-Spirau Françoise, Niebel Claude, Ulrich S.(Corresp.), Surin Mathieu

(Article) Published: Chemistry - A European Journal, vol. 24 p.706-714 (2018)

+ Generation of Multicomponent Molecular Cages using Simultaneous Dynamic Covalent Reactions doi link

Author(s): Drożdż Wojciech, Bouillon C., Clément Clément, Richeter Sébastien, Barboiu Mihail, Clément Sébastien, Stefankiewicz Artur R., Ulrich S.

(Article) Published: Chemistry - A European Journal, vol. 23 p.18010 - 18018 (2017)

+ Oxime Ligation: A Chemoselective Click-Type Reaction for Accessing Multifunctional Biomolecular Constructs doi link

Author(s): Ulrich S., Boturyn Didier, Marra A., Renaudet Olivier, Dumy P.

(Article) Published: Chemistry - A European Journal, vol. 20 p.34 - 41 (2014)