N'est plus au Laboratoire.
DEWYNTER Georges
Thème de Recherche: Synthèses Stéréosélectives & Acides Aminés Modifiés
dewynter
univ-montp2.fr
0467144819
Bureau: 0, Bât: 17 - Site : UM2
Domaines de Recherche: - Chimie
- Chimie/Chimie organique
- Chimie/Cristallographie
- Chimie/Chimie inorganique
|
Dernieres productions scientifiques :
|
|
Synthesis of Diastereomeric Pyrrolidine Sulfamides via Anchimerically Assisted Nucleophilic Substitution Reactions
Auteur(s): Vargas-Caporali Jorge, Van Der Lee Arie, Dewynter G., Juaristi Eusebio
(Article) Publié:
Letters In Organic Chemistry, vol. 15 p.352 - 358 (2018)
|
|
|
Enantiodivergent Transannular Rearrangement of 3-Isopropyl-1,4-benzodiazepine-2,5-dione by Memory of Chirality
Auteur(s): Dewynter G.
(Article) Publié:
European Journal Of Organic Chemistry, vol. 2011 p.2043-2047 (2011)
Ref HAL: hal-00602467_v1
DOI: 10.1002/ejoc.201100030
Résumé: An unprecedented reactivity has been introduced to 3-isopropyl-1,4-benzodiazepine-2,5-dione thanks to N-Boc activation. Under basic conditions, a transannular rearrangement occurred by ring contraction to furnish a 3-aminoquinoline-2,4-dione with good to excellent enantiomeric purity. Depending on the nature of the base, either enantiomer can be obtained in a stereocontrolled manner. This enantiodivergent synthesis could be assigned to the conformational equilibrium of the starting material, which was studied with the help of DFT calculations.
|
|
|
Cyclosulfamide as a chiral auxiliary: application to efficient asymmetric synthesis (alkylation/aldolization)
Auteur(s): Dewynter G.
(Article) Publié:
Tetrahedron Asymmetry, vol. 21 p.2361-2366 (2010)
Ref HAL: hal-00533621_v1
DOI: 10.1016/j.tetasy.2010.09.001
Résumé: The chiral cyclosulfamide (S)-2-benzyl-4-isopropyl-1,2,5-thiadiazolidine 1,1-dioxide was designed as a chimera of Evans and Oppolzer chiral auxiliaries. The N-propionyl derivative appeared to be very powerful for the stereocontrolled synthesis of chiral building blocks through asymmetric aldolization and alkylation reactions.
|
|
|
Regioselective and sequential reactivity of activated 2,5-diketopiperazines
Auteur(s): Dewynter G.
(Article) Publié:
Journal Of Peptide Science, vol. 15 p.474-478 (2009)
Ref HAL: hal-00390590_v1
Résumé: The electrophilic reactivity of Boc-DKPs has been studied. Thanks to Boc activation, the opening ability of carbonyl lactam groups is enhanced. According to experimental conditions, this enabled the synthesis of Boc-amino acid derivatives or original dipeptides via a regioselective and sequential way.
|
|
|
Activated sulfahydantoin as Boc-glycine enolate equivalent: highly diastereoselective alpha-hydroxyalkylation and application to the synthesis of aldopentonate analogues
Auteur(s): Dewynter G.
(Article) Publié:
Tetrahedron Letters, vol. 50 p.1100-1104 (2009)
Ref HAL: hal-00360907_v1
DOI: 10.1016/j.tetlet.2008.12.070
Résumé: N-Boc-activated sulfahydantoin can be seen as glycine enolate equivalent. It appeared as a convenient starting material for the stereocontrolled preparation of threonine homologues through an alkaline syn aldolization involving a Boc migration. The methdology allowed the one-pot preparation of constrained analogues of polyoxamic
|
Plus...