N'est plus au Laboratoire.
AGGAD Dina
dina.aggad
umontpellier.fr
0467140000
Domaines de Recherche: - Chimie
- Sciences du Vivant/Biologie cellulaire
- Chimie/Matériaux
- Chimie/Chimie thérapeutique
- Chimie/Chimie de coordination
- Sciences du Vivant/Cancer
- Chimie/Chimie organique
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Dernieres productions scientifiques :
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Hollow Organosilica Nanoparticles for Drug Delivery
Auteur(s): Rahmani Saher, Akrout Alia, Budimir Jelena, Aggad D., Daurat M., Godefroy A., Nguyen C., Largot Hanene, Gary-Bobo M., Raehm Laurence, Durand Jean-Olivier, Charnay Clarence
(Article) Publié:
-Chemistryselect, vol. 3 p.10439 - 10442 (2018)
Ref HAL: hal-01902727_v1
DOI: 10.1002/slct.201802107
Résumé: The sol‐gel synthesis of hollow organosilica nanoparticles incorporating amino groups with uniform size are described. These nanoparticles were successfully prepared via a microemulsion method. Then, the hollow nanoparticles were loaded with gemcitabine hydrochloride or methotrexate and studied in MCF‐7 breast cancer cells.
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PEGylation rate influences peptide-based nanoparticles mediated siRNA delivery in vitro and in vivo
Auteur(s): Aldrian Gudrun, Vaissière Anaïs, Konate Karidia, Seisel Quentin, Vivès Eric, Fernandez Frédéric, Viguier Véronique, Genevois Coralie, Couillaud Franck, Démèné Héléne, Aggad D., Covinhes Aurélie, Barrère-Lemaire Stéphanie, Deshayes Sébastien, Boisguerin Prisca
(Article) Publié:
Journal Of Controlled Release, vol. 256 p.79--91 (2017)
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Biocompatible Periodic Mesoporous Ionosilica Nanoparticles with Ammonium Walls: Application to Drug Delivery
Auteur(s): Bouchal Roza, Daurat M., Gary-Bobo M., Da Silva A., Lesaffre L., Aggad D., Godefroy A., DIEUDONNE-GEORGE Philippe, Charnay Clarence, Durand Jean-Olivier, Hesemann Peter
(Article) Publié:
Acs Applied Materials Interfaces, vol. 9 p.32018-32025 (2017)
Ref HAL: hal-01625845_v1
DOI: 10.1021/acsami.7b07264
Résumé: Periodic mesoporous ionosilica nanoparticles with ammonium wallswere synthesized exclusively from a trisilylated ammonium precursor. The nanoparticlesdisplay a uniform particle size, together with a high specific surface area and anordered hexagonal pore architecture. Completely biocompatible in vitro and in vivo,the nanoparticles are efficiently endocytosed by RAW 264.7 macrophages and used ascarrier vehicles for anionic drugs. Diclofenac-loaded ionosilica nanoparticles are veryefficient in inhibiting lipopolysaccharides-induced inflammation.
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Porphyrins Conjugated with Peripheral Thiolato Gold(I) Complexes for Enhanced Photodynamic Therapy
Auteur(s): Longevial Jean-François, El Cheikh K., Aggad D., Lebrun A., van der Lee Arie, Tielens Frederik, Clément Sébastien, Morere A., Garcia M., Gary-Bobo M., Richeter Sébastien
(Article) Publié:
Chemistry - A European Journal, vol. 23 p.14017-14026 (2017)
Ref HAL: hal-01613027_v1
DOI: 10.1002/chem.201702975
Résumé: Porphyrins fused to imidazolium salts across two neighboring beta-pyrrolic positions were used as N-heterocycliccarbene (NHC) precursors to anchor AuI-Cl complexes at their periphery. Synthesis of several thiolato-AuI complexes was then achieved by substituting chloride for thiolates. Photodynamic properties of these complexes were investigated: the data obtained show that the Au@S bonds could be cleaved upon irradiation. The proposed mechanism to explain the release of thiolate moiety involves the S atom oxidation by singlet oxygen generated in the course of irradiation. In view of photodynamic therapy (PDT) applications, these porphyrins fused to NHC-AuI complexes were tested as photosensitizers to kill MCF-7 breast cancer cells. Results show the important role played by the ancillary ligands (chloride versus thiolates) on the photodynamic effect.
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Nanodiamond–PMO for two-photon PDT and drug delivery
Auteur(s): Mauriello-Jimenez Chiara, Knezevic Nikola Z., Galan Rubio Yolanda, Szunerits Sabine, Boukherroub Rabah, Teodorescu Florina, Croissant Jonas G., Hocine Ouahiba, Seric Martina, Raehm Laurence, Stojanovic V., Aggad D., Maynadier M., Garcia M., Gary-Bobo M., Durand Jean-Olivier
(Article) Publié:
-Journal Of Materials Chemistry B Materials For Biology And Medicine, vol. 4 p.5803-5808 (2016)
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