DUPOUY Christelle
Thème de Recherche: Oligonucléotides Modifiés
christelle.dupouy
umontpellier.fr
0448792052
Bureau: N1H11 - Site : Pôle Chimie Balard Recherche
Productions scientifiques :
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Synthèse d'analogues fluorés d'oligonucléotides
Auteur(s): DIALLO Abdoul Gadiry, Lequeux Thierry, Pfund Emmanuel, Dupouy C., Rouanet S., Jean-Jacques Vasseur
Conference: JNOEJC (Lille, FR, 2018-06-06)
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Synthèse d'analogues fluorés de nucleotides
Auteur(s): Pfund Emmanuel, Dupouy C., Lequeux Thierry, Vasseur J.-J., Rouanet S., Bonnet Romaric, bessières Maxime, plihon sebastien
Conference: CFCF (Murol, FR, 2017-05-15)
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Metallophyte wastes and polymetallic catalysis: a promising combination in green chemistry. The illustrative synthesis of 5'-capped RNA
Auteur(s): Thillier Y., Losfeld Guillaume, Escande Vincent, Dupouy C., Vasseur J.-J., Debart F., Grison Claude
(Article) Publié:
Journal And Proceedings Of The Royal Institute Of Chemistry, vol. 3 p.5204-5212 (2013)
Ref HAL: hal-00805661_v1
DOI: 10.1039/c3ra23115a
Résumé: The compatibility of metallic catalysts derived from plants was studied for the chemical solid-phase synthesis of a high added-value biomolecule: 59-capped RNA (GpppRNA or 7mGpppRNA) involved in many essential biological processes. These molecules are of great interest for biologists for structural and mechanistic studies of their complexes with RNA capping enzymes. Several polymetallic catalysts were prepared from various metallophytes species growing in mine sites in a context of phytoremediation programs. Their catalytic efficacy was evaluated for the coupling reaction of guanosine diphosphate (GDP) with a preactivated 5'-monophosphate hexathymidylate (pT6) or a pRNA to form 5'-GpppT6 or 5'-GpppRNA respectively. The direct coupling of 7mGDP with pRNA was also investigated. With Znenriched catalysts obtained from Zn metallophytes, the capping yields were better than those obtained with conventional catalyst ZnCl2. Interestingly with Ni-enriched plant extracts the yield was higher than with NiCl2, a polymetallic catalysis was certainly involved. With this plant-inspired catalysis, metallophytes wastes become efficient and greener polymetallic catalysts. Finally, environmental benefits and effectiveness can be combined.
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