MARTI-MESTRES Gilberte
Fonction : Professeur d université
Thème de Recherche: Pharmacologie Cellulaire
gilberte.marti-mestres
umontpellier.fr
0411759446
Bureau: 0, Etg: 3, Bât: c - Site : Faculté de pharmacie
Productions scientifiques :
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The "in vitro" percutaneous penetration of three antioxidant compounds
Auteur(s): Marti-Mestres G., Mestres J P, Bres J, Martin S, Ramos J, Vian L.
(Article) Publié:
International Journal Of Pharmaceutics, vol. 331 p.139-144 (2007)
Résumé: Caffeic acid, chlorogenic acid and oraposide, a natural glycoside, are phenyl-propanoid compounds. These natural products have been reported to have antioxidant activities such as the scavenging of superoxide anions and hydroxyl radicals. These compounds could be used in the dermocosmetic field to protect the skin from oxidative stress induced by UV radiation. To this end, the permeation of caffeic acid, chlorogenic acid, and oraposide, through pig-ear skin was evaluated in vitro. The percutaneous permeation of these three compounds through pig skin was measured and compared using Franz diffusion cells. At appropriate intervals, up to 72 h, diffusion samples were analyzed using an HPLC assay. After 48 It of drug contact the permeation was also evaluated with a fluorescent microscope on vertical microtomed pig skin sections. In this study on excised pig skin, the flux value was found to be equal to 0.32 and 0.48 mu g cm(-2) h(-1) for caffeic and chlorogenic acids, respectively; for oraposide the levels were below the limit of detection and the flux was not evaluated. These results were corroborated by fluorescent microscopy. Caffeic and chlorogenic acids were found in all skin sections, and these might represent a systemic activity, whereas oraposide remained in the upper superficial layer of the skin. This latter phenomenon seems to be interesting for dermocosmetic applications. (c) 2006 Elsevier B.V. All rights reserved.
Commentaires: 142FF Times Cited:0 Cited References Count:22
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EO/EP copolymer membranes as reservoir in a transdermal therapeutic system for caffeine and vitamin E delivery: modeling and simulation
Auteur(s): Mourgues A, Michele L, Charmette C, Sanchez J, Marti-Mestres G., Gramain P
(Article) Publié:
Desalination, vol. 200 p.127-129 (2006)
Commentaires: 113SA Times Cited:0 Cited References Count:2
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Skin constituents as cosmetic ingredients. Part III: A molecular modeling study of bio-mimetic monoglycerides behavior at the squalene-water interface
Auteur(s): Blasco L, Duracher L., Forestier J P, Vian L., Marti-Mestres G.
(Article) Publié:
Journal Of Dispersion Science And Technology, vol. 27 p.817-824 (2006)
Résumé: The molecular modeling study described here revisits the experimental work that focused on the interfacial properties of different monoglycerides at the squalene/water interface.() The use of molecular modeling software programs allowed the determination of new parameters and provided a better understanding of the behavior of those amphiphilic molecules at the interface of the two non-miscible liquids. Each monoglyceride studied has been characterized by an HLVB value; the curvature radius, R-C; the area of the droplets formed, A(G); the number of monoglyceride molecules required to form a droplet, N; and the distance separating surfactant molecules at the interface, d. The analysis of those different parameters shows that short hydrocarbon chain monoglycerides, such as those having one or more unsaturations and those having a grafted hydroxyl function in the middle of their chain, are excellent surfactants. These configurations promote the efficient reduction of surface tension existing at the squalene/water interface.
Commentaires: 054YH Times Cited:0 Cited References Count:9
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Skin constituents as cosmetic ingredients. Part II: A study of bio-mimetic monoglycerides behavior at the squalene-water interface by the "pendant drop" method in a dynamic mode
Auteur(s): Blasco L, Duracher L., Forestier J P, Vian L., Marti-Mestres G.
(Article) Publié:
Journal Of Dispersion Science And Technology, vol. 27 p.811-815 (2006)
Résumé: This work aims at presenting the viscoelastic behavior of bio-mimetic monoglycerides used as emulsifier in a mixture made of two non-miscible liquids, squalene and water. The measurement of the interfacial tension, carried out by the "pendant drop method in "dynamic mode, made it possible to characterize these amphiphilic molecules according to the value of their elastic modulus, epsilon, as well as their relaxation time, tau(R). The analysis of these parameters, as well as those developed in the previous publication shows that the hydrocarbon chain structure, such as its length, the presence of one or more unsaturations, hydroxyl function, affects the behavior of surfactant molecules at the squalene/water interface.
Commentaires: 054YH Times Cited:0 Cited References Count:6
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