MATHE Christophe
Fonction : Maître de Conférences
Thème de Recherche: Nucléosides & Effecteurs Phosphorylés
christophe.mathe
umontpellier.fr
0467144776
Bureau: 0, Bât: 17 - Site : UM2
Dernieres productions scientifiques :
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New carbocyclic nucleoside analogues with a bicyclo[2.2.1]heptane fragment as sugar moiety; synthesis, X-ray crystallography and anticancer activity. 
Auteur(s): Tănase Constantin I, Drăghici Constantin, Căproiu Miron Teodor, Sergiu Shova, Mathe C., Cocu Florea G, Enache Cristian, Maganu Maria
(Article) Publié:
Bioorganic & Medicinal Chemistry Letters / Bioorganic And Medicinal Chemistry Letters, vol. 22 p.513-22 (2014)
Ref HAL: hal-00947583_v1
PMID 24280070
DOI: 10.1016/j.bmc.2013.10.056
Résumé: An amine group was synthesized starting from an optically active bicyclo[2.2.1]heptane compound, which was then used to build the 5 atoms ring of a key 6-chloropurine intermediate. This was then reacted with ammonia and selected amines obtaining new adenine- and 6-substituted adenine conformationally constrained carbocyclic nucleoside analogues with a bicyclo[2.2.1]heptane skeleton in the sugar moiety. X-ray crystallography confirmed an exo-coupling of base to the ring and a L configuration of the nucleoside analogues. The compounds were tested for anticancer activity.
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Stereospecific synthesis of (-)-neplanocin F
Auteur(s): Ropero S R, Edmont D, Mathe C., Perigaud C.
(Article) Publié:
Nucleosides Nucleotides & Nucleic Acids, vol. 26 p.1111-1114 (2007)
Résumé: The stereospecfic synthesis of (-)-neplanocin F was achieved in 15 steps from 2,3-O-isopropylidene-D-1,4-ribonolactone. The synthetic methodology can give an access through appropriate modifications to new series of carbanucleosides.
Commentaires: 244OO Times Cited:0 Cited References Count:6
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Revisited 3 '-deoxy-3 '-C-methyl-beta-D-ribonucleoside series
Auteur(s): Aljarah M., Couturier S, Gosselin G., Mathe C., Perigaud C.
(Article) Publié:
Nucleosides Nucleotides & Nucleic Acids, vol. 26 (8-9) p.1125-1128 (2007)
Résumé: The synthesis of some 3'-deoxy-3'-C-methylnucleoside analogues bearing naturally occuring nucleic acid bases was achieved from the preparation of a suitable peracylated 3-deoxy-3-C-methyl sugar using a stereoselective pathway. In addition, examples of chemical modifications at the 2' position are presented.
Commentaires: 2007 1525 7770 English
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L-Nucleoside enantiomers as antivirals drugs: A mini-review
Auteur(s): Mathe C., Gosselin G.
(Article) Publié:
Antiviral Research, vol. 71 p.276-281 (2006)
Résumé: The discovery that some nucleoside analogues endowed with the unnatural L-configuration can possess biological activities has been a significant breakthrough in antiviral chemotherapy. In this regard, lamivudine (3TC) was the first L-nucleoside enantiomer approved against HIV and HBV, and several other L-nucleosides are currently under clinical development as antiviral agents (c) 2006 Elsevier B.V. All rights reserved.
Commentaires: 082IY Times Cited:13 Cited References Count:41
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Synthesis and conformational analysis of C-4 '-modified (2-oxabicyclo-hexyl)pyrimidine nucleosides
Auteur(s): Gagneron J, Gosselin G., Mathe C.
(Article) Publié:
European Journal Of Organic Chemistry, vol. p.4891-4897 (2006)
Résumé: We report on the synthesis of hitherto unknown pyrimidine nucleoside analogues bearing the 2-oxabicyclohexane scaffold (5, 6, 8, 13-17 and 19) with various modifications at the C-4' position including methylene, azido, and arabinolike configuration. Conformational analysis on the nucleoside analogues 6, 14 and 17 indicates that the conformation of such C-4'-modified nucleoside analogues was restricted in the South-East hemisphere of the pseudorotation cycle (between a T-0(1) and a E-2 conformation). ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006).
Commentaires: 103TI Times Cited:3 Cited References Count:34
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