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ULRICH Sébastien
Fonction : Chargé de recherche - HDR
Equipe: IBMM
sebastien.ulrich
enscm.fr
enscm.fr 0467144346
Bureau: P35, Etg: 4 - Site : ENSCM
Distinctions
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Activités de Recherche: |
| Sébastien Ulrich carried out his PhD under the guidance of Pr. Jean-Marie Lehn at ISIS, Strasbourg, France, developing molecular switches for controlling dynamic combinatorial libraries. He subsequently joined the groups of Pr. Harry L. Anderson (Oxford University, UK) as an EPSRC fellow and of Pr. Eric T. Kool (Stanford University, CA, USA) as a Fulbright fellow. In 2011 he was awarded an ANR starting grant and joined the group of Pr. Pascal Dumy, first in Grenoble, then at IBMM in Montpellier, France where he was promoted to a permanent CNRS research position in 2012. He was named Junior Distinguished member of the French Chemical Society in 2014 and was awarded the bronze medal by the CNRS in 2017.
His current research interests lie at the interface of supramolecular chemistry and bioorganic chemistry, and focus in particular on the design and study of dynamic self-assembled systems and multivalent recognition systems for biological applications such as nucleic acids delivery and enzyme inhibition. COLLABORATIONS: Mihail BARBOIU, IEM-Université de Montpellier, France Nadir BETTACHE/Magali GARY-BOBO, IBMM-Université de Montpellier, France Sonia CANTEL, IBMM-Université de Montpellier, France Sébastien CLEMENT, ICGM-Université de Montpellier, Montpellier, France Virginie GERVAIS, IPBS-Plateforme Intégrée de Criblage de Toulouse (PICT), Toulouse, France Larryn PETERSON, Rhodes College, Memphis (TN), USA Françoise SEREIN-SPIRAU/Claude NIEBEL, ICGM-ENSCM, Montpellier, France Artur STEFANKIEWICZ, Adam Mickiewicz University, Poznañ, Poland Mathieu SURIN, Université de Mons, Belgium LIST OF PUBLICATIONS (updated December 2018): 2018 34) Biomolecular Dynamic Covalent Polymers for DNA complexation and siRNA delivery. C. Bouillon, Y. Bessin, F. Poncet, M. Gary-Bobo, P. Dumy, M. Barboiu, N. Bettache, S. Ulrich, J. Mater. Chem. B., 2018, 7239-7246 link 33) Multivalent metallosupramolecular assemblies as effective DNA binding agents. W. Drożdż, A. Walczak, Y. Bessin, V. Gervais, X.‐Y. Cao, J.‐M. Lehn, S. Ulrich, A. R. Stefankiewicz, Chem. Eur. J., 2018, 24, 10802-10811 link 32) Auto-assemblages dynamiques pour la reconnaissance et la vectorisation d’acides nucleiques. S. Ulrich, L’Actualité Chimique, 2018, 430-431, 61-67. link 31) Self-assembly and chiroptical properties in supramolecular complexes of adenosine phosphates and guanidinium-bispyrene. M. Trévisan, M. Fossépré, D. Paolantoni, J. Rubio‐Magnieto, P. Dumy, S. Ulrich, M. Surin, Chirality, 2018, 30 (6), 719-729. link 30) Switching multivalent DNA complexation using metallo-controlled cationic supramolecular self-assemblies. W. Drożdż, Y. Bessin, V. Gervais, X.-Y. Cao, J.-M. Lehn, A. R. Stefankiewicz, S. Ulrich, Chem. Eur. J., 2018, 24 (7), 1518-1521. link 29) Photomodulation of DNA-templated supramolecular assemblies. J. Rubio-Magnieto, T.-A. Phan, M. Fossépré, V. Matot, J. Knoops, T. Jarrosson, P. Dumy, F. Serein-Spirau, C. Niebel, S. Ulrich, M. Surin, Chem. Eur. J., 2018, 24 (3), 706-714. link 2017 28) Generation of Multicomponent Molecular Cages using Simultaneous Dynamic Covalent Reactions. W. Drożdż, C. Bouillon, C. Kotras, S. Richeter, M. Barboiu, S. Clément, A. R. Stefankiewicz, S. Ulrich, Chem. Eur. J., 2017, 23, 18010-18018. link 27) Polyhedral oligomeric silsesquioxane (POSS) bearing glyoxylic aldehyde as clickable platform towards multivalent conjugates. N. Kanfar, A. Mehdi, P. Dumy, S. Ulrich, J.-Y. Winum, Chem. Eur. J., 2017, 23, 17867-17869. link 26) One-Pot Self-Assembly of Peptide-Based Cage-Type Nanostructures using Orthogonal Ligations. E. Bartolami, J. Knoops, Y. Bessin, M. Fossépré, J. Chamieh, P. Dumy, M. Surin, S. Ulrich, Chem. Eur. J., 2017, 23, 14323-14331. link 25) Effective Access to Multivalent Inhibitors of Carbonic Anhydrases Promoted by Peptide Bioconjugation. N. Kanfar, M. Tanc, P. Dumy, C. T. Supuran, S. Ulrich, J.-Y. Winum, Chem. Eur. J., 2017, 23 (28), 6788-6794. link 24) Auto-assemblage dynamique de clusters cationiques pour la complexation et la vectorisation d’acides nucléiques. E. Bartolami, S. Ulrich, P. Dumy, L’Actualité Chimique, 2017, 417. link 2016 23) Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution. C. S. Hwang, L. Xu, W. Wang, S. Ulrich, L. Zhang, J. Chong, J. H. Shin, X. Huang, E. T. Kool, C. E. McKenna, D. Wang, Nucl. Acids Res., 2016, 44 (8), 3820-3828. link 22) Bioactive clusters promoting cell penetration and nucleic acids complexation for drug and gene delivery applications: from designed to self-assembled and responsive systems. E. Bartolami, C. Bouillon, P. Dumy, S. Ulrich, Chem. Commun., 2016, 52, 4257-4273. link 21) A metal-free synthetic approach to peptide-based iminosugar clusters as novel multivalent glycosidase inhibitors. R. Zelli, E. Bartolami, J.-F. Longevial, Y. Bessin, P. Dumy, A. Marra, S. Ulrich, RSC Adv., 2016, 6, 2210-2216. link 2015 20) Emerging trends in enzyme inhibition by multivalent nanoconstructs. N. Kanfar, E. Bartolami, R. Zelli, A. Marra, J.-Y. Winum, S. Ulrich, P. Dumy, Org. Biomol. Chem., 2015, 13, 9894-9906. link 19) Multivalent DNA recognition by self-assembled clusters: deciphering structural effects by fragments screening and evaluation as siRNA vectors. E. Bartolami, Y. Bessin, N. Bettache, M. Gary-Bobo, M. Garcia, P. Dumy, S. Ulrich, Org. Biomol. Chem., 2015, 13, 9427-9438 (themed collection: Multivalent Biomolecular Recognition). link 18) Dynamic expression of DNA complexation with self-assembled biomolecular clusters. E. Bartolami, Y. Bessin, V. Gervais, P. Dumy, S. Ulrich, Angew. Chem. Int. Ed., 2015, 54 (35), 10183-10187. link 17) Fluorescent silica nanoparticles with multivalent inhibitory effects towards carbonic anhydrases. N. Touisni, N. Kanfar, S. Ulrich, P. Dumy, C.T. Supuran, A. Mehdi, J.-Y. Winum, Chem. Eur. J., 2015, 21 (29), 10306-10309. link 16) Synthesis of a-PNA containing a functionalized triazine as nucleobase analogue. E. Bartolami, A. Gilles, P. Dumy, S. Ulrich, Tetrahedron Lett., 2015, 56 (18), 2319-2323. link 15) A Dynamic Combinatorial Approach for Identifying Side Groups that Stabilize DNA-Templated Supramolecular Self-Assemblies. D. Paolantoni, S. Cantel, P. Dumy, S. Ulrich, Int. J. Mol. Sci., 2015, 16, 3609-3625 (special issue "Supramolecular interactions"). link 2014 14) Probing the importance of π-stacking interactions in DNA-templated self-assembly of bisfunctionalized guanidinium compounds. D. Paolantoni, J. Rubio-Magnieto, S. Cantel, J. Martinez, P. Dumy, M. Surin, S. Ulrich, Chem. Commun., 2014, 50, 14257-14260. link 13) Degradable Hybrid Materials Based on Cationic Acylhydrazone Dynamic Covalent Polymers Promote DNA Complexation through Multivalent Interactions. C. Bouillon, D. Paolantoni, J. C. Rote, Y. Bessin, L. W. Peterson, P. Dumy, S. Ulrich, Chem. Eur. J., 2014, 20 (45), 14705-14714. link 12) Probing Secondary Interactions in Biomolecular Recognition by Dynamic Combinatorial Chemistry. S. Ulrich, P. Dumy, Chem. Commun., 2014, 50 (44), 5810-5825 (“Systems chemistry: a web themed issue”). link 11) Theoretical and Structural Analysis of Long C–C Bonds in the Adducts of Polycyanoethylene and Anthracene Derivatives and their Connection to the Reversibility of Diels–Alder Reactions. A. K. H. Hirsch, P. Reutenauer, M. Le Moignan, S. Ulrich, P. J. Boul, J. M. Harrowfield, P. D. Jarowski, J.-M. Lehn, Chem. Eur. J., 2014, 20 (4), 1073-1080. link 10) Oxime Ligation: a Chemoselective Click-Type Reaction for Accessing Multifunctional Biomolecular Constructs. S. Ulrich, D. Boturyn, A. Marra, O. Renaudet, P. Dumy, Chem. Eur. J., 2014, 20 (1), 34-41. link 2013 9) Engineering of biomolecules for sensing and imaging applications. S. Ulrich, P. Dumy, D. Boturyn, O. Renaudet, J. Drug Del. Sci. Tech., 2013, 23 (1), 5-15. link 2012 8) Biodistribution and Pharmacokinetic Studies of a Porphyrin Dimer Photosensitizer (Oxdime) by Fluorescence Imaging and Spectroscopy in Mice Bearing Xenograft Tumors, M. Khurana, S. Ulrich, A. Kim, Y. Moriyama, G. Netchev, M. K. Akens, H. L. Anderson, B. C. Wilson, Photochem. Photobiol., 2012, 88, 1531-1538. link 7) Dissecting Chemical Interactions Governing RNA Polymerase II Transcriptional Fidelity, M. W. Kellinger, S. Ulrich, J. Chong, E. T. Kool, D. Wang, J. Am. Chem. Soc., 2012, 134, 8231-8240. link 2011 6) Importance of Steric Effects on the Efficiency and Fidelity of Transcription by T7 RNA Polymerase, S. Ulrich, E. T. Kool, Biochemistry, 2011, 50 (47), 10343-10349. link 2010 5) Metallo-controlled Dynamic Molecular Tweezers: Design, Synthesis, and Self-assembly by Metal-ion Coordination, S. Ulrich, A. Petitjean, J.-M. Lehn, Eur. J. Inorg. Chem., 2010, 13, 1913-1928. link 2009 4) Adaptation and Optical Signal Generation in a Constitutional Dynamic Network, S. Ulrich, J.-M. Lehn, Chem. Eur. J., 2009, 15, 5640-5645. link 3) Adaptation to Shape Switching by Component Selection in a Constitutional Dynamic System, S. Ulrich, J.-M. Lehn, J. Am. Chem. Soc., 2009, 131, 5546-5559. link 2) Reversible Constitutional Switching between Macrocycles and Polymers Induced by Shape Change in a Dynamic Covalent System, S. Ulrich, E. Buhler, J.-M. Lehn, New. J. Chem., 2009, 33, 271-292. link 2008 1) Reversible Switching between Macrocyclic and Polymeric States by Morphological Control in a Constitutional Dynamic System, S. Ulrich, J.-M. Lehn, Angew. Chem. Int. Ed., 2008, 47, 2240-2243. link |
Domaines de Recherche:
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Productions scientifiques :
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Photomodulation of DNA-Templated Supramolecular Assemblies 
Auteur(s): Rubio-Magnieto Jenifer, Phan Tuan-Anh, Fossépré Mathieu, Matot Valérie, Knoops Jeremie, Jarrosson Thibaut, Dumy P., Serein-Spirau Françoise, Niebel Claude, Ulrich S. (Article) Publié: Chemistry - A European Journal, vol. 24 p.706-714 (2018) |
, Surin Mathieu|
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Generation of Multicomponent Molecular Cages using Simultaneous Dynamic Covalent Reactions Auteur(s): Drożdż Wojciech, Bouillon C., Clément Clément, Richeter Sébastien, Barboiu Mihail, Clément Sébastien, Stefankiewicz Artur R., Ulrich S. (Article) Publié: Chemistry - A European Journal, vol. 23 p.18010 - 18018 (2017) |
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Oxime Ligation: A Chemoselective Click-Type Reaction for Accessing Multifunctional Biomolecular Constructs Auteur(s): Ulrich S., Boturyn Didier, Marra A., Renaudet Olivier, Dumy P. (Article) Publié: Chemistry - A European Journal, vol. 20 p.34 - 41 (2014) |