Diastereospecific synthesis of new 4-substituted L-theanine derivatives. Auteur(s): Rolland-Fulcrand V. (Article) Publié: Tetrahedron Asymmetry, vol. 25 p.690-696 (2014) Ref HAL: hal-00992964_v1 DOI: 10.1016/j.tetasy.2014.03.016 Résumé: Considering the biological activity of L-theanine as a potent agonist of NMDA receptors, impacting on glutamatergic synapse activity, we have developed an asymmetric synthesis of new enantiomerically pure 4-substituted L-theanine derivatives. The key step is a stereospecific alkylation on a previously synthesized and correctly protected (S)-pyroglutamate. |