|Diastereospecific synthesis of new 4-substituted L-theanine derivatives. |
Auteur(s): Rolland-Fulcrand V.
(Article) Publié: Tetrahedron Asymmetry, vol. 25 p.690-696 (2014)
Ref HAL: hal-00992964_v1
Considering the biological activity of L-theanine as a potent agonist of NMDA receptors, impacting on glutamatergic synapse activity, we have developed an asymmetric synthesis of new enantiomerically pure 4-substituted L-theanine derivatives. The key step is a stereospecific alkylation on a previously synthesized and correctly protected (S)-pyroglutamate.