- Diastereospecific synthesis of new 4-substituted L-theanine derivatives. doi link

Auteur(s): Rolland-Fulcrand V.

(Article) Publié: Tetrahedron Asymmetry, vol. 25 p.690-696 (2014)

Ref HAL: hal-00992964_v1
DOI: 10.1016/j.tetasy.2014.03.016

Considering the biological activity of L-theanine as a potent agonist of NMDA receptors, impacting on glutamatergic synapse activity, we have developed an asymmetric synthesis of new enantiomerically pure 4-substituted L-theanine derivatives. The key step is a stereospecific alkylation on a previously synthesized and correctly protected (S)-pyroglutamate.