|Cone snail venomics: from novel biology to novel therapeutics. |
Auteur(s): Prashanth Jutty Rajan, Brust Andreas, Ai-Hua Jin, Alewood Paul F, Dutertre S., Lewis Richard J
(Article) Publié: Future Medicinal Chemistry, vol. 6 p.1659-1675 (2014)
Ref HAL: hal-01089383_v1
Peptide neurotoxins from cone snails called conotoxins are renowned for their therapeutic potential to treat pain and several neurodegenerative diseases . Inefficient assay-guided discovery methods have been replaced by high-throughput bioassaysintegrated with advanced MS and next-generation sequencing, ushering in the era of ‘venomics’. In this review, we focus on the impact of venomics on the understanding of cone snail biology as well as the application of venomics to accelerate the discovery of new conotoxins. We also discuss the continued importance of medicinal chemistry approaches to optimize conotoxins for clinical use, with a descriptive case study of MrIA featured.