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- Photomodulation of DNA-Templated Supramolecular Assemblies doi link

Auteur(s): Rubio-Magnieto Jenifer, Phan Tuan-Anh, Fossépré Mathieu, Matot Valérie, Knoops Jeremie, Jarrosson Thibaut, Dumy P., Serein-Spirau Françoise, Niebel Claude, Ulrich S.(Corresp.), Surin Mathieu

(Article) Publié: Chemistry - A European Journal, vol. 24 p.706-714 (2018)


Ref HAL: hal-01666843_v1
DOI: 10.1002/chem.201704538
Résumé:

Anew type of DNA ligand that contains a phosphate-binding group and a photoresponsive azobenzene moiety is reported. When the azobenzene is in trans configuration, the ligand binds to the minor groove of a double-stranded DNA, whereas it partially desorbs upon trans –cis isomerisation with light.The ability to photoswitch the ligand upon interaction with DNA is evidenced by (chir)optical signatures, and deciphered by the differences of binding geometry, stability, and dynamics of the DNA/ligand complexes for the two isomers. We exploit these properties to photomodulate DNA-templated self-assembly, through the incorporation of another pi-stacking DNA ligand, which together with the photoresponsive ligand form mixed supramolecular complexes along DNA. Our study demonstrates that well-designed photoresponsive DNA binders can be used to modulate multicomponent supramolecular DNA assemblies.