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Enzyme inhibitors and substrates.
Alzheimer’s disease: proteases involved in the production of b-amyloid peptide. Malaria: SUB-2, Plasmodium protease involved in the invasion of erythrocytes by (...)
The research activity in the DSBC group is mainly involved in physical organic chemistry and analytical chemistry, mostly of α-amino acids, (poly)peptides and their derivatives. We are especially interested in both (i) a physico-chemical approach of the reactivity of biomolecules and/or their precursors or derivatives, and (ii) the development of innovating separative science methodologies applying to polymers. DSBC research topics are organised according to four major directions.
Glycochemistry and Molecular Recognition team: Synthesis of carbohydrate analogues and oligosaccharides Development of templates (molecules and nanoparticles) for multivalent presentation (...)
Team 3 : Nucleosides & Phosphorylated Effectors
Summary The research area of the « Nucleosides & Phosphorylated Effectors » team, is clearly at the frontier of the chemistry and the (...)
see new website : http://ibmmpolymerbiomaterials.com
1. Research axes
M. CALMES
Methodologies in asymmetric synthesis. Chiral auxiliaries. Solution and solid-phase synthesis. -aminoacids. Constrained amino acids and derivatives. Oligomers.
F. (...)
1. Research axes
Total synthesis of bioactive lipids, photoaffine probes (endocannabinoid analogues) and isoprostane analogues (Isoprostanes, Neuroprostanes or Phytoprostanes) or Isofuranes (...)