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Chemistry

Chemistry of Amino Acids, Peptides, Heterocycles, Supported Chemistry

Enzyme inhibitors and substrates.
Alzheimer’s disease: proteases involved in the production of b-amyloid peptide.
Malaria: SUB-2, Plasmodium protease involved in the invasion of erythrocytes (...)

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Dynamics of Complex Biomolecular Systems

The research activity in the DSBC group is mainly involved in physical organic chemistry and analytical chemistry, mostly of α-amino acids, (poly)peptides and their derivatives. We are especially interested in both (i) a physico-chemical approach of the reactivity of biomolecules and/or their precursors or derivatives, and (ii) the development of innovating separative science methodologies applying to polymers. DSBC research topics are organised according to four major directions.

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Glycochemistry and Molecular Recognition

Glycochemistry and Molecular Recognition team: Synthesis of carbohydrate analogues and oligosaccharides Development of templates (molecules and nanoparticles) for multivalent presentation (...)

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Modified Oligonucleotides

The research done by the team led by J.-J. Vasseur is listed under the theme “Nucleic Acids: from their role as targets to the therapeutic and diagnostic potential of their constituents and (...)

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Nucleosides & Phosphorylated Effectors

Team 3 : Nucleosides & Phosphorylated Effectors
Summary The research area of the « Nucleosides & Phosphorylated Effectors » team, is clearly at the frontier of the chemistry and the (...)

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Polymer for Health and Biomaterials Department

see new website : http://ibmmpolymerbiomaterials.com

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Stereoselective syntheses & modified amino acids

1. Research axes
M. CALMES
Methodologies in asymmetric synthesis. Chiral auxiliaries. Solution and solid-phase synthesis. -aminoacids. Constrained amino acids and derivatives. Oligomers. (...)

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Total Synthesis of Bioactive Lipids

1. Research axes
Total synthesis of bioactive lipids, photoaffine probes (endocannabinoid analogues) and isoprostane analogues (Isoprostanes, Neuroprostanes or Phytoprostanes) or Isofuranes (...)

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