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Download the New Computer Program to facilitate the Identification of modified PEG’s by Mass Spectrometry.

by florent_r0s1 - published on

Download the New Computer Program to facilitate the Identification of modified PEG's by Mass Spectrometry.

Chemists from the Department of Aminoacids, Peptides and Proteins of the IBMM have developed a computer program to facilitate the identification of modified PEG’s by Mass Spectrometry. Resulting from a collaborative work between Dr Frédéric Lamaty (IBMM, team 7) & Prof. Christine Enjalbal (IBMM, team 9), the program CALCPEG uses data generated by Mass Spectrometry (MALDI or ESI) to confirm the modification of the end group(s) of a PEG of any size. This method may find applications in research areas involving the synthesis, modification, conjugation, degradation… of PEG’s. The program CALCPEG is now available for download, for PC or Mac computers, in French or in English from the IBMM website.

Link to original research articles :

1. Enjalbal, C.; Ribière , P.; Lamaty, F.; Yadav-Bhatnagar, N.; Martinez, J.; Aubagnac, J.-L. MALDI-TOF MS Analysis of Soluble PEG Based Multi-Step Synthetic Reaction Mixtures with Automated Detection of Reaction Failure J. Am. Soc. Mass Spec. 2005, 16, 670-678 DOI : 10.1021/ac0203701

2. Enjalbal, C.; Lamaty, F.; Sanchez, P.; Suberchicot, E.; Ribière, P.; Varray, S.; Lazaro, R.; Yadav-Bhatnagar, N.; Martinez, J.; Aubagnac, J.-L. Characterization of Soluble Polymer Supported Organic Compounds by LC/Electrospray Ionization MS : Toward a Complete Automation of the Liquid-Phase Process in Combinatorial Chemistry. Anal. Chem. 2003, 75, 175-184. DOI : 10.1016/j.jasms.2005.01.020

View online : Link to download the application :