Offre de Post-Doc : Synthesis of phosphorus-based matrices for mapping Hg species and their interaction with biomolecules in fish tissues
Post-doctoral position
Synthesis of phosphorus-based matrices for mapping Hg species and their interaction with biomolecules in fish tissues
- Duration 18 months (from january/february 2026 to july 2027).
- Funding Agence nationale de la Recherche (ANR) – salary according to Montpellier University remuneration.
- Candidate profile PhD in organic chemistry from less than 3 years.
- Application deadline15th october 2025.
Description of the project
The direct detection of MeHg accumulated in biological tissues, binding randomly to the amino and sulfhydryl groups of DNA and peptides such as glutathione is a challenge in MALDI-MSI. As conventional matrices may not be appropriated because Hg species integrity could be lost during sample preparation, in the frame of the ANR project MOONFISH, we propose to explore new phosphorus-based matrices for the detection of MeHg derivatives in tissues. A variety of aromatic organophosphorus compounds bearing stable thiophosphoryl groups, built on previous synthesis developed by the research team in Montpellier, to improve the detection of Hg species from the analyte, with a better resolution and sensitivity.
Keywords: Multi-step organic synthesis – Phosphorus chemistry – Phospholes – MALDI matrices – organometallics
Candidate profile
The candidate must have a Ph.D. in organic or medicinal chemistry and excellent skills in synthesis, purification and characterization of products (NMR, LCMS, MALDI-TOF). Research experience in MALDI-TOF mass spectrometry may be a valuable asset but not mandatory. We are looking for candidates highly motivated by scientific challenges and with a proactive attitude towards problem solving. The ability to work in a multidisciplinary research team, as well as effective communication and writing skills with a good mastery of the English language are essential for a successful selection.
Context
The recruited candidate will join the team « ChemBioNAC » led by Pr Michael Smietana at IBMM (Institute of biomolecules Max Mousseron, Nucleic Acids Department), located in the Pôle Chimie Balard in Montpellier. The project will be carried out in collaboration with Dr. Sandra Mounicou (IPREM, Pau) whose research focus on the understanding of trace elements (metals, metalloids, halogens, lanthanides) laying mechanisms of toxicity or essentiality in living organisms.
Application procedure
Candidates must submit a cover letter, CV and recommendation letter(s) to