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Hervé CottetProfessor in Analytical Chemistry
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Electrokinetic separation techniques
Taylor Dispersion Analysis (…want to know more about TDA? see there)Study of biomolecule interactions (stoichiometry, affinity constants)
Characterization of proteins, biopolymers, polyelectrolytes and nanoparticles
Characterization of vaccines, antigens and mRNA LNPElectrophoretic mobility modelling
Capillary coatings for protein analysis in CE and CE-MS
Dendrigraft Poly-L-lysine
Industrial and academic programs
SCIEX Microscale Separations Innovation Medal Award, 2024. (read more…)
Awardee 2016 of the French Scholar Series (Peter Wall Institute for Advanced Studies and Frenh Consulate Vancouver)
Junior Member of the Institut Universitaire de France (IUF), 2011–2016. (read more…)
Award “Chercheur d’Avenir”, Région Languedoc-Roussillon, 2010–2013.
Award from the French Chemical Society (Analytical Chemistry Division), 2006.
Lauréat ACI jeunes chercheurs (French National Research Agency), 2004–2008.
P162. Adjusting the electroosmotic flow for CE separation of proteins by using mixed polycations/polyzwitterions poly(α-L-lysine)-based multilayer coatings. H. Frick, L. Dhellemmes, A. Höchsmann, L. Leclercq, C. Neusüß, H. Cottet, N. Schaschke, Polym. Chem., 2025, submitted.
P161. Ultra-high separation of intact proteins and proteoforms by CZE-MS using sulfobetaine-modified poly(α-L-lysine)-based multilayer coatings for EOF adjustment. A. Höchsmann, H. Frick, L. Dhellemmes, L. Leclercq, H. Cottet, N. Schaschke, C. Neusüß, Proteomics, 2025, submitted.
P160. Interaction study between gadolinium-based contrast agents and lysozyme using frontal analysis continuous capillary electrophoresis. C. Somnin, J. Chamieh, L. Leclercq, C. Medina, O. Rousseaux, H. Cottet, Anal. Chim. Acta, 2025, under revision.
P159. Surfactant-based coatings for protein separation by capillary electrophoresis – A review. C. Prakobdi, L. Dhellemmes, L. Leclercq, G. Rydzek, H. Cottet, Anal. Chim. Acta, 2025, 1356, 343945.
P158. Study of interactions between gadolinium-based contrast agents and collagen by Taylor dispersion analysis and frontal analysis continuous capillary electrophoresis. C. Somnin, J. Chamieh, L. Leclercq, C. Medina, O. Rousseaux, H. Cottet, Pharmaceuticals, 2024, 17(12), 1633.
P157. Optical determination of the internal capillary diameter used in Taylor dispersion analysis. S. Roca, L. Leclercq, P. Gonzalez, C. Somnin, M. Garrido Álvarez, L. Dhellemmes, J. Chamieh, H. Cottet, Electrophoresis, 2024, Early view. DOI: 10.1002/elps.202400156
P156. Preventing the impact of solute adsorption in Taylor dispersion analysis: application to protein and lipid nanoparticle analysis. S. Roca, L. Leclercq, J.-P. Biron, M. Martin, H. Cottet, J. Chromatogr. A, 2024, 1736, 465325.
P155. Getting the best out of capillary electrophoresis and capillary electrophoresis–mass spectrometry by quantifying sources of peak broadening for proteins using polyelectrolyte multilayer coated fused silica capillaries. L. Dhellemmes, L. Leclercq, A. Höchsmann, C. Neusüß, M. Martin, H. Cottet, Anal. Chem., 2024, 96(38), 15205–15212.
P154. Charge variant analysis of monoclonal antibodies by CZE-MS using a successive multiple ionic-polymer layer coating based on diethylaminoethyl-dextran. A. Höchsmann, L. Dhellemmes, L. Leclercq, H. Cottet, C. Neusüß, Electrophoresis, 2025, 45(5–6), 279–289.
P153. Dual contributions of analyte adsorption and electroosmotic inhomogeneity to separation efficiency in capillary electrophoresis of proteins. L. Dhellemmes, L. Leclercq, L. Lichtenauer, A. Höchsmann, M. Leitner, A. Ebner, M. Martin, C. Neusüß, H. Cottet, Anal. Chem., 2024, 96(28), 11172–11180.
P152. Taylor dispersion analysis for measurement of diffusivity and size of gadolinium-based contrast agents. C. Somnin, L. Leclercq, J. Chamieh, M. Le Menedeu, C. Medina, O. Rousseaux, R. Tripier, C. Platas Iglesias, H. Cottet, Eur. J. Pharm. Sci., 2024, 200, 106831.
P151. Investigating cationic and zwitterionic successive multiple ionic-polymer layers for protein separation by capillary electrophoresis. L. Dhellemmes, L. Leclercq, H. Frick, A. Höchsmann, N. Schaschke, C. Neusüß, H. Cottet, J. Chromatogr. A, 2024, 1720, 464802.
P150. Taylor dispersion analysis using capacitively coupled contactless conductivity detector. C. Somnin, J. Chamieh, P. Saetear, H. Cottet, Talanta, 2024, 272, 125815.
P149. Size-based characterization of dendrigraft poly(L-lysine) by free solution capillary electrophoresis using polyelectrolyte multilayer coatings. S. Roca, L. Leclercq, H. Cottet, J. Chromatogr. A, 2024, 1718, 464719.
P148. Self-emulsifying drug delivery systems (SEDDS): how organic solvent release governs the fate of their cargo. A. M. Jörgensen, R. Wibel, F. Veider, B. Hoyer, J. Chamieh, H. Cottet, A. Bernkop-Schnürch, Int. J. Pharm., 2023, 647, 123534.
P147. Fast, simple and calibration-free size characterization and quality control of extracellular vesicles using capillary Taylor dispersion analysis. S. Obeid, J. Chamieh, T. D. Mai, M. Morani, M. Reyre, Z. Krupova, P. Defrenaix, H. Cottet, M. Taverna, J. Chromatogr. A, 2023, 1705, 464189.
P146. Optimization of limit of detection in Taylor dispersion analysis: application to the size determination of vaccine antigens. C. Malburet, M. Martin, L. Leclercq, J.-F. Cotte, J. Thiébaud, J.-P. Biron, J. Chamieh, H. Cottet, Talanta Open, 2023, 7, 100209.
P145. Critical parameters for highly efficient and reproducible polyelectrolyte multilayer coatings for protein separation by capillary electrophoresis. L. Dhellemmes, L. Leclercq, A. Höchsmann, C. Neusüß, J.-P. Biron, S. Roca, H. Cottet, J. Chromatogr. A, 2023, 1695, 463912.
P144. Modifying last layer in polyelectrolyte multilayer coatings for capillary electrophoresis of proteins. S. Roca, L. Leclercq, P. Gonzalez, L. Dhellemmes, L. Boiteau, G. Rydzek, H. Cottet, J. Chromatogr. A, 2023, 1692, 463837.
P143. Molecular determinants of fibrillation in a viral amyloidogenic domain from combined biochemical and biophysical studies. J. F. Nilsson, F. Gondelaud, H. Baroudi, G. Pesce, C. Bignon, D. Ptchelkine, J. Chamieh, H. Cottet, A. V. Kajava, S. Longhi, Int. J. Mol. Sci. 2023, 24(1), 399.
P142. Taylor dispersion analysis discloses the impairment of Aβ peptide aggregation by the presence of a fluorescent tag. M. Deleanu, J.-F. Hernandez, H. Cottet, J. Chamieh, Electrophoresis, 2023, 44(7–8), 701–710.
P141. Taylor dispersion analysis to support lipid-nanoparticle formulations for mRNA vaccines. C. Malburet, L. Leclercq, J.-F. Cotte, J. Thiébaud, E. Bazin, M. Garinot, H. Cottet, Gene Ther., 2023, 30(5), 421–428.
Last update: May 12, 2025.
Taylor dispersion analysis, capillary electrophoresis, polyelectrolyte complexes, characterization of polymers, nanoparticles, dendrigraft polymers, dendrimers, analysis of bacteria; analysis of polymers, drug delivery systems. Expertise en électrophorèse capillaire. Consultance en électrophorèse capillaire. Expertise and consultancy in capillary electrophoresis and Taylor dispersion analysis.
ORCiD: 0000-0002-6876-175X