photo H. Cottet 2020

Hervé Cottet

Professor in Analytical Chemistry
University of Montpellier

Institut des Biomolécules Max Mousseron
UMR 5247, Université de Montpellier, CNRS, ENSCM

CNRS Pôle Chimie Balard Recherche
1919 route de Mende
F-34293 Montpellier cedex 5, France

Phone : +33 (0) 4 48 79 21 96
E-mail :


Research Interests

Electrokinetic separation techniques
Taylor Dispersion Analysis

Study of biomolecule interactions (stoichiometry, affinity constants)
Chemical reactivity of aminoacid N-carboxyanhydrides (NCA)
Characterization of proteins, polyelectrolytes, biopolymers, nanoparticles and colloids

Electrophoretic mobility modelling
Capillary coatings (SMIL) for protein analysis in CE and CE-MS
Dendrigraft Poly-L-lysine

ORCiD iconORCiD: 0000-0002-6876-175X

Curriculum Vitae




Industrial and academic programs




Recent papers (2019-2022): complete list here

P141. Taylor dispersion analysis to support LNP formulations for mRNA vaccines. C. Malburet, L. Leclercq, J.-F. Cotte, J. Thiébaud, E. Bazin, M. Garinot, H. Cottet. Gene Therap. 2022, accepted.

P140. Polyelectrolyte multilayers in capillary electrophoresis. S. Roca, L. Dhellemmes, L. Leclercq, H. Cottet. ChemPlusChem 2022, 87(4), e202200028.

P139. Determination of ultrahigh molar mass of polyelectrolytes by Taylor dispersion analysis. X. Leclercq, L. Leclercq, A. Guillard, L. Rodriguez, O. Braun, C. Favero, H. Cottet. J. Chromatogr. A, 2022, 1670, 462949.

P138. Taylor dispersion analysis and atomic force microscopy provide quantitative insight on the aggregation kinetics of Aβ(1-40)/Aβ(1-42) amyloid peptide mixtures. M. Deleanu, O. Deschaume, J.-F. Hernandez, L. Cipelletti, C. Bartic, H. Cottet, J. Chamieh, ACS Chem. Neurosci., 2022, 13(6), 786–795.

P137. Size and charge characterization of lipid nanoparticles for mRNA vaccines. C. Malburet, L. Leclercq, J.-F. Cotte, J. Thiébaud, E. Bazin, M. Garinot, H. Cottet, Anal. Chem., 2022, 94(11), 4677–4685.

P136. Separation of three strains of polio virus by capillary zone electrophoresis and study of their interaction with aluminum oxyhydroxide. C. Malburet, L. Leclercq, J.-F. Cotte, J. Thiébaud, H. Cottet, J. Chromatogr. A, 2022, 1667, 462838.

P135. Generation and characterization of air micro-bubbles in highly hydrophobic capillaries. C. Renard, L. Leclercq, H. Cottet, Electrophoresis, 2022, 43(5–6), 767–775.

P134. Chemoprevention with a tea from Hawthorn (Crataegus oxyacantha) leaves and flowers attenuates colitis in rats by reducing inflammation and oxidative stress. R. de Paula do Nascimento, A. P. da Fonseca Machado, V. Silva Lima, A. M. Tomazini Munhoz Moya, L. M. Reguengo, S. Bogusz Jr, R. Franco Leal, P. Cao-Ngọc; J.-C. Rossi, L. Leclercq, H. Cottet, C. Baú Betim Cazarin, M. R. Maróstica Jr, Food Chem. X, 2021, 12, 100139.

P133. Biodegradation of metal-based ultra-small nanoparticles: a combined approached using TDA-ICP-MS and CE-ICP-MS. L. Labied, P. Rocchi, T. Doussineau, J. Randon, O. Tillement, H. Cottet, F. Lux, A. Hagège, Anal. Chim. Acta, 2021, 1185, 339081.

P132. Unraveling the speciation of β-amyloid peptides during the aggregation process by Taylor dispersion analysis. M. Deleanu, J.-F. Hernandez, L. Cipelletti, J.-P. Biron, E. Rossi, M. Taverna, H. Cottet, J. Chamieh, Anal. Chem., 2021, 93, 6523–6533.

P131. Antigen-adjuvant interactions in vaccines by Taylor dispersion analysis: size characterization and binding parameters. C. Malburet, L. Leclercq, J. F. Cotte, J. Thiebaud, S. Marco, M. C. Nicolaï, H. Cottet, Anal. Chem., 2021, 93, 6508–6515.

P130. Screening for pancreatic lipase natural modulators by capillary electrophoresis hyphenated to spectrophotometric and conductometric dual detection. G. Al Hamoui Dit Banni, R. Nasreddine, S. Fayad, P. Cao-Ngoc, J.-C. Rossi, L. Leclercq, H. Cottet, A. Marchal, R. Nehmé, Analyst, 2021, 146, 1386–1401.

P129. Water-based extraction of Bioactive Principles from Blackcurrant leaves and Chrysanthellum americanum: a comparative study. P. Cao-Ngoc, L. Leclercq, J.-C. Rossi, J. Hertzog, A.-S. Tixier, F. Chemat, R. Nasreddine, G. Al Hamoui Dit Banni, R. Nehmé, P. Schmitt-Kopplin, H. Cottet. Foods, 2020, 9, 1478.

P128. Characterization of ultrahigh molar mass polyelectrolytes by capillary electrophoresis. X. Leclercq, L. Leclercq, A. Guillard, L. Rodriguez, O. Braun, C. Favero, H. Cottet. J. Chromatogr. A, 2020, 461536.

P127. Study of interactions between antigens and polymeric adjuvants in vaccines by frontal analysis continuous capillary electrophoresis. C. Malburet, L. Leclercq, J.-F. Cotte, J. Thiebaud, H. Cottet. Biomacromolecules, 2020, 21, 8, 3364–3373.

P126. Co-solvents in self-emulsifying drug delivery systems (SEDDS) – do they really solve our solubility problems? A. Jörgensen, J. Friedl, R. Wibel, J. Chamieh, H. Cottet, A. Bernkop-Schnürch, Mol. Pharmaceut., 2020, 17, 9, 3236–3245.

P125. Capillary Zone Electrophoresis-Top-Down Tandem Mass Spectrometry for in-depth Characterization of Hemoglobin Proteoforms in Clinical and Veterinary Samples. A. Stolz, Y. Hedeland, L. Salzer, J. Römer, R. Heiene, L. Leclercq, H. Cottet, J. Bergquist, C. Neusüß, Anal. Chem., 2020, 92, 15, 10531–10539.

P124. Quantification of adsorption and optimization of separation of proteins in Capillary Electrophoresis. L. Leclercq, C. Renard, M. Martin, H. Cottet. Anal. Chem., 2020, 92, 15, 10743–10750.

P123. Mass transfer efficiency in rare earths extraction using a hollow fiber pertraction device. M. Toure, J. Chamieh, G. Arrachart, S. Pellet-Rostaing, H. Cottet, J. Duhamet, Separation and Purification Technology, 2020, 251, 117330.

P122. Characterization of diblock copolymers by capillary electrophoresis: From electrophoretic mobility distribution to distribution of composition. A. Phimphachanh, J. Chamieh, L. Leclercq, J. Pinaud, S. Harrisson, M. Destarac, P. Lacroix-Desmazes, C. Gérardin, M. In, H. Cottet, Macromolecules, 2020, 53, 334–345.

P121. Optimizing Water-based Extraction of Bioactive Principles of Hawthorn: from Experimental Laboratory Research to Homemade Preparations. P. Cao Ngoc, L. Leclercq, J.-C. Rossi, I. Desvignes, J. Hertzog, A.-S. Tixier, F. Chemat, P. Schmitt-Kopplin, H. Cottet, Molecules, 2019, 24, 4420.

P120. Superhydrophobic capillary coatings: elaboration, characterization and application to electrophoretic separations. C. Renard, L. Leclercq, A. Stocco, H. Cottet, J. Chromatogr. A, 2019, 1603, 361–370.

P119. Size-based characterization of polysaccharides by Taylor Dispersion Analysis with photochemical oxidation or back scattering interferometry detections. L. Leclercq, P. Saetear, A. Rolland-Sabaté, J.-P. Biron, J. Chamieh, L. Cipelletti, D. J. Bornhop, H. Cottet, Macromolecules, 2019, 52, 4421–4431.

P118. Characterization of hydrosoluble fraction and oligomers in poly(vinylidene chloride) latexes by capillary electrophoresis using electrophoretic mobility modeling. A. Ibrahim, H. Cottet, J. Chromatogr. A., 2019, 1598, 223–231.

P117. Supramolecular self-assembly of DNA with a cationic polythiophene – From polyplexes to fibers. M. Leclercq, J. Rubio-Magnieto, D. Mohammed, S. Gabriele, L. Leclercq, H. Cottet, S. Richeter, S. Clément, M. Surin, ChemNanoMat, 2019, 5, 703–709.

P116. Peptide release from SEDDS containing hydrophobic ion pair therapeutic peptides measured by Taylor dispersion analysis. J. Chamieh, A. Domènech Tarrat, C. Doudou, V. Jannin, F. Demarne, H. Cottet, Int. J. Pharm., 2019, 559, 228–234.

P115. Modulation of the electroosmotic mobility using polyelectrolyte multilayer coatings for protein analysis by capillary electrophoresis. L. Leclercq, M. Morvan, J. Koch, C. Neusuess, H. Cottet, Analytica Chimica Acta, 2019, 1057, 152–161.



    Junior Member of the Institut Universitaire de France (IUF), 2011–2016.

    Awardee 2016 of the French Scholar Series (Peter Wall Institute for Advanced Studies and Frenh Consulate Vancouver)

    Award “Chercheur d’Avenir”, Région Languedoc-Roussillon, 2010–2013.

    Award from the French Chemical Society (Analytical Chemistry Division), 2006.

    Lauréat ACI jeunes chercheurs (French National Research Agency), 2004–2008.


Last update: July 10, 2022.

Taylor dispersion analysis, capillary electrophoresis, polyelectrolyte complexes, characterization of polymers, nanoparticles, dendrigraft polymers, dendrimers, analysis of bacteria; analysis of polymers, drug delivery systems. Expertise en électrophorèse capillaire. Consultance en électrophorèse capillaire. Expertise and consultancy in capillary electrophoresis and Taylor dispersion analysis.