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Enamine-based organic reducers – from the tool to the applications

Séminaire Chimie ED459

Dr. Julie Broggi, MCF (ICR Institut de Chimie Radicalaire, UMR 7273, CNRS, Aix-Marseille-Université)

Le Jeudi 07 décembre 2023 à 14h

CNRS, Salle Balard 1 (bâtiment Balard RdC, 1919 route de Mende)

Date de début : 2023-12-07 14:00:00

Date de fin : 2023-12-07 15:30:00

Lieu : CNRS salle Balard-1 (site RdM bât. Balard RdC)

Intervenant : Dr. Julie Broggi, MCF

ICR Institut de Chimie Radicalaire, UMR 7273, CNRS, Aix-Marseille-Université

(reprogrammation du séminaire annulé le 6 avril en raison d’une grève des transports ayant empêché la conférencière de venir à Montpellier)

Enamine-based organic electron donors (OEDs) are powerful reducing agents recognized for their potential in the reduction of challenging substrates.[1] They are capable of single- or double-electron transfers to organic substrates under mild and homogeneous conditions, promoting bond formations through the generation of radical or anionic intermediates. They thus emerge as an attractive novel source of reducing electrons.

Our research focus on synthesizing new organic electron donors and establishing their fields of applications. The pharmacomodulations of compounds of therapeutic interests, the valorization of greenhouse gases or the preparation of high value-added polymers are some examples that will be presented.[2,3]

Scheme: see illustration in attached PDF abstract.


1. For reviews, see: a) J. Broggi, T. Terme, P. Vanelle, Angew. Chem. Int. Ed. 2014, 53, 384–413; b) J. A. Murphy, J. Org. Chem. 2014, 79, 3731–3746; c) E. Doni, J. A. Murphy, Chem. Commun. 2014, 50, 6073–6087.

2. a) G. Tintori, P. Nabokoff, R. Buhaibeh, D. Bergé-Lefranc, S. Redon, J. Broggi, P. Vanelle, Angew. Chem. Int. Ed. 2018, 57, 3148–3153; b) A. Taponard, T. Jarrosson, L. Khrouz, M. Médebielle, J. Broggi, A. Tlili, Angew. Chem. Int. Ed. 2022, 61, e202204623; c) M. Roche, C. Lacroix, O. Khoumeri, D. Franco, J. Neyts, T. Terme, P. Leyssen, P. Vanelle, Eur. J. Med. Chem. 2014, 76, 445–459.

3. a) J. Broggi, M. Rollet, J. -L. Clément, G. Canard, T. Terme, D. Gigmes, P. Vanelle, Angew. Chem. Int. Ed. 2016, 55, 5994–5999; b) Y. Zhao, M. Rollet, L. Charles, G. Canard, D. Gigmes, P. Vanelle, J. Broggi, Angew. Chem. Int. Ed. 2021, 60, 19389–19396.

Contact local IBMM : Dr. Xavier Bantreil (GreenChem group)

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