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A publication by the IBMM Green Chemistry team together with PolyPeptide Group and the IBMM peptide team made it to the cover of the journal ChemistryEurope from Wiley Chemistry Europe.


This work is dedicated to Prof. Jean Martinez, at the occasion of his 75th birthday, a strong supporter and active collaborator of the IBMM GreenChem team.

We reported in this publication how applications of screw-generated mechanical forces to a mixture of amino acids and coupling agents, delivered to the top of a TSE barrel promoted the synthesis of the corresponding peptide—in this case, aspartame—recovered from the die of the TSE. Various peptides were synthesized by this flow mechanochemistry method. The artwork was designed by Marcelin Lamaty.