SYNTHESIS OF AFFINITY PROBES TO DECIPHER THE MODE OF ACTION OF ANS RECEPTOR ANTAGONIST Context and objective of the project In the context of liver cancer, despite existing treatment most patients remain at high risk due to resistance development to tyrosine kinase inhibitors (TKIs). It was discovered an indole-ethanamine compound, targeting ANS receptors, has synergistic […]
Oleacein, a bioactive compound of olive oil and olive mill wastewater, has one of the strongest antioxidant activities among olive phenolics. However, few reports explore the in vivo antioxidant activity of oleacein, with no clear identification of the biological pathway involved. Earlier studies have demonstrated a link between stress resistance, such as oxidative stress, and […]
Mechano-Activation of Molecular Nitrogen for Ammonia Synthesis Ammonia (NH3) is the second most mass-produced molecule (180 MT/year) and a major intermediate for the production of chemicals and fertilizers. There is also an increasing interest on ammonia as a carbon-free fuel, and even as a hydrogen vector due to its physical properties. Despite its many […]
This work is dedicated to Prof. Jean Martinez, at the occasion of his 75th birthday, a strong supporter and active collaborator of the IBMM GreenChem team. We reported in this publication how applications of screw-generated mechanical forces to a mixture of amino acids and coupling agents, delivered to the top of a TSE barrel […]
The team Green Chemistry and Enabling Technologies published new results on the mechanochemical synthesis of NO-releasing drugs. These drugs belong to the family of iminosydnones and their biological activity arises from the release of NO. This high reactivity can make their synthesis and isolation very challenging. And mechanochemistry comes to the rescue with facilitated solvent-free […]
To read the aertiche : https://www.cnrsinnovation.com/actualite/la-start-up-womed-soigne-linfertilite-des-femmes/
PROTACs-PI3Kγ open a new pathway for targeted treatment of acute myeloid leukemia (AML) Acute myeloid leukemia (AML) is the most common leukemia in adults. Recent medical advances have achieved up to 50% 5-year survival rates. However, this rate still needs improvement, especially for individuals aged 60 and over, whose 5-year survival rate is only 10%, […]
Wednesday June 26Th at 10 am Prof. Sébastien Papot will give a seminar entitled « Comprendre et manipuler les processus biologiques grâce à la formation et/ou la rupture contrôlée de liaisons chimiques » – IBMM, Amphithéâtre Balard Sébastien Papot is professor at Poitiers University and the head of the “organic synthesis” team at the IC2MP. He is […]
41% of tardigrade genes do not exist in any other living species, and some of them have exceptional properties for combating extreme stress (temperature, pressure, absolute zero, outer space, etc.). Professor Simon Galas’s team has just published an article in the American journal PLOS ONE, revealing for the first time the different strategies used by […]
THERAPEUTIC PEPTIDES AND THE CONTROL OF THEIR CHIRALITY : MAJOR CHALLENGE IN ANALYTICAL SCIENCES This thesis is part of a large-scale research project aiming at probing the chirality of therapeutic peptides. This project is bringing together the vast majority of the IBMM analytical team (5 teacher-researchers, 3 technical staff). Preliminary work was carried out as […]
Institut des Biomolécules Max Mousseron
UMR 5247
Pôle Chimie Balard Recherche
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