Internship 6 months : synthesis of 3’,5’-biphosphate nucleosides analogues modified at the 2’position for RNA detection
RNA molecules perform various functional roles in biological processes such as transcription or epigenetic regulation of genes. Chemical modifications and labeling of RNA are of particular importance to study RNA in vitro, or investigate its interactions with proteins.1 Chemo-enzymatic synthesis enables the incorporation of modified nucleosides with diverse functional groups into RNA.2 This method involves […]