BUT2-3/2A Internship: Investigation of Protein/Nanoparticle Release from Hybrid Silylated Hydrogels: Impact of Overall Charge (ADAPT Project)
Project Description
Biopolymer-based hydrogels are promising matrices for the controlled delivery of therapeutic agents.
The ADAPT project aims to develop a new generation of hydrogels formed through sol-gel crosslinking of silylated polysaccharides. The objective is to modulate electrostatic interactions between the hydrogel matrix and the encapsulated proteins or nanoparticles without relying on covalent bonds. This approach aims to develop a versatile platform adaptable to different types of encapsulated cargo and release kinetics.
The aim of this internship is to design and formulate tunable hydrogels using the sol-gel process for the controlled delivery of proteins or nanoparticles.
Student Missions
During the internship, you will be involved in:
- Hydrogel formulation: Preparing and optimizing bulk hydrogel matrices based on silylated biopolymers and silylated amino acids or peptides;
- Encapsulation and release kinetics: Evaluating maximum encapsulation capacity and monitoring the release kinetics of model proteins over several days;
- Analytical characterization: Performing biochemical assays (BCA), UV-Vis spectroscopy, and rheological characterization;
- Physicochemical characterization: Investigating the structural and surface properties of the materials, including zeta potential measurements, stability, and degradation.
Candidate Profile
We are looking for a second- or third-year BUT student (French University Bachelor of Technology) or a second-year engineering student with a strong interest in biomaterials.
The ideal candidate should demonstrate:
- Excellent organizational skills;
- A rigorous and methodical approach to experimental work;
- Proficiency in processing and analyzing experimental data, particularly using Excel.
Practical Information
Duration: 2–3 months
Starting date: March/April 2027
Host Institute: Institut des Biomolécules Max Mousseron (IBMM)
Internship location:
CNRS Campus
1919 route de Mende
Montpellier, France
Supervisors – Contact:
Project funding: University of Montpellier – France 2030 Programme UM2030-IDéES
How to Apply
Applicants are invited to send their CV and cover letter by November 16, 2026, to: