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Synthèse de Lipides Bioactifs : publications de l’équipe/Brevets

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Publications 2017

Amor, A. M. C.-D., Aguayo, E., Collado-González, J., Guy, A., Galano, J.-M., Durand, T. & Gil-Izquierdo, Á. Impact of processing conditions on the phytoprostanes profile of three types of nut kernels. Free Radic. Res. 51, 141–147 (2017).

Bosviel, R., Joumard-Cubizolles, L., Chinetti-Gbaguidi, G., Bayle, D., Copin, C., Hennuyer, N., Duplan, I., Staels, B., Zanoni, G., Porta, A., Balas, L., Galano, J. M., Oger, C., Mazur, A., Durand, T. & Gladine, C. DHA-derived oxylipins, neuroprostanes and protectins, differentially and dose-dependently modulate the inflammatory response in human macrophages : Putative mechanisms through PPAR activation. Free Radic Biol Med 103, 146–154 (2017).

Collado-González, J., Grosso, C., Valentão, P., Andrade, P. B., Ferreres, F., Durand, T., Guy, A., Galano, J.-M., Torrecillas, A. & Gil-Izquierdo, Á. Inhibition of α-glucosidase and α-amylase by Spanish extra virgin olive oils : The involvement of bioactive compounds other than oleuropein and hydroxytyrosol. Food Chem. 235, 298–307 (2017).

Cuyamendous, C., Leung, K. S., Bultel-Poncé, V., Guy, A., Durand, T., Galano, J.-M., Lee, J. C.-Y. & Oger, C. Total Synthesis and in Vivo Quantitation of Phytofurans Derived from α-Linolenic Acid. Eur. J. Org. Chem. 2017, 2486–2490 (2017).

De Las Heras-Gomez, I., Medina, S., Casas-Pina, T., Marin-Soler, L., Tomas, A., Martinez-Hernandez, P., Oger, C., Galano, J. M., Durand, T., Jimeno, L., Llorente, S., Lozoya, E., Ferreres, F. & Gil-Izquierdo, A. Potential applications of lipid peroxidation products - F4-neuroprostanes, F3-neuroprostanesn-6 DPA, F2-dihomo-isoprostanes and F2-isoprostanes - in the evaluation of the allograft function in renal transplantation. Free Radic Biol Med 104, 178–184 (2017).

Demion, M., Oger, C., Vigor, C., Thireau, J., Guennec, J.-Y. L., Durand, T., Galano, J.-M. & Lee, J. C.-Y. Two sides of the same coin : NEO-PUFAs in Rett syndrome and post-infarction cardiac arrhythmias. Eur. J. Lipid Sci. Technol. 119, n/a-n/a (2017).

Galano, J.-M., Lee, Y. Y., Oger, C., Vigor, C., Vercauteren, J., Durand, T., Giera, M. & Lee, J. C.-Y. Isoprostanes, neuroprostanes and phytoprostanes : An overview of 25years of research in chemistry and biology. Prog. Lipid Res. 68, 83–108 (2017).

Galano, J.-M., Oger, C., Bultel-Poncé, V., REVERSAT, G., Guy, A., Vercauteren, J., Vigor, C. & Durand, T. F3-Isoprostanes and 4-Neuroprostanes : Non-enzymatic Cyclic Oxygenated metabolites of Omega-3 polyunsaturated Fatty Acids  : biomarkers and Bioactive Lipids. Fats Life 22, 25–32 (2017).

Garcia-Flores, L. A., Medina, S., Martinez-Hernandez, P., Oger, C., Galano, J. M., Durand, T., Casas-Pina, T., Ferreres, F. & Gil-Izquierdo, A. Snapshot situation of oxidative degradation of the nervous system, kidney, and adrenal glands biomarkers-neuroprostane and dihomo-isoprostanes-urinary biomarkers from infancy to elderly adults. Redox Biol 11, 586–591 (2017).

Joumard-Cubizolles, L., Lee, J. C.-Y., Vigor, C., Leung, H. H., Bertrand-Michel, J., Galano, J.-M., Mazur, A., Durand, T. & Gladine, C. Insight into the contribution of isoprostanoids to the health effects of omega 3 PUFAs. Prostaglandins Other Lipid Mediat. 133, 111–122 (2017).

Lai, K. P., Lee, J. C.-Y., Wan, H. T., Li, J. W., Wong, A. Y.-M., Chan, T. F., Oger, C., Galano, J.-M., Durand, T., Leung, K. S., Leung, C. C., Li, R. & Wong, C. K.-C. Effects of in Utero PFOS Exposure on Transcriptome, Lipidome, and Function of Mouse Testis. Environ. Sci. Technol. 51, 8782–8794 (2017).

Leung, K. S., Chan, H. F., Leung, H. H., Galano, J.-M., Oger, C., Durand, T. & Lee, J. C.-Y. Short-time UVA exposure to human keratinocytes instigated polyunsaturated fatty acid without inducing lipid peroxidation. Free Radic. Res. 51, 269–280 (2017).

Marhuenda, J., Medina, S., Martínez-Hernández, P., Arina, S., Zafrilla, P., Mulero, J., Oger, C., Galano, J.-M., Durand, T., Ferreres, F. & Gil-Izquierdo, A. Melatonin and hydroxytyrosol protect against oxidative stress related to the central nervous system after the ingestion of three types of wine by healthy volunteers. Food Funct. 8, 64–74 (2017).

Marhuenda, J., Medina, S., Martínez-Hernández, P., Arina, S., Zafrilla, P., Mulero, J., Oger, C., Galano, J.-M., Durand, T., Solana, A., Ferreres, F., López-García, J. J. & Gil-Izquierdo, A. Effect of the dietary intake of melatonin- and hydroxytyrosol-rich wines by healthy female volunteers on the systemic lipidomic-related oxylipins. Food Funct 8, 3745–3757 (2017).

Medina, S., Collado-González, J., Ferreres, F., Londoño-Londoño, J., Jiménez-Cartagena, C., Guy, A., Durand, T., Galano, J.-M. & Gil-Izquierdo, A. Quantification of phytoprostanes – bioactive oxylipins – and phenolic compounds of Passiflora edulis Sims shell using UHPLC-QqQ-MS/MS and LC-IT-DAD-MS/MS. Food Chem. 229, 1–8 (2017).

Pérez-Berezo, T., Pujo, J., Martin, P., Le Faouder, P., Galano, J.-M., Guy, A., Knauf, C., Tabet, J. C., Tronnet, S., Barreau, F., Heuillet, M., Dietrich, G., Bertrand-Michel, J., Durand, T., Oswald, E. & Cenac, N. Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917. Nat. Commun. 8, (2017).

Pinciroli, M., Domínguez-Perles, R., Abellán, A., Guy, A., Durand, T., Oger, C., Galano, J. M., Ferreres, F. & Gil-Izquierdo, A. Comparative Study of the Phytoprostane and Phytofuran Content of indica and japonica Rice ( Oryza sativa L.) Flours. J. Agric. Food Chem. 65, 8938–8947 (2017).

Rosell, M., Villa, M., Durand, T., Galano, J.-M., Vercauteren, J. & Crauste, C. Total Syntheses of Two bis-Allylic-Deuterated DHA Analogues. Asian J. Org. Chem. 6, 322–334 (2017).

Roy, J., Fauconnier, J., Oger, C., Farah, C., Angebault-Prouteau, C., Thireau, J., Bideaux, P., Scheuermann, V., Bultel-Poncé, V., Demion, M., Galano, J.-M., Durand, T., Lee, J. C.-Y. & Le Guennec, J.-Y. Non-enzymatic oxidized metabolite of DHA, 4(RS)-4-F4t-neuroprostane protects the heart against reperfusion injury. Free Radic. Biol. Med. 102, 229–239 (2017).

Sánchez-Illana, Á., Thayyil, S., Montaldo, P., Jenkins, D., Quintás, G., Oger, C., Galano, J.-M., Vigor, C., Durand, T., Vento, M. & Kuligowski, J. Novel free-radical mediated lipid peroxidation biomarkers in newborn plasma. Anal. Chim. Acta 996, 88–97 (2017).

Shamseddin, A., Crauste, C., Durand, E., Villeneuve, P., Dubois, G., Durand, T., Vercauteren, J. & Veas, F. Resveratrol formulated with a natural deep eutectic solvent inhibits active matrix metalloprotease-9 in hormetic conditions : Resveratrol NADES formulation and hormesis. Eur. J. Lipid Sci. Technol. 119, 1700171 (2017).

Publications 2011 /2016

• 2016

« Dihydroxylated E,E,Z-docosatrienes. An overview of their synthesis and biological significance », BALAS L., DURAND T. Prog Lipid Res. 61, 1-18 (2016).

« Non enzymatic metabolites of polyunsaturated fatty acids : friend or foe », BULTEL-PONCE V., DURAND T., GUY A., OGER C., GALANO J. M. Ocl-Oilseeds and Fats Crops and Lipids. 23(2016).

« Effect of the season on the free phytoprostane content in Cornicabra extra virgin olive oil from deficit-irrigated olive trees », COLLADO-GONZALEZ J., PEREZ-LOPEZ D., MEMMI H., GIJON M. C., MEDINA S., DURAND T., GUY A., GALANO J. M., FERNANDEZ D. J., CARRO F., FERRERES F., TORRECILLAS A., GIL-IZQUIERDO A. J. Sci. Food Agr. 96, 1585-1592 (2016).

« Abnormal N-glycosylation pattern for brain nucleotide pyrophosphatase-5 (NPP-5) in Mecp2-mutant murine models of Rett syndrome », CORTELAZZO A., DE FELICE C., GUERRANTI R., SIGNORINI C., LEONCINI S., PECORELLI A., SCALABRI F., MADONNA M., FILOSA S., DELLA GIOVAMPAOLA C., CAPONE A., DURAND T., MIRASOLE C., ZOLLA L., VALACCHI G., CICCOLI L., GUY J., D’ESPOSITO M., HAYEK J. Neurosci Res. 105, 28-34 (2016).

« Omega-3 polyunsaturated lipophenols, how and why ? », CRAUSTE C., ROSELL M., DURAND T., VERCAUTEREN J. Biochimie. 120, 62-74 (2016).

« Rett syndrome : An autoimmune disease ? », DE FELICE C., LEONCINI S., SIGNORINI C., CORTELAZZO A., ROVERO P., DURAND T., CICCOLI L., PAPINI A. M., HAYEK J. Autoimmun Rev. 15, 411-416 (2016).

« Simultaneous quantitative profiling of 20 isoprostanoids from omega-3 and omega-6 polyunsaturated fatty acids by LC-MS/MS in various biological samples », DUPUY A., LE FAOUDER P., VIGOR C., OGER C., GALANO J. M., DRAY C., LEE J. C., VALET P., GLADINE C., DURAND T., BERTRAND-MICHEL J. Anal Chim Acta. 921, 46-58 (2016).

« Assessment of oxidative stress biomarkers - neuroprostanes and dihomo-isoprostanes - in the urine of elite triathletes after two weeks of moderate-altitude training », GARCIA-FLORES L. A., MEDINA S., CEJUELA R., MARTINEZ-SANZ J. M., OGER C., GALANO J. M., DURAND T., CASAS-PINA T., MARTINEZ-HERNANDEZ P., FERRERES F., GIL-IZQUIERDO A. Free Radic Res. 50, 485-494 (2016).

« Non-enzymatic cyclic oxygenated metabolites of omega-3 polyunsaturated fatty acid : Bioactive drugs ? », ROY J., LE GUENNEC J. Y., GALANO J. M., THIREAU J., BULTEL-PONCE V., DEMION M., OGER C., LEE J. C., DURAND T. Biochimie. 120, 56-61 (2016).

« MECP2 Duplication Syndrome : Evidence of Enhanced Oxidative Stress. A Comparison with Rett Syndrome », SIGNORINI C., DE FELICE C., LEONCINI S., MOLLER R. S., ZOLLO G., BUONI S., CORTELAZZO A., GUERRANTI R., DURAND T., CICCOLI L., D’ESPOSITO M., RAVN K., HAYEK J. PLoS One. 11, e0150101 (2016).

• 2015

« Nonenzymatic alpha-Linolenic Acid Derivatives from the Sea : Macroalgae as Novel Sources of Phytoprostanes », BARBOSA M., COLLADO-GONZALEZ J., ANDRADE P. B., FERRERES F., VALENTAO P., GALANO J. M., DURAND T., GIL-IZQUIERDO A. J Agric Food Chem. 63, 6466-6474 (2015).

« Phytoprostanes in almonds : identification, quantification, and impact of cultivar and type of cultivation », CARRASCO-DEL AMOR A. M., COLLADO-GONZALEZ J., AGUAYO E., GUY A., GALANO J. M., DURAND T., GIL-IZQUIERDO A. Rsc Advances. 5, 51233-51241 (2015).

« Hyperoxia Elevates Adrenic Acid Peroxidation in Marine Fish and Is Associated with Reproductive Pheromone Mediators », CHUNG M. L. S., GALANO J. M., OGER C., DURAND T., LEE J. C. Y. Marine Drugs. 13, 2215-2232 (2015).

« Phytoprostanes », COLLADO-GONZALEZ J., DURAND T., FERRERES F., MEDINA S., TORRECILLAS A., GIL-IZQUIERDO A. Lipid Technology. 27, 127-130 (2015).

« New UHPLC-QqQ-MS/MS method for quantitative and qualitative determination of free phytoprostanes in foodstuffs of commercial olive and sunflower oils », COLLADO-GONZALEZ J., MEDINA S., DURAND T., GUY A., GALANO J. M., TORRECILLAS A., FERRERES F., GIL-IZQUIERDO A. Food Chemistry. 178, 212-220 (2015).

« The phytoprostane content in green table olives is influenced by Spanish-style processing and regulated deficit irrigation », COLLADO-GONZALEZ J., MORIANA A., GIRON I. F., CORELL M., MEDINA S., DURAND T., GUY A., GALANO J. M., VALERO E., GARRIGUES T., FERRERES F., MORENO F., TORRECILLAS A., GIL-IZQUIERDO A. Lwt-Food Science and Technology. 64, 997-1003 (2015).

« Water Deficit during Pit Hardening Enhances Phytoprostanes Content, a Plant Biomarker of Oxidative Stress, in Extra Virgin Olive Oil », COLLADO-GONZALEZ J., PEREZ-LOPEZ D., MEMMI H., GIJON M. C., MEDINA S., DURAND T., GUY A., GALANO J. M., FERRERES F., TORRECILLAS A., GIL-IZQUIERDO A. J. Agr. Food Chem. 63, 3784-3792 (2015).

« Synthesis and discovery of phytofurans : metabolites of alpha-linolenic acid peroxidation », CUYAMENDOUS C., LEUNG K. S., DURAND T., LEE J. C. Y., OGER C., GALANO J. M. Chemical Communications. 51, 15696-15699 (2015).

« Oxidative stress : a hallmark of Rett syndrome », DE FELICE C., SIGNORINI C., LEONCINI S., DURAND T., CICCOLI L., HAYEK J. Future Neurol. 10, 179-182 (2015).

« Total Syntheses and In Vivo Quantitation of Novel Neurofuran and Dihomo-isofuran Derived from Docosahexaenoic Acid and Adrenic Acid », DE LA TORRE A., LEE Y. Y., MAZZONI A., GUY A., BULTEL-PONCÉ V., DURAND T., OGER C., LEE J. C.-Y., GALANO J.-M. Chemistry A European Journal. 21, 2442-2446 (2015).

« Regioselective synthesis of diacylglycerol rosmarinates and evaluation of their antioxidant activity in fibroblasts », DURAND E., BAYRASY C., LAGUERRE M., BAROUH N., LECOMTE J., DURAND T., BALAS L., WRUTNIAK-CABELLO C., CABELLO G., VILLENEUVE P. European Journal of Lipid Science and Technology. 117, 1159-1170 (2015).

« Non-enzymatic cyclic oxygenated metabolites of adrenic, docosahexaenoic, eicosapentaenoic and alpha-linolenic acids ; bioactivities and potential use as biomarkers », GALANO J. M., LEE J. C. Y., GLADINE C., COMTE B., LE GUENNEC J. Y., OGER C., DURAND T. Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids. 1851, 446-455 (2015).

« Special Issue on »Analytical Methods for Oxidized Biomolecules and Antioxidants« The use of isoprostanoids as biomarkers of oxidative damage, and their role in human dietary intervention studies », GALANO J. M., LEE Y. Y., DURAND T., LEE J. C. Y. Free Radical Research. 49, 583-598 (2015).

« Facile synthesis of cyclopentenone B1- and L1-type phytoprostanes », GUY A., FLANAGAN S., DURAND T., OGER C., GALANO J.-M. Front Chem. 3, 1-10 (2015).

« Differential Mobility Separation of Leukotrienes and Protectins », JONASDOTTIR H. S., PAPAN C., FABRITZ S., BALAS L., DURAND T., HARDARDOTTIR I., FREYSDOTTIR J., GIERA M. Analytical Chemistry. 87, 5036-5040 (2015).

« Prenatal exposure to the contaminant perfluorooctane sulfonate elevates lipid peroxidation during mouse fetal development but not in the pregnant dam », LEE Y. Y., WONG C. K., OGER C., DURAND T., GALANO J. M., LEE J. C. Free Radic Res. 49, 1015-1025 (2015).

« Cytokine Dysregulation in MECP2- and CDKL5-Related Rett Syndrome : Relationships with Aberrant Redox Homeostasis, Inflammation, and omega-3 PUFAs », LEONCINI S., DE FELICE C., SIGNORINI C., ZOLLO G., CORTELAZZO A., DURAND T., GALANO J. M., GUERRANTI R., ROSSI M., CICCOLI L., HAYEK J. Oxid Med Cell Longev. 2015, 421624 (2015).

« Current development in non-enzymatic lipid peroxidation products, isoprostanoids and isofuranoids, in novel biological samples », LEUNG K. S., GALANO J. M., DURAND T., LEE J. C. Free Radic Res. 49, 816-826 (2015).

« Dependency of Phytoprostane Fingerprints of Must and Wine on Viticulture and Enological Processes », MARHUENDA J., MEDINA S., DIAZ-CASTRO A., MARTINEZ-HERNANDEZ P., ARINA S., ZAFRILLA P., MULERO J., OGER C., GALANO J. M., DURAND T., FERRERES F., GIL-IZQUIERDO A. J. Agr. Food Chem. 63, 9022-9028 (2015).

« Dihomo-isoprostanes-nonenzymatic metabolites of AdA-are higher in epileptic patients compared to healthy individuals by a new ultrahigh pressure liquid chromatography-triple quadrupole-tandem mass spectrometry method », MEDINA S., DE MIGUEL-ELIZAGA I., OGER C., GALANO J.-M., DURAND T., MARTINEZ-VILLANUEVA M., CASTILLO M. L. G.-D., VILLEGAS-MARTINEZ I., FERRERES F., MARTINEZ-HERNANDEZ P., GIL-IZQUIERDO A. Free Rad Biol Med. 79, 154-163 (2015).

« Profiling and relative quantification of multiply nitrated and oxidized fatty acids », MILIC I., GRIESSER E., VEMULA V., IEDA N., NAKAGAWA H., MIYATA N., GALANO J. M., OGER C., DURAND T., FEDOROVA M. Anal Bioanal Chem. 407, 5587-5602 (2015).

« Nonenzymatic lipid mediators, neuroprostanes, exert the antiarrhythmic properties of docosahexaenoic acid », ROY J., OGER C., THIREAU J., ROUSSEL J., MERCIER-TOUZET O., FAURE D., PINOT E., FARAH C., TABER D. F., CRISTOL J. P., LEE J. C., LACAMPAGNE A., GALANO J. M., DURAND T., LE GUENNEC J. Y. Free Radic Biol Med. 86, 269-278 (2015).

« Polymeric nanocapsules prevent oxidation of core-loaded molecules : evidence based on the effects of docosahexaenoic acid and neuroprostane on breast cancer cells proliferation », ROY J., OLIVEIRA L. T., OGER C., GALANO J. M., BULTEL-PONCE V., RICHARD S., GUIMARAES A. G., VILELA J. M., ANDRADE M. S., DURAND T., BESSON P., MOSQUEIRA V. C., LE GUENNEC J. Y. J Exp Clin Cancer Res. 34, 155 (2015).

« Erythrocyte cytoskeletal-plasma membrane protein network in Rett syndrome : effects of -3 polyunsaturated fatty acids », A. CORTELAZZO, C. DE FELICE, R. GUERRANTI, R. LEONCINI, A. BARDUCCI, A. GAGLIARDI, A. ARMINI, S. LEONCINI, C. SIGNORINI, G. ZOLLO, A. PECORELLI, E. PACCAGNINI, M. GENTILE, L. BINI T. DURAND, J-M. GALANO, M. ROSSI, G. VALACHI, L. CICCOLI, J. HAYEK. Current Proteomics, 12, 217-226 (2015).

• 2014

« Oxidative Stress and Rett Syndrome », DE FELICE C., SIGNORINI C., LEONCINI S., PECORELLI A., DURAND T., VALACCHI G., CICCOLI L., HAYEK J. Minerva Pediatr. 66, 41-62 (2014).

« Confusion between protectin D1 (PD1) and its isomer protectin DX (PDX). An overview on the dihydroxy-docosatrienes described to date », BALAS L., GUICHARDANT M., DURAND T., LAGARDE M. Biochimie. 99C, 1-7 (2014).

« Acidi grassi polinsaturi w-3 e stato infiammatorio subclinico nella sindrome di Rett », CORTELAZZO A., DE FELICE C., SIGNORINI C., GUERRANTI R., LEONCINI S., PECORELLI A., DURAND T., GALANO J.-M., OGER C., ZOLLO G., MONTOMOLI B., LANDI C., BINI L., VALACCHI G., CICCOLI L., HAYEK J. L’INTEGRATORE NUTRIZIONALE. 26-34 (2014).

« Synthesis and Evaluation of Polyunsaturated Fatty Acid-Phenol Conjugates as Anti-Carbonyl-Stress Lipophenols », CRAUSTE C., VIGOR C., BRABET P., PICQ M., LAGARDE M., HAMEL C., DURAND T., VERCAUTEREN J. European Journal of Organic Chemistry. 4548-4561 (2014).

« A Versatile and Stereocontrolled Total Synthesis of Dihydroxylated Docosatrienes Containing a Conjugated E,E,Z-Triene », DAYAKER G., DURAND T., BALAS L. Chemistry-a European Journal. 20, 2879-2887 (2014).

« Total Synthesis of Neuroprotectin D1 Analogues Derived from Omega-6 Docosapentaenoic Acid (DPA) and Adrenic Acid (AdA) from a Common Pivotal, Late-Stage Intermediate », DAYAKER G., DURAND T., BALAS L. J Org Chem. 79, 2657-2665 (2014).

« Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome », DE FELICE C., DELLA RAGIONE F., SIGNORINI C., LEONCINI S., PECORELLI A., CICCOLI L., SCALABRI F., MARRACINO F., MADONNA M., BELMONTE G., RICCERI L., DE FILIPPIS B., LAVIOLA G., VALACCHI G., DURAND T., GALANO J. M., OGER C., GUY A., BULTEL-PONCE V., GUY J., FILOSA S., HAYEK J., D’ESPOSITO M. Neurobiol Dis. 68C, 66-77 (2014).

« [Oxidative stress and Rett syndrome.] », DE FELICE C., SIGNORINI C., LEONCINI S., PECORELLI A., DURAND T., VALACCHI G., CICCOLI L., HAYEK J. Minerva Pediatr. 66, 41-62 (2014).

« Synthesis, Discovery, and Quantitation of Dihomo-Isofurans : Biomarkers for In Vivo Adrenic Acid Peroxidation », DE LA TORRE A., LEE Y. Y., OGER C., SANGILD P. T., DURAND T., LEE J. C. Y., GALANO J. M. Angewandte Chemie-International Edition. 53, 6249-6252 (2014).

« Development of the First Oral Bioprecursors of Bis-alkylguanidine Antimalarial Drugs », DEGARDIN M., WEIN S., DUCKERT J. F., MAYNADIER M., GUY A., DURAND T., ESCALE R., VIAL H., VO-HOANG Y. ChemMedChem. 9, 300-304 (2014).

« Lipid Profiling following Intake of the Omega 3 Fatty Acid DHA Identifies the Peroxidized Metabolites F4-Neuroprostanes as the Best Predictors of Atherosclerosis Prevention », GLADINE C., NEWMAN J. W., DURAND T., PEDERSEN T. L., GALANO J. M., DEMOUGEOT C., BERDEAUX O., PUJOS-GUILLOT E., MAZUR A., COMTE B. PLoS One. 9, e89393 (2014).

« Oxygenated Metabolites of n-3 Polyunsaturated Fatty Acids as Potential Oxidative Stress Biomarkers : Total Synthesis of 8-F3t -IsoP, 10-F4t -NeuroP and [D4 ]-10-F4t -NeuroP », GUY A., OGER C., HEPPEKAUSEN J., SIGNORINI C., DE FELICE C., FURSTNER A., DURAND T., GALANO J. M. Chemistry. 20, 6374-6380 (2014).

« Recent Approaches To The Total Synthesis Of Phytoprostanes, Isoprostanes And Neuroprostanes As Important Products Of Lipid Oxidative Stress And Biomarkers Of Disease », JAHN E., DURAND T., GALANO J.-M., JAHN U. Chem. Listy. 108, 301-319 (2014).

« Role of the Non-enzymatic Metabolite of Eicosapentaenoic Acid, 5-epi-5-F3t-Isoprostane in the Regulation of [3H]d-Aspartate Release in Isolated Bovine Retina », JAMIL J., BANKHELE P., SALVI A., MANNIX J. E., OGER C., GUY A., GALANO J.-M., DURAND T., NJIE-MBYE Y., OHIA S., OPERE C. Neurochem Res. 39, 2360-2369 (2014).

« Effects of omega -3 PUFAs Supplementation on Myocardial Function and Oxidative Stress Markers in Typical Rett Syndrome », MAFFEI S., DE FELICE C., CANNARILE P., LEONCINI S., SIGNORINI C., PECORELLI A., MONTOMOLI B., LUNGHETTI S., CICCOLI L., DURAND T., FAVILLI R., HAYEK J. Mediators Inflamm. 2014, 983178 (2014).

« Nonenzymatic oxygenated metabolites of alpha-linolenic acid B1- and L1-phytoprostanes protect immature neurons from oxidant injury and promote differentiation of oligodendrocyte progenitors through PPAR-gamma activation », MINGHETTI L., SALVI R., LAVINIA SALVATORI M., AJMONE-CAT M. A., DE NUCCIO C., VISENTIN S., BULTEL-PONCE V., OGER C., GUY A., GALANO J. M., GRECO A., BERNARDO A., DURAND T. Free Radic Biol Med. 73, 41-50 (2014).

« A Huge PVDF Adsorption Difference Between Resveratrol and epsilon-Viniferin Allows to Quantitatively Purify Them and to Assess Their Anti-Tyrosinase Property », MOREL-SALMI C., JULIA A., VIGOR C., VERCAUTEREN J. Chromatographia. 77, 957-961 (2014).

« Altered erythrocyte membrane fatty acid profile in typical Rett syndrome : Effects of omega-3 polyunsaturated fatty acid supplementation », SIGNORINI C., DE FELICE C., LEONCINI S., DURAND T., GALANO J.-M., CORTELAZZO A., ZOLLO G., GUERRANTI R., GONNELLI S., CAFFARELLI C., ROSSI M., PECORELLI A., VALACCHI G., CICCOLI L., HAYEK J. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA). 91, 183-193 (2014).

« Redox imbalance and morphological changes in skin fibroblasts in typical Rett syndrome », SIGNORINI C., LEONCINI S., DE FELICE C., PECORELLI A., MELONI I., ARIANI F., MARI F., AMABILE S., PACCAGNINI E., GENTILE M., BELMONTE G., ZOLLO G., VALACCHI G., DURAND T., GALANO J. M., CICCOLI L., RENIERI A., HAYEK J. Oxid Med Cell Longev. 2014, 195935 (2014).

« Flavonoïds from Euphorbia guyoniana Boissier & Reuter », SMARA O., JULIA A., MORAL-SALMI C., VIGOR C., VERCAUTEREN J., BELGACEM L. J Life Sci. 8, 544-551 (2014).

« Non-enzymatic lipid oxidation products in biological systems : assessment of the metabolites from polyunsaturated fatty acids », VIGOR C., BERTRAND-MICHEL J., PINOT E., OGER C., VERCAUTEREN J., LE FAOUDER P., GALANO J. M., LEE J. C., DURAND T. J Chromatogr B Analyt Technol Biomed Life Sci. 964, 65-78 (2014).

• 2013

« Erythrocyte Shape Abnormalities, Membrane Oxidative Damage, and beta -Actin Alterations : An Unrecognized Triad in Classical Autism », CICCOLI L., DE FELICE C., PACCAGNINI E., LEONCINI S., PECORELLI A., SIGNORINI C., BELMONTE G., GUERRANTI R., CORTELAZZO A., GENTILE M., ZOLLO G., DURAND T., VALACCHI G., ROSSI M., HAYEK J. Mediators Inflamm. 2013, 432616 (2013).

« Effects of omega -3 Polyunsaturated Fatty Acids on Plasma Proteome in Rett Syndrome », DE FELICE C., CORTELAZZO A., SIGNORINI C., GUERRANTI R., LEONCINI S., PECORELLI A., DURAND T., GALANO J. M., OGER C., ZOLLO G., MONTOMOLI B., LANDI C., BINI L., VALACCHI G., CICCOLI L., HAYEK J. Mediators Inflamm. 2013, 723269 (2013).

« Acidi grassi ù-3 nella sindrome di Rett. Studio clinico al primo stadio della malattia », DE FELICE C., LEONCINI S., SIGNORINI C., PECORELLI A., DURAND T., GALANO J.-M., OGER C., CORTELAZZO A., MONTOMOLI B., ZOLLO G., VALACCHI G., CICCOLI L., HAYEK J. L’INTEGRATORE NUTRIZIONALE. 16, 9-14 (2013).

« Fatty Acids and Autism Spectrum Disorders : The Rett Syndrome Conundrum », DE FELICE C., SIGNORINI C., LEONCINI S., PECORELLI A., DURAND T., GALANO J.-M., BULTEL-PONCÉ V., GUY A., OGER C., ZOLLO G., VALACCHI G., CICCOLI L., HAYEK J. food and nutrition sciences. 71-75 (2013).

« F-2-Dihomo-isoprostanes and brain white matter damage in stage 1 Rett syndrome », DURAND T., DE FELICE C., SIGNORINI C., OGER C., BULTEL-PONCE V., GUY A., GALANO J. M., LEONCINI S., CICCOLI L., PECORELLI A., VALACCHI G., HAYEK J. Biochimie. 95, 86-90 (2013).

« Isoprostanes and neuroprostanes : total synthesis, biological activity and biomarkers of oxidative stress in humans », GALANO J. M., MAS E., BARDEN A., MORI T. A., SIGNORINI C., DE FELICE C., BARRETT A., OPERE C., PINOT E., SCHWEDHELM E., BENNDORF R., ROY J., LE GUENNEC J. Y., OGER C., DURAND T. Prostaglandins Other Lipid Mediat. 107, 95-102 (2013).

« Are Alkyne Reductions Chemo-, Regio-, and Stereoselective Enough To Provide Pure (Z)-Olefins in Polyfunctionalized Bioactive Molecules ? », OGER C., BALAS L., DURAND T., GALANO J.-M. Chem. Rev. 113, 1313-1350 (2013).

« Regulation of Potassium-induced [3H]D-Aspartate Release from Isolated Bovine Retina by 5-epi-5-F3t-Isoprostane : Role of Prostanoid Receptors », OPERE C. A., JAMIL J., SALVI A., BANKHELE P., FLOWERS A., FLOYD N., DURAND T., GALANO J.-M., GUY A., OGER C., NJIE-MBYE Y. F., KULKARNI M. S., OHIA S. FASEB J. 27, 1174.1176 (2013).

« Isoprostanes and 4-Hydroxy-2-nonenal : Markers or Mediators of Disease ? Focus on Rett Syndrome as a Model of Autism Spectrum Disorder », SIGNORINI C., DE FELICE C., DURAND T., OGER C., GALANO J.-M., LEONCINI S., PECORELLI A., VALACCHI G., CICCOLI L., HAYEK J. Oxid. Med. Cell. Longev. 2013, 1-10 (2013).

• 2012

« Is there a role for isofurans and neuroprostanes in pre-eclampsia and normal pregnancy ? », BARDEN A. E., CORCORAN T. B., MAS E., DURAND T., GALANO J. M., ROBERTS L. J., PAECH M., MUCHATUTA N. A., PHILLIPS M., MORI T. A. Antioxid Redox Signal. 16, 165-169 (2012).

« The Fraction of alpha-Linolenic Acid Present in the sn-2 Position of Structured Triacylglycerols Decreases in Lymph Chylomicrons and Plasma Triacylglycerols during the Course of Lipid Absorption in Rats », COUEDELO L., VAYSSE C., VAIQUE E., GUY A., GOSSE I., DURAND T., PINET S., CANSELL M., COMBE N. J Nutr. 142, 70-75 (2012).

« Partial rescue of Rett syndrome by omega-3 polyunsaturated fatty acids (PUFAs) oil », DE FELICE C., SIGNORINI C., DURAND T., CICCOLI L., LEONCINI S., D’ESPOSITO M., FILOSA S., OGER C., GUY A., BULTEL-PONCE V., GALANO J. M., PECORELLI A., DE FELICE L., VALACCHI G., HAYEK J. Genes Nutr. 7, 447-458 (2012).

« The Role of Oxidative Stress in Rett Syndrome : an overview », DE FELICE C., SIGNORINI C., LEONCINI S., PECORELLI A., DURAND T., VALACCHI G., CICCOLI L., HAYEK J. Ann. NY Acad. Sci. 1259, 121-135 (2012).

« Evaluation of bis-alkylamidoxime o-alkylsulfonates as orally available antimalarials », DEGARDIN M., WEIN S., GOUNI S., TRAN VAN BA C., DUCKERT J. F., DURAND T., ESCALE R., VIAL H., VO-HOANG Y. ChemMedChem. 7, 991-1001 (2012).

« Regulation of K+-induced 3H D-Aspartate Release by Synthetic Neuroprostanes in Isolated Bovine Retina », FLOWERS A. F., FLOYD N., KEDEY E., JAMIL J., DURAND T., GALANO J.-M., GUY A., NJIE-MBYE Y., OHIA S. E., OPERE C. A. Faseb J. 26, 843.844 (2012).

« Regulation of 3H d-aspartate release by the 5-F(2t)-isoprostane and its 5-epimer in isolated bovine retina », JAMIL J., WRIGHT A., HARRISON N., KEGEY E., FLOWERS A. F., FLYOD N. J., KOTERA C., GUY A., GALANO J. M., DURAND T., NJIE-MBYE Y. F., OHIA S. E., OPERE C. A. Neurochem Res. 37, 574-582 (2012).

« Systemic lipid peroxidation in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) », LEONCINI S., DE FELICE C., SIGNORINI C., PECORELLI A., DURAND T., GALANO J. M., OGER C., BULTEL-PONCE V., GUY A., BOSCHI S., CICCOLI L., HAYEK J. Eur. J. Neurol. 19, 101-101 (2012).

« Quercetin accumulates in nuclear structures and triggers specific gene expression in epithelial cells », NOTAS G., NIFLI A. P., KAMPA M., PELEKANOU V., ALEXAKI V. I., THEODOROPOULOS P., VERCAUTEREN J., CASTANAS E. J Nutr Biochem. 23, 656-666 (2012).

« Total Syntheses of Isoprostanes Derived from Adrenic Acid and EPA », OGER C., BULTEL-PONCÉ V., GUY A., DURAND T., GALANO J.-M. Eur. J. Org. Chem. 2012, 2621-2634 (2012).

« Tuberculosis : The drug development pipeline at a glance. », VILLEMAGNE B., CRAUSTE C., FLIPO M., BAULARD A., DÉPREZ B., WILLAND N. Eur. J. Med. Chem. 51, 1-16 (2012).

• 2011

« The effects of oxidation products of arachidonic acid and n3 fatty acids on vascular and platelet function », BARDEN A., MAS E., HENRY P., DURAND T., GALANO J. M., ROBERTS L. J., CROFT K. D., MORI T. A. Free Radic Res. 45, 469-476 (2011).

« Synthesis of cysteinyl leukotrienes in human endothelial cells : subcellular localization and autocrine signaling through the CysLT2 receptor », CARNINI C., ACCOMAZZO M. R., BORRONI E., VITELLARO-ZUCCARELLO L., DURAND T., FOLCO G., ROVATI G. E., CAPRA V., SALA A. Faseb J. 25, 3519-3528 (2011).

« Are Isofurans and Neuroprostanes Increased After Subarachnoid Hemorrhage and Traumatic Brain Injury ? », CORCORAN T. B., MAS E., BARDEN A. E., DURAND T., GALANO J. M., ROBERTS L. J., PHILLIPS M., HO K. M., MORI T. A. Antioxid Redox Signal. 15, 2663-2667 (2011).

« Asymmetric synthesis of new B-lactam lipopeptides as bacterial signal peptidase I inhibitors. », CRAUSTE C., FROEYEN M., ANNÉ J., HERDEWIJN P. Eur. J. Org. Chem. 19, 3437-3449 (2011).

« Synthesis of 2’,3’-Dideoxynucleoside Phosphoesters Using H-Phosphonate Chemistry on Soluble Polymer Support. », CRAUSTE C., PÉRIGAUD C., PEYROTTES S. J. Org. Chem. 76, 997-1000 (2011).

« F2-dihomo-isoprostanes as potential early biomarkers of lipid oxidative damage in Rett syndrome », DE FELICE C., SIGNORINI C., DURAND T., OGER C., GUY A., BULTEL-PONCE V., GALANO J. M., CICCOLI L., LEONCINI S., D’ESPOSITO M., FILOSA S., PECORELLI A., VALACCHI G., HAYEK J. J Lipid Res. 52, 2287-2297 (2011).

« Isoprostanes and phytoprostanes : Bioactive lipids », DURAND T., BULTEL-PONCE V., GUY A., EL FANGOUR S., ROSSI J. C., GALANO J. M. Biochimie. 93, 52-60 (2011).

« The Alphabet of Galactolipids in Arabidopsis Thaliana », IBRAHIM A., SCHÜTZ A.-L., GALANO J.-M., HERRFURTH C., FEUSSNER K., DURAND T., BRODHUN F., FEUSSNER I. Frontiers in plant science. 2, 1-24 (2011).

« Symmetrical choline-derived dications display strong anti-kinetoplastid activity », IBRAHIM H. M., AL-SALABI M. I., EL SABBAGH N., QUASHIE N. B., ALKHALDI A. A., ESCALE R., SMITH T. K., VIAL H. J., DE KONING H. P. J Antimicrob Chemother. 66, 111-125 (2011).

« Novel oligomeric proanthocyanidin derivatives interact with membrane androgen sites and induce regression of hormone-independent prostate cancer », KAMPA M., THEODOROPOULOU K., MAVROMATI F., PELEKANOU V., NOTAS G., LAGOUDAKI E. D., NIFLI A. P., MOREL-SALMI C., STATHOPOULOS E. N., VERCAUTEREN J., CASTANAS E. J Pharmacol Exp Ther. 337, 24-32 (2011).

« Role of prostanoid receptors in the inhibitory effect of synthetic isoprostanes on potassium-induced [3H]D-aspartate release in isolated bovine retina. », KEGEY E., JAMIL J. M., HARRISON N., DURAND T., GALANO J.-M., GUY A., NJIE-MBYE Y. F., OHIA S. E., OPERE C. A. Faseb J. 25, 799.794 (2011).

« Oxidative stress in Rett syndrome : Natural history, genotype, and variants », LEONCINI S., DE FELICE C., SIGNORINI C., PECORELLI A., DURAND T., VALACCHI G., CICCOLI L., HAYEK J. Redox Report. 16, 145-153 (2011).

« Pharmacokinetic properties and metabolism of a new potent antimalarial N-alkylamidine compound, M64, and its corresponding bioprecursors », MARGOUT D., GATTACCECA F., MOARBESS G., WEIN S., TRAN VAN BA C., LE PAPE S., BERGER O., ESCALE R., VIAL H. J., BRESSOLLE F. M. Eur J Pharm Sci. 42, 81-90 (2011).

Publications 2004 /2011

Journaux à comité de lecture

  • « An Overview on Isoprostane Research : from Chemistry to Clinical Medicine. » LJ ROBERTS II, T. DURAND, Chem. Phys Lipids 128, 1-2 (2004).
  • « Total Syntheses of Iso- and Neuroprostanes : New Insight in Lipid Chemistry. » T. DURAND, A. GUY, O. HENRY, A. ROLAND, S. BERNAD, J-P. VIDAL, J-C ROSSI, Chem. Phys Lipids 128, 15-33 (2004).
  • « Total Syntheses of the Eight Diastereoisomers of the Syn-Anti-Syn Phytoprostanes F1 Types I an II. » S. EL FANGOUR, A. GUY, V. DESPRES, J-P. VIDAL, J-C ROSSI, T. DURAND, J. Org. Chem 69, 2498-2503 (2004).
  • « Synthesis of a photoactivatable potential inhibitor of the anandamide re-uptake » L. BALAS, M. HELLAL, J-C. ROSSI, T. DURAND, Nat Product Res. 19, 419-423 (2005).
  • « Different pharmacological profile of two close related ester endocannabionoid analogs » M. BOBROV, N. GRETSKAYA, O. PAYET, V. BEZUGLOV, T. DURAND, L. MAURIN, F. TOUREL, O. ADJALI, M. RINALDI-CARMONA, A. MULLER, Life Sciences 2005, 77, 1425-1440
  • « B1-phytoprostanes trigger plant defense and detoxification responses. » C. LOEFFLER, S. BERGER, A. GUY, T. DURAND, G. BRINGMANN, U VON RAD, J. DURNER, M.J. MUELLER, Plant Physiol. 137, 328-340 (2005).
  • « A Flexible Synthesis of the Phytoprostanes B1 Types I an II », S. EL FANGOUR, A. GUY, J-P. VIDAL, J-C ROSSI, T. DURAND, J. Org. Chem 70, 989-997 (2005).
  • « Isoprostanes 15-F2t-IsoP and 5-F2t-IsoP are not triggers of myocardial preconditioning. » C. ARNAUD, J-L. CRACOWSKI, A. HAKIM, T. DURAND, A. GUY, D. GODIN-RIBUOT, G. BESSARD, C. RIBUOT, Clin. Ex. Pharmacol. P. 32, 350-354 (2005).
  • « Enzymatic kinetic resolution of a functionalized 4-hydroxy-cyclopentenone : Synthesis of the key intermediates in the total synthesis of Isoprostanes. » E. PINOT, A. GUY, A-L. GUYON, J-C. ROSSI, T. DURAND, Tetrahedron Asymmetry. 16, 1893-1895(2005).
  • « Les Isoprostanes, Biomarqueurs de Peroxydation Lipidique chez l’Homme : Partie 1 : Nomenclature et Synthèse », T. DURAND, J-L. CRACOWSKI, O. BERDEAUX, Pathol. Biol. 53, 349-355 (2005).
  • « Les Isoprostanes, Biomarqueurs de Peroxydation Lipidique chez l’Homme : Partie 2 : Méthodes de Quantification », O. BERDEAUX, O. SCRUEL, T. DURAND, J-L. CRACOWSKI, Pathol. Biol. 53, 356-363, (2005).
  • « Les Isoprostanes, Biomarqueurs de Peroxydation Lipidique chez l’Homme : Partie 3 : Biomarqueurs et Médiateurs en Physiologie et Pathologie Vasculaire. » J-L. CRACOWSKI, O. BERDEAUX, T. DURAND, Pathol. Biol.53, 364-368 (2005).
  • « Synthesis of a potential photoactivatable anandamide analog », L. Balas, M. G. Cascio, V. Di Marzo and T. Durand, Bioorg Med Chem Lett 2006, 16, 3765-3768.
  • « F2-Isoprostanes : Review of Analytical Methods », O. Berdeaux, O. Scruel, J.-L. Cracowski and T. Durand, Current Pharmaceutical Analysis 2006, 2, 69-78.
  • « Cardiovascular pharmacology and physiology of the isoprostanes », J. L. Cracowski and T. Durand, Fundam Clin Pharmacol 2006, 20, 417-427.
  • « Asymmetric conformational changes in a GPCR dimer controlled by G-proteins », M. Damian, A. Martin, D. Mesnier, J. P. Pin and J. L. Baneres, Embo J 2006, 25, 5693-5702.

« Impact of diabetic polyneuropathy and cardiovascular autonomic neuropathy on the excretion of urinary 8-epi-PGF2alpha and its metabolites (2, 3-dinor and 2, 3-dinor-5, 6-dihydro) », J. Nourooz-Zadeh, C. G. Sohr, T. Durand and D. Ziegler, Free Radic Res 2006, 40, 723-729.

« Development of the first potential covalent inhibitors of anandamide cellular uptake », A. Schiano Moriello, L. Balas, A. Ligresti, M. G. Cascio, T. Durand, E. Morera, G. Ortar and V. Di Marzo, J Med Chem 2006, 49, 2320-2332.

« Potent antimalarial activity of 2-aminopyridinium salts, amidines, and guanidines », M. Calas, M. Ouattara, G. Piquet, Z. Ziora, Y. Bordat, M. L. Ancelin, R. Escale and H. Vial, J Med Chem 2007, 50, 6307-6315.

« Ibogaine and noribogaine : structural analysis and stability studies. Use of LC-MS to determine alkaloid contents of the root bark of Tabernanthe iboga », V. Kontrimaviciute, O. Mathieu, L. Balas, R. Escale, J. P. Blayac and F. M. M. Bressolle, Journal of Liquid Chromatography & Related Technologies 2007, 30, 1077-1092.

« Pharmacological actions of isoprostane metabolites and phytoprostanes in human and bovine pulmonary smooth muscles », C. Liu, T. Tazzeo, A. Guy, T. Durand and L. J. Janssen, Prostaglandins Leukot Essent Fatty Acids 2007, 76, 57-64.

« Synthesis and antimalarial activity of new 1,12-bis(N,N’-acetamidinyl)dodecane derivatives », M. Ouattara, S. Wein, M. Calas, Y. Vo-Hoang, H. Vial and R. Escale, Bioorg. Med. Chem. Lett. 2007, 17, 593-596.

« Beyond prostaglandins - Chemistry and biology of cyclic oxygenated metabolites formed by free-radical pathways from polyunsaturated fatty acids », U. Jahn, J. M. Galano and T. Durand, Angewandte Chemie-International Edition 2008, 47, 5894-5955.

« Quantification of urinary F2-isoprostanes with 4(RS)-F4t-neuroprostane as an internal standard using gas chromatography-mass spectrometry Application to polytraumatized patients », E. Mas, F. Michel, A. Guy, V. Bultel, Y. Falquet, P. Chardon, J. C. Rossi, J. P. Cristol and T. Durand, J Chromatogr B Analyt Technol Biomed Life Sci 2008, 872, 133-140.

« Stereocontrolled Access to Isoprostanes via a Bicyclo[3.3.0]octene Framework », C. Oger, Y. Brinkmann, S. Bouazzaoui, T. Durand and J. M. Galano, Organic Letters 2008, 10, 5087-5090.

« Total Synthesis of the Four Enantiomerically Pure Diasteroisomers of the Phytoprostanes E(1)Type II and of the 15-E(2t)-Isoprostanes », E. Pinot, A. Guy, A. Fournial, L. Balas, J. C. Rossi and T. Durand, J Org Chem 2008, 73, 3063-3069.

« Total synthesis of 4-F3t-neuroprostane and its 4-epimer », A.-L. Auvinet, B. Eignerová, A. Guy, M. Kotora and T. Durand, Tetrahedron Lett. 2009, 50, 1498-1500.

« Total synthesis of photoactivatable or fluorescent anandamide probes : novel bioactive compounds with angiogenic activity », L. Balas, T. Durand, S. Saha, I. Johnson and S. Mukhopadhyay, J. Med. Chem. 2009, 52, 1005-1017.

« Flaxseed oil supplementation increases plasma f1-phytoprostanes in healthy men », A. E. Barden, K. D. Croft, T. Durand, A. Guy, M. J. Mueller and T. A. Mori, J Nutr 2009, 139, 1890-1895.

« N-substituted bis-C-alkyloxadiazolones as dual effectors : efficient intermediates to amidoximes or amidines and prodrug candidates of potent antimalarials », M. Degardin, S. Wein, T. Durand, R. Escale, H. Vial and Y. Vo-Hoang, Bioorg Med Chem Lett 2009, 19, 5233-5236.

« New Bioactive Oxylipins Formed by Non-Enzymatic Free-Radical-Catalyzed Pathways : the Phytoprostanes », T. Durand, V. Bultel-Poncé, A. Guy, S. Berger, M. J. Mueller and J. M. Galano, Lipids 2009, 44, 875-888.

« Measurement of urinary F(2)-isoprostanes by gas chromatographymass spectrometry is confounded by interfering substances », E. Mas, A. Barden, T. Durand, J. M. Galano, K. D. Croft and T. A. Mori, Free Radic Res 2009.

« Design and synthesis of amidoxime derivatives for orally potent C-alkylamidine-based antimalarial agents », M. Ouattara, S. Wein, S. Denoyelle, S. Ortial, T. Durand, R. Escale, H. Vial and Y. Vo-Hoang, Bioorg. Med. Chem. Lett. 2009, 19, 624-626.

« Reverse-benzamidine antimalarial agents : Design, synthesis, and biological evaluation », O. Berger, S. Wein, J. F. Duckert, M. Maynadier, S. E. Fangour, R. Escale, T. Durand, H. Vial and Y. Vo-Hoang, Bioorg Med Chem Lett 2010, 20, 5815-5817.

« Total Synthesis of 15-D-2t- and 15-epi-15-E-2t-Isoprostanes », Y. Brinkmann, C. Oger, A. Guy, T. Durand and J. M. Galano, J. Org. Chem. 2010, 75, 2411-2414.

« A cautionary note on the correct structure assignment of phytoprostanes and the emergence of a new prostane ring system », U. Jahn, J. M. Galano and T. Durand, Prostaglandins Leukotrienes and Essential Fatty Acids 2010, 82, 83-86.

« Measurement of urinary F-2-isoprostanes by gas chromatography-mass spectrometry is confounded by interfering substances », E. Mas, A. Barden, T. Durand, J. M. Galano, K. D. Croft and T. A. Mori, Free Radic. Res. 2010, 44, 191-198.

« The omega-3 fatty acids EPA and DHA decrease plasma F(2)-isoprostanes : Results from two placebo-controlled interventions », E. Mas, R. J. Woodman, V. Burke, I. B. Puddey, L. J. Beilin, T. Durand and T. A. Mori, Free Radic Res 2010, 44, 983-990.

« The Handy Use of Brown’s P2-Ni Catalyst for a Skipped Diyne Deuteration : Application to the Synthesis of a D4 Labeled F(4t)-Neuroprostane », C. Oger, V. Bultel-Ponce, A. Guy, L. Balas, J. C. Rossi, T. Durand and J. M. Galano, Chemistry, a european journal 2010, 16, 13976-13980.

« New Insight in Lipase-Catalyzed Regioselective Monoacetylation of Unsymmetrical 1,5-Primary Diols », C. Oger, Z. Marton, Y. Brinkmann, V. Bultel-Poncé, T. Durand, M. Graber and J. M. Galano, J. Org. Chem. 2010, 75, 1892-1897.

« Synthesis and Evaluation of Hybrid Bis-cationic Salts as Antimalarial Drugs », S. Ortial, S. Denoyelle, S. Wein, O. Berger, T. Durand, R. Escale, A. Pellet, H. Vial and Y. Vo-Hoang, Chemmedchem 2010, 5, 52-55.

« Rapid access to structured triacylglycerols acylated with n-3 polyunsaturated fatty acids for nutritional applications », E. Vaique, A. Guy, L. Couedelo, I. Gosse, T. Durand, M. Cansell and S. Pinet, Tetrahedron 2010, 66, 8872-8879.

« Isoprostanes and phytoprostanes : Bioactive lipids », T. Durand, V. Bultel-Ponce, A. Guy, S. El Fangour, J. C. Rossi and J. M. Galano, Biochimie 2011, 93, 52-60.

« Symmetrical choline-derived dications display strong anti-kinetoplastid activity », H. M. Ibrahim, M. I. Al-Salabi, N. El Sabbagh, N. B. Quashie, A. A. Alkhaldi, R. Escale, T. K. Smith, H. J. Vial and H. P. de Koning, J Antimicrob Chemother 2011, 66, 111-125.

« Pharmacokinetic properties and metabolism of a new potent antimalarial N-alkylamidine compound, M64, and its corresponding bioprecursors », D. Margout, F. Gattacceca, G. Moarbess, S. Wein, C. Tran van Ba, S. Le Pape, O. Berger, R. Escale, H. J. Vial and F. M. Bressolle, Eur J Pharm Sci 2011, 42, 81-90.

Actes de colloques (avec comité de lecture)

1- « General Review on the Synthesis of Isoprostanes and Analogs », T. DURAND, A. GUY, J-P. VIDAL, J-C. ROSSI, Prostaglandins Leukot Essent Fatty Acids 71, 33-35 (2004)

2- « Total Synthesis of Iso-and Neuroprostanes : biomarkers of lipid peroxidation. », A. GUY, A. FOURNIAL, S. BERNAD, O. HENRY, J-P. VIDAL, J-C. ROSSI, T. DURAND, Prostaglandins Leukot Essent Fatty Acids 71, 49-50 (2004).

3- « Total Synthesis of Phytoprostanes F1 type I and II », S. EL FANGOUR, A. GUY, V. DESPRES, J-P. VIDAL, J-C. ROSSI, T. DURAND, Prostaglandins Leukot Essent Fatty Acids 71, 50-51 (2004).

4- « Total Synthesis of Phytoprostanes B1 », S. EL FANGOUR, A. GUY, J-P. VIDAL, J-C. ROSSI, T. DURAND, Prostaglandins Leukot Essent Fatty Acids 71, 51-52 (2004).

Articles généraux, revues

Beyond prostaglandins—chemistry and biology of cyclic oxygenated metabolites formed by free-radical pathways from polyunsaturated fatty acids, U. Jahn, J. M. Galano, T. Durand, Angew. Chem. Int. Ed. 47 (2008) 5894-955.

« Radical Cyclization of highly functionalized 1-susbtituted-2,4-dihydroxylated-hex-5-enyl radicals : Useful tools for the synthesis of Iso-and Neuroprostanes. » T. DURAND, A. GUY, O. HENRY, A. ROLAND, S. BERNAD, J-P. VIDAL AND J-C ROSSI, Recent Res. Devel. Organic Chem., 6 (Part II), 521-530 (2002).

Brevets

H.J. VIAL, M. CALAS, R. ESCALE, V. VIDAL-SAILHAN, F. BRESSOLLE, M.L. ANCELIN, Composés à activités antiparasitaires et médicaments les contenant. Applied by CNRS, N° 0209156, July, 18, 2002, PCT/FR03/02283, July, 18, 2003, WO 2004/009068. Patent and know how in the field of human health have been licenced to Sanofi Synthelabo, Dec 2002.

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