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Séminaire Chimie ED459

Amphiphilic glycopolypeptides : bioinspired glycoprotein analogue micellar self-assemblies

Dr. Colin Bonduelle (LCC Laboratoire de Chimie de Coordination, CNRS UPR 8241, Toulouse)

publié le

Le Jeudi 09 juillet 2015 à 13h45
UM FdS salle de cours SC-16.01 (campus Triolet)

Co-authors :
Colin Bonduelle,[a] Jin Huang,[b] Andreas Heise,[b] Sébastien Lecommandoux[a]
[a] Université de Bordeaux/IPB, ENSCBP, 16 avenue Pey Berland, 33607 Pessac Cedex, France. CNRS, Laboratoire de Chimie des Polymères Organiques (UMR5629), Pessac, France.
[b] School of Chemical Sciences, Dublin City University, Dublin 9, Ireland.

Glycopolymers with pendant carbohydrates on a polypeptide backbone, therefore named glycopolypeptides, are a new class of biomimetic materials inspired by natural glycoproteins.[1] The preparation of these polymers involves recent progresses made with N-carboxyanhydride (NCA) controlled ring-opening polymerization (ROP) as well as efficient chemical ligation (“click chemistry”).[1] The purpose of synthetic glycopolypeptides is to mimic the chemical structure of glycoproteins to better understand, by using a simplified model, physicochemical or biological properties of natural glycoproteins and then, to take advantage of the fundamental principles of their structure–function relationships. Herein, we present the synthesis of amphiphilic glycopolypeptides incorporating galactose[2] or iminosugar inhibitors[3]. These biomimetic materials have presented interesting self-assembly behaviors in solution leading to various nanoparticles with sizes below 100 nm that have evidenced remarkable multivalency properties with sugar binding proteins.

[See figure in attached PDF abstract]


1. C. Bonduelle, S. Lecommandoux, Biomacromolecules, 2013, 14, 2973-2983.
2. J. Huang, C. Bonduelle, J. Thevenot, S. Lecommandoux, A. Heise, J. Amer. Chem. Soc., 2012, 134, 119-122.
3. C. Bonduelle, J. Huang, T. Mena Barragan, C. Ortiz Mellet, C. Decroocq, E. Etamé, A. Heise, P. Compain, S. Lecommandoux, Chem. Commun., 2014, 50, 3350-3352.

Contact local IBMM : Sébastien Ulrich


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