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Continuous flow metathesis or how to prepare 10g in 37 min of a key intermediate against Alzheimer’s disease

par corneille - publié le , mis à jour le

For the first time in continuous flow, the Green Chemistry and Enabling Technologies research group from the Institute of Biomolecules Max Mousseron performed ruthenium-catalyzed ring-closing metathesis with great efficiency and in an environmentally friendly solvent, dimethyl carbonate. Thus, only 37 minutes are required to convert 10 grams of diene substrate into a key dihydro-pyrrole intermediate.

This work, financed by the Carnot Chimie Balard Cirimat Institute (ANR program n° 11 CARN 0001-01), the University of Montpellier and the CNRS, is connected to a collaboration with researchers from the Jagiellonian University of Cracow (Poland), dealing with the synthesis of pyrroloquinoline compounds with high therapeutic potential in the fields of Alzheimer’s disease or depression, and was published in the journal Green Chemistry (DOI : 10.1039/C7GC00235A).

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