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Séminaire Chimie ED459

Engineering polymeric nano-micelles for controlled drug delivery

Prof. Dhanjay Jhurry (ANDI Centre of Excellence for Biomedical and Biomolecular Research, University of Mauritius, Réduit, Mauritius)

publié le

Le Jeudi 23 février 2012 à 13h45
UM2, salle de cours SC-16.01

Nanoparticle sustained drug delivery systems offer several advantages over conventional delivery such as maintenance of optimum therapeutic concentration of drug in the blood or cell, elimination of frequent dosing and better patient compliance. Consequently, they are good candidates for more efficient drug release devices. As block copolymer micelles attract increased interest as drug nanocarriers, there is a growing need for tailor-made biodegradable polymers whose size and surface properties can be intelligently designed not only to achieve long circulation times in the blood and site-specific drug delivery but also to exploit physiological or biochemical features of infectious diseases. For instance, only a few studies report on the use of block copolymer micelles to encapsulate anti-TB drugs.

Our research has focused on engineering novel amphiphilic block copolymers based on biodegradable synthetic polymers or biopolymers. We have developed a new family of biodegradable poly(ester-ether)s and coupled them with PEG.[1,2] The resulting copolymers self-assemble into nanometric spherical micelles and have proved quite promising for the loading and sustained release of a number of anti-infectious, anti-inflammatory or anti-cancer drugs.[3]

PolyLysine-b-caprolactone copolymers are another type of ABCs developed by my group. The amino groups of lysine can be interesting for targeting or drug-conjugation. They form nanometric micelles in solution and have been loaded up to 70% with anti-TB rifampicin drug.[4]

The group also engineered graft copolymers based on marine polysaccharides. Indeed, agarose-based systems present the unique advantage of having galactose end groups, which can play a key role in cell targeting. Our oligoagarose-g-polycaprolactone copolymers organize into spherical micelles. An increase in PCL length leads to higher drug loading while sustained drug release was found to be faster with shorter PCL chains.[5]

The design of these different systems and their efficacy as drug delivery devices will be discussed during the presentation.

References

1. Lochee Y, Bhaw-Luximon A, Jhurry D, Kalangos A, Macromolecules 2009, 42, 7285-7291.
2. Lochee Y, Jhurry D, Bhaw-Luximon A, Kalangos A, Polymer International 2010, 59, 1310-1318.
3. Jeetah R, Lochee Y, Bhaw-Luximon A, Jhurry D, submitted, 2011.
4. Veeren A, Bhaw-Luximon A, submitted, 2011.
5. Bhaw-Luximon A, Musharat Meeram L, Jugdawa Y, Helbert W, Jhurry D, Polymer Chemistry 2011, 2, 77-79.

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