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Séminaire Chimie ED459

Glycosaminoglycans – The new frontier of bioanalytical chemistry

Prof. Paul Dubin (Department of Chemistry, University of Massachusetts Amherst, USA)

publié le , mis à jour le

Le Jeudi 19 Mars 2009 à 13h45
UM2, Salle de cours SC-16.01

Glycosaminoglycans (GAG’s) are intensely sulfated polysaccharides, ubiquitous in numerous tissues, epithelial surfaces and in the extracellular matrix, where they modulate all cell biology that involves signaling proteins, including cell differentiation, cell proliferation and angiogenesis. They are implicated in tumor suppression, inflammation, amyloidosis, inhibition of metastasis, and fertilization. While all of these are known to involve protein binding, structure-function relationships for GAG’s are unknown. This is because structural analysis is confounded by the infinite heterogeneity of GAG’s. The question of the biofunctionality of GAG heterogeneity has led to both denial and fascination, as GAG saccharide sequences appear to be random, but subject to genetic control.

Analytical chemistry has a central role to play in this mystery, but this 公案 (ko-an : « paradox ») demands – both as essential, new paradigms and new methods.

N.B. Les personnes souhaitant rencontrer le Prof. Paul Dubin lors de sa visite à Montpellier, sont invitées à contacter rapidement Hervé Cottet, courriel :


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