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Séminaire Chimie ED459

Lipid peroxidation of polyunsaturated fatty acids and its relevance to isoprostanoids and isofuranoids generation in biochemical science

Dr. Chung-Yung Jetty Lee (School of Biological Sciences, University of Hong Kong / Prof. invité UM1)

publié le , mis à jour le

Le Jeudi 11 septembre 2014 à 13h45
UM2, Salle de cours SC-12.01

Lipid peroxidation of polyunsaturated fatty acids occurs ex vivo and in vivo. It can be mediated by free radicals or by enzymes to produce metabolites, which can be robust biomarker of oxidative stress and prognostic compounds of chronic diseases. Previously it is known oxidized metabolites from non-enzymatic free radical reaction of omega-6 arachidonic acid such as 15-F2t-isoprostanes is the best biomarker in determining oxidative stress status in all living systems. However recently it was shown other isoprostanoids and isofuranoids metabolites of omega-6 adrenic, and omega-3 eicosapentaenoic and docosahexaenoic acids have a vital role in neurodegeneration. In order to assess these metabolites, novel compounds synthesized by organic chemists are required, and sensitive instrumentations mainly GC-MS or LC-MS/MS is needed to validate the existence of them in biological systems. In this seminar, the method of measurement and the role of these metabolites in human and other novel biological systems will be presented.

Contact local IBMM : Dr. Thierry Durand (équipe Lipides Bioactifs)


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