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Séminaire Chimie ED459

Meldrum’s acid, a useful platform for the organocatalyzed synthesis of heterocycles

Dr. Jean-François Brière, D.R. CNRS (Laboratoire COBRA, UMR 6014 CNRS, INSA et Université de Rouen-Normandie)

publié le , mis à jour le

SÉMINAIRE ANNULÉ et reporté à une date ultérieure
Le Jeudi 09 Janvier 2020 à 14h
ENSCM, Amphithéâtre Godechot (campus Balard, 240 av. Émile-Jeanbrau)

The development of catalysts or catalytic systems able to accelerate the construction of molecular architectures is at the heart of modern organic synthesis connected to sustainable chemistry. Our research tackles the organocatalytic elaboration of high value chiral heterocycle derivatives, as useful building blocks for the construction of medicinally relevant compounds through the exploration of the 3D chemical space (see http://www.lab-cobra.fr).

More recently, we have been investigating the specific chemical reactivity of Meldrum’s acid, a cheap and readily available starting material. In that context, it was found that Meldrum’s acid derivatives may be involved into either annulation reactions (as a C2-synthon), or multicomponent reactions (as a C3-synthon) by means of organocatalytic and enantioselective reaction conditions.

Contact local IBMM : Prof. Michaël Smietana (DACAN)

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