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Séminaire Chimie IBMM

Nucleoside analogues, biophysical and biological applications : synthesis and development of new bioactive molecules to overcome drug resistance in oncology

Dr. Rachid Benhida, D.R. CNRS (ICN Institut de Chimie de Nice – UMR 7272 CNRS, Université de Nice)

publié le , mis à jour le

Le Jeudi 11 décembre 2014 à 10h
UM2, Amphithéâtre A-5.05 (bâtiment 5)

Drug resistance is a major obstacle that limits the effectiveness of cancer therapy. Many cancer cells acquire resistance mechanisms that allow them to survive apoptosis, contributing to initiation and progression of cancers. Therefore, novel therapeutic strategies are of great interest to address the emerging problem of drug resistance. Recent studies have suggested that the induction of autophagy, another type of cellular death mechanism different from apoptosis, could be a useful therapeutic approach to overcome drug resistance of cancers to some therapeutic agent, particularly those that typically induce an apoptotic response. However, the functional relationship between apoptosis and autophagy is extremely complex, and the molecular machinery is still obscure. Herein we report the first example of new bioactive molecules that modulate the balance between apoptosis and autophagy pathways. The synthesis and biological data on both sensitive and resistant cell lines (CML, MDS and pancreatic carcinoma) will be presented.

Keywords : nucleosides ; RNA ligands ; new biological targets ; drug resistance ; oncology.

Contact local IBMM : Dr. Sébastien Ulrich (équipe Glycochimie)

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