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Publications (2012-present)

par Sebastien Ulrich - publié le , mis à jour le


Self-assembled porphyrin–peptide cages for photodynamic therapy, C. Ghosh, L. M. A. Ali, Y. Bessin, S. Clément, S. Richeter, N. Bettache, S. Ulrich, Org. Biomol. Chem., 2024, DOI 10.1039/D3OB01887C. link

Dynamic covalent synthesis, F. B. L. Cougnon, A. R. Stefankiewicz, S. Ulrich, Chem. Sci., 2024, 15, 879-895. link


If order can be, order will be - Retour sur les 2es Journées de Chimie Supramoléculaire, D. Bourgeois, S. Ulrich, L’Actualité Chimique, 2023, 487, 4-5. link

Bis-Alkylureido Imidazole Artificial Water Channels, D.-D. Su, S. Ulrich, M. Barboiu, Angew. Chem. Int. Ed., 2023, 62, 35, e202306265. link

Nucleic-Acid-Templated Synthesis of Smart Polymer Vectors for Gene Delivery, J. García Coll, S. Ulrich, ChemBioChem, 2023, 24, 19, e202300333. link

A triazolium-anchored self-immolative linker enables self-assembly-driven siRNA binding and esterase-induced release, S. Hollstein, L. M. A. Ali, M. Coste, J. Vogel, N. Bettache, S. Ulrich, M. von Delius, Chem. Eur. J., 2023, 29, 8, e202203311. link

Complexation Preferences of Dynamic Constitutional Frameworks as Adaptive Gene Vectors, D. Su, V. Gervais, S. Ulrich, M. Barboiu, Chem. Eur. J., 2023, 29, 8, e202203062. link

Structure-Activity Relationships in Nucleic-Acid-Templated Vectors Based on Peptidic Dynamic Covalent Polymers, D. Su, L. M. A. Ali, M. Coste, N. Laroui, Y. Bessin, M. Barboiu, N. Bettache, S. Ulrich, Chem. Eur. J., 2023, 29, 7, e202202921. link


Fluorescent Dynamic Covalent Polymers for DNA Complexation and Templated Assembly, C. Kotras, M. Leclercq, M. Roger, C. Bouillon, A. Recupido, A. Lebrun, Y. Bessin, P. Gerbier, S. Richeter, S. Ulrich, S. Clément, M. Surin, Molecules, 2022, 27 (19), 6648. link

Squalene–polyethyleneimine–dynamic constitutional frameworks enhancing the enzymatic activity of carbonic anhydrase, D. Su, K. Aissou, Y. Zhang, V. Gervais, S. Ulrich, M. Barboiu, Catal. Sci. Technol., 2022, 12, 3094-3101. link

Quadruple Functionalization of a Tetraphenylethylene Aromatic Scaffold with Ynamides or Tetracyanobutadienes : Synthesis and Optical Properties, C. Philippe, M. Coste, Y. Bretonnière, L. Lemiègre, S. Ulrich, Y. Trolez, Eur. J. Org. Chem., 2022, e202200049. link

Hierarchical Self-Assembly of Aromatic Peptide Conjugates into Supramolecular Polymers : it takes two to tango, M. Coste, E. Suárez-Picado, S. Ulrich, Chem. Sci., 2022, 13, 909-933. link.

Hierarchical self-assembly and multi-dynamic responsiveness of fluorescent dynamic covalent networks forming organogels, E. Suárez-Picado, M. Coste, J.-Y. Runser, M. Fossépré, A. Carvalho, M. Surin, L. Jierry, S. Ulrich, Biomacromolecules, 2022, 23, 1, 431-442. link.


Constitutional Dynamic Inhibition/Activation of Carbonic Anhydrases, D. Su, Y. Zhang, S. Ulrich, M. Barboiu, ChemPlusChem, 2021, 86, 11, 1500-1510. link.

Perspectives on the Classical Enzyme Carbonic Anhydrase and the Search for Inhibitors. A. Angeli, F. Carta, A. Nocentini, J-Y. Winum, R. Zalubovskis, A. Akdemir, V. Onnis, W.M. Eldehna, C. Capasso, G.De Simone, S.M. Monti, S. Carradori, W.A. Donald, S. Dedhar, C.T. Supuran, Biophysical Journal, 2021, 120, 178-181. link

Design, Implementation, and Evaluation of a Game-based Application for Aiding Chemical Engineering and Chemistry Students to Review the Organic Reactions. J.N. Da Silva Junior, M.A. Sousa Lima, A. Torres Ávila Pimenta, F. Miranda Nunes, A. Carvalho Monteiro, U. Silva De Sousa, A.J. Melo Leite Junior, D. Zampieri, A.F. Serra Oliveira, N.L. Pacioni, J-Y. Winum, Educ. Chem. Eng. , 2021, 34, 106-114. link

Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase. A. Nocentini, A. Angeli, F. Carta, J-Y. Winum, R. Zalubovskis, S. Carradori, C. Capasso, W.A. Donald, C.T. Supuran, J. Enzyme Inhib. Med. Chem., 2021, 36, 561-580. link

Synthesis, self-assembly and nucleic acid recognition of an acylhydrazone-conjugated cationic tetraphenylethene ligand, M. Coste, C. Kotras, Y. Bessin, V. Gervais, D. Dellemme, M. Leclercq, M. Fossépré, S. Richeter, S. Clément, M. Surin, S. Ulrich, Eur. J. Org. Chem., 2021, DOI 10.1002/ejoc.202001420. link

Cell‐selective siRNA delivery using glycosylated dynamic covalent polymers self‐assembled in situ by RNA‐templating, N. Laroui, M. Coste, D. Su, L. Ali, Y. Bessin, M. Barboiu, M. Gary-Bobo, N. Bettache, S. Ulrich, Angew. Chem. Int. Ed., 2021, DOI 10.1002/anie.202014066. link


Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series. A. Aspatwar, N-K. Parvathaneni, H. Barker, E. Anduran, C-T. Supuran, L. Dubois, P. Lambin, S. Parkilla, J-Y. Winum, J. Enzyme Inhib. Med. Chem., 2020, 35, 109-117. link

Targeting the Human 80S Ribosome in Cancer : From Structure to Function and Drug Design for Innovative Adjuvant Therapeutic Strategies. A. Gilles, L. Frechin, K. Natchiar, G. Biondani, O.V. Loeffelholz, S. Holvec, J-L. Malaval, J-Y. Winum, B.P. Klaholz, J-F. Peyron, Cells, 2020, 9, 629. link

Hypoxia-Activated Prodrug Derivatives of Carbonic Anhydrase Inhibitors in Benzenesulfonamide Series : Synthesis and Biological Evaluation. E. Anduran, A. Aspatwar, N-K. Parvathaneni, D. Suylen, S. Bua, A. Nocentini, S. Parkkila, C-T. Supuran, L. Dubois, P. Lambin, J-Y. Winum, Molecules, 2020, 25, 2347. link

Breakthroughs in Medicinal Chemistry : New Targets and Mechanisms, New Drugs, New Hopes-7. M, Gütschow, J-J.V.Eynde, J. Jampilek, C. Kang, A.A. Mangoni, P. Fossa, R. Karaman, A. Trabocchi, P.J.H. Scott, J. Reynisson, S. Rapposelli, S. Galdiero, J-Y. Winum, C. Brullo, K. Prokai-Tatrai, A.K. Sharma, M. Schapira, Y.T. Azuma, L. Cerchia, M. Spetea, G. Torri, S. Collina, A. Geronikaki, A.T. García-Sosa, M.H. Vasconcelos, M.E. Sousa, I. Kosalec, T. Tuccinardi, I.F. Duarte, J.A.R. Salvador, M. Bertinaria, M. Pellecchia, J. Amato, G. Rastelli, P.A.C. Gomes, R.C. Guedes, J-M. Sabatier, A. Estévez-Braun, B. Pagano, S. Mangani, R. Ragno, G. Kokotos, M. Brindisi, F.V. González, F. Borges, M. Miloso, J. Rautio, D. Muñoz-Torrero, Molecules, 2020, 25, 2968. link

Reactions : An Innovative and Fun Hybrid Game to Engage the Students Reviewing Organic Reactions in the Classroom. J.N. Da Silva Júnior, M.A. Sousa Lima, U. Silva De Sousa, D. Macedo Do Nascimento, A.J. Melo Leite Junior, K. Benedetti Vega, B. Roy, J-Y. Winum, J. Chem. Educ., 2020, 97, 749-753. link

Benzoxaboroles : New Potent Inhibitors of the Carbonic Anhydrases of the Pathogenic Bacterium Vibrio cholerae. A. Bonardi, A. Nocentini, R. Cadoni, S. Del Prete, P. Dumy, C. Capasso, P. Gratter, C-T. Supuran, J-Y. Winum, ACS Med. Chem. Lett., 2020, 11, 2277-2284. link

Interactions 500 : Design, Implementation, and Evaluation of a Hybrid Board Game for Aiding Students in the Review of Intermolecular Forces During the COVID-19 Pandemic. J.N. Da Silva Junior, J.M. De Sousa Oliveira, J-Y. Winum, A.J. Melo Leite Junior, A.F. Serra Oliveira, D. Macedo Do Nascimento, U. Silva De Sousa, A. Torres Ávila Pimenta, A. Jalles Monteiro, J. Chem. Educ. , 2020, 97, 4049-4054. link

Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment. A. Angeli, F. Carta, A. Nocentini, J-Y. Winum, R. Zalubovskis, A. Akdemir, V. Onnis ; W.M. Eldehna, C. Capasso, G. De Simone, S.M. Monti, S. Carradori, W.A. Donald, S. Dedhar, C.T. Supuran, Metabolites, 2020, 10, 412. link

A Novel Inhibitor of Carbonic Anhydrases Prevents Hypoxia-Induced TNBC Cell Plasticity. A. Sarnella, G. D’avino, B.S. Hill, V. Alterio, J-Y. Winum, C.T. Supuran, G. De Simone, A. Zannetti, Int. J. Mol. Sci., 2020, 21, 8405. link

Cationic Dynamic Covalent Polymers for Gene Transfection, D. Su, M. Coste, A. Diaconu, M. Barboiu, S. Ulrich, J. Mater. Chem. B, 2020, 8, 9385-9403. link

From Interaction to Function in DNA‐Templated Supramolecular Self‐Assemblies, M. Surin, S. Ulrich, ChemistryOpen, 2020, 9, 480-498. link

Dynamic covalent polymers for biomedical applications, Y. Zhang, Y. Qi, S. Ulrich, M. Barboiu, O. Ramström, Materials Chemistry Frontiers, 2020, 4, 489-506. link


Novel Re(I) tricarbonyl coordination compounds based on 2-pyridyl-1,2,3-triazole derivatives bearing a 4-amino-substituted benzenesulfonamide arm : Synthesis, crystal structure, computational studies and inhibitory activity against carbonic anhydrase I, II and IX isoforms. Y. Aimene, R. Eychenne, S. Mallet-Ladeira, N. Saffon, J-Y. Winum, A. Nocentini, C-T. Supuran, E. Benoist, A. Seridi, J. Enzyme Inhib. Med. Chem., 2019, 34, 773-782. link

N-Aryl-N’-ureido-O-sulfamates : Potent and Selective Inhibitors of the Human Carbonic Anhydrase VII Isoform with Neuropathic Pain-Relieving Properties. M. Bozdag, A. Angeli, G. Poli, T. Tuccinardi, S. Selleri, J-Y. Winum, F. Carta, C-T. Supuran, Bioorg. Chem., 2019, 89, 103033. link

Inhibitors of Selected Bacterial Metalloenzymes. R. Zalubovskis, J-Y. Winum, Curr. Med. Chem., 2019, 26, 2690-2714. link

Metalloenzymes as Therapeutic Targets. B. Richichi, G.A. Spyroulias, J-Y. Winum, R. Zalubovskis, Curr. Med. Chem., 2019, 26, 2556-2557. link

Novel method of treating macular degeneration : A patent evaluation (WO2018/107005). C. Capasso, J-Y. Winum, Expert Opin. Ther. Pat., 2019, 29, 749-752. link

Bis-benzoxaboroles : design, synthesis and biological evaluation as carbonic anhydrase inhibitors. A. Larcher, A. Nocentini, C-T. Supuran, J-Y. Winum, A. Van Der Lee, J-J. Vasseur, D. Laurencin, M. Smietana, ACS Med. Chem. Lett., 2019, 10, 1205-1210. link

Exploring benzoxaborole derivatives as carbonic anhydrase inhibitors : structural and computational analysis reveals their conformational variability as a tool to increase enzyme selectivity. E. Langella, V. Alterio, K. D’ambrosio, R. Cadoni, J-Y. Winum, C-T. Supuran, S.M. Monti, G. De Simone, A. Di Fiore, J. Enzyme Inhib. Med. Chem., 2019, 34, 1498-1505. link

Multivalent Carbonic Anhydrases Inhibitors. F. Carta, P. Dumy, C-T. Supuran, J-Y. Winum, Int. J. Mol. Sci., 2019, 20, 5352. link

Breakthroughs in Medicinal Chemistry : New Targets and Mechanisms, New Drugs, New Hopes-6. J-J. Vanden Eynde, A.A. Mangoni, J. Rautio, J. Leprince, Y.T. Azuma, A.T. García-Sosa, C. Hulme, J. Jampilek, R. Karaman, W. Li, P.A.C. Gomes, D. Hadjipavlou-Litina, R. Capasso, A. Geronikaki, L. Cerchia, J-M. Sabatier, R. Ragno, T. Tuccinardi, A. Trabocchi, J-Y. Winum, F.J. Luque, K. Prokai-Tatrai, M. Spetea, M. Gütschow, I. Kosalec, C. Guillou, M.H. Vasconcelos, G. Kokotos, G. Rastelli, M.E. De Sousa, C. Manera, S. Gemma, S. Mangani, C. Siciliano, S. Galdiero, H. Liu, P.J.H. Scott, C. De Los Ríos, L.A. Agrofoglio, S. Collina, R.C. Guedes, D. Muñoz-Torrero, Molecules, 2019, 25, E119. link

Combination of photodynamic therapy and gene silencing achieved through the hierarchical self-assembly of porphyrin-siRNA complexes. N. Laroui, M. Coste, L. Lichon, Y. Bessin, M. Gary-Bobo, G. Pratviel, C. Bonduelle, N. Bettache, S. Ulrich, Int. J. Pharm., 2019, 569, 118585. link

Tuning the Solubility of Self-Assembled Fluorescent Aromatic Cages Using Functionalized Amino Acid Building Blocks. M. Konopka, P. Cecot, S. Ulrich, A. R. Stefankiewicz, Front. Chem., 2019, 7, Article 503. link

A cationic tetraphenylethene as a light-up supramolecular probe for DNA G-quadruplexes. C. Kotras, M. Fossepre, M. Roger, V. Gervais, S. Richeter, P. Gerbier, S. Ulrich, M. Surin, S. Clément, Front. Chem., 2019, 7, Article 493. link

Growing Prospects of Dynamic Covalent Chemistry in Delivery Applications. S. Ulrich, Acc. Chem. Res., 2019, 52, 2, 510-519. Link

(Hetero)aryl substituted thiazol-2,4-yl scaffold as human carbonic anhydrase I, II, VII and XIV activators. M. Rami, J-Y. Winum, C.T. Supuran, P. Melnyk, S. Yous, J. Enzyme Inhib. Med. Chem., 2019, 34, 224-229. Link


Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases : An Update on In Vitro and In Vivo Studies. A. Aspatwar, J-Y. Winum, F. Carta, C.T. Supuran, M. Hammaren, M. Parikka, S. Parkkila, Molecules., 2018, 23(11), E2911. link

Inhibition of carbonic anhydrases by a substrate analog : benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding. G. De Simone, A. Angeli, M. Bozdag, C.T. Supuran, J-Y. Winum, S.M. Monti, V. Alterio, Chem. Commun., 2018, 54(73), 10312-10315. link

Biomolecular Dynamic Covalent Polymers for DNA complexation and siRNA delivery. C. Bouillon, Y. Bessin, F. Poncet, M. Gary-Bobo, P. Dumy, M. Barboiu, N. Bettache, S. Ulrich, J. Mater. Chem. B., 2018, 7239-7246. link

Multivalent metallosupramolecular assemblies as effective DNA binding agents. W. Drożdż, A. Walczak, Y. Bessin, V. Gervais, X.‐Y. Cao, J.‐M. Lehn, S. Ulrich, A. R. Stefankiewicz, Chem. Eur. J., 2018, 24, 10802-10811. link

Auto-assemblages dynamiques pour la reconnaissance et la vectorisation d’acides nucleiques. S. Ulrich, L’Actualité Chimique, 2018, 430-431, 61-67. link

Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes. A. Aspatwar, H.M. Becker, N.K. Parvathaneni, M. Hammaren, A. Svorjova, H. Barker, C.T. Supuran, L. Dubois, P. Lambin, M. Parikka, S. Parkkila, J-Y Winum, J. Enzyme Inhib. Med. Chem., 2018, 33(1), 1064-1073. link

Carbonic anhydrase enzymes for regulating mast cell hematopoiesis and type-2 inflammation : a patent evaluation (WO2017/058370). J-Y Winum, Expert Opin. Ther. Pat., 2018, 28(10), 741-743. link

Benzoxaborole compounds for therapeutic uses : a patent review (2010- 2018). A. Nocentini, C.T. Supuran, J-Y Winum, Expert Opin. Ther. Pat., 2018, 28 (6), 493-504. link

Self-assembly and chiroptical properties in supramolecular complexes of adenosine phosphates and guanidinium-bispyrene. M. Trévisan, M. Fossépré, D. Paolantoni, J. Rubio‐Magnieto, P. Dumy, S. Ulrich, M. Surin, Chirality, 2018, 30 (6), 719-729. link

Inhibitors of Selected Bacterial Metalloenzymes. R. Zalubovskis, J-Y Winum, Curr. Med. Chem., 2018, in press. doi : 10.2174/0929867325666180403154018. link

Switching multivalent DNA complexation using metallo-controlled cationic supramolecular self-assemblies. W. Drożdż, Y. Bessin, V. Gervais, X.-Y. Cao, J.-M. Lehn, A. R. Stefankiewicz, S. Ulrich, Chem. Eur. J., 2018, 24 (7), 1518-1521. link

Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles. A. Nocentini , R. Cadoni, P. Dumy, CT. Supuran, J-Y Winum, J. Enzyme Inhib. Med. Chem., 2018, 33 (1), 286-289. link

Photomodulation of DNA-templated supramolecular assemblies. J. Rubio-Magnieto, T.-A. Phan, M. Fossépré, V. Matot, J. Knoops, T. Jarrosson, P. Dumy, F. Serein-Spirau, C. Niebel, S. Ulrich, M. Surin, Chem. Eur. J., 2018, 24 (3), 706-714. link

Co-targeting intracellular pH and essential amino acid uptake cooperates to induce cell death of T-ALL/LL cells. V. Imbert, M. Nebout, D. Mary, H. Endou, MF. Wempe, CT. Supuran, J-Y. Winum, J-F. Peyron, Leuk. Lymphoma, 2018, 59 (2), 460-468. link


Generation of Multicomponent Molecular Cages using Simultaneous Dynamic Covalent Reactions. W. Drożdż, C. Bouillon, C. Kotras, S. Richeter, M. Barboiu, S. Clément, A. R. Stefankiewicz, S. Ulrich, Chem. Eur. J., 2017, 23, 18010-18018. link

Benzoxaboroles as Efficient Inhibitors of the β-Carbonic Anhydrases from Pathogenic Fungi : Activity and Modeling Study. A. Nocentini, R. Cadoni, S. del Prete, C. Capasso, P. Dumy, P. Gratteri, C.T. Supuran, J-Y. Winum, ACS Med. Chem. Lett., 2017, 8 (11), 1194-1198. link

Polyhedral oligomeric silsesquioxane (POSS) bearing glyoxylic aldehyde as clickable platform towards multivalent conjugates. N. Kanfar, A. Mehdi, P. Dumy, S. Ulrich, J.-Y. Winum, Chem. Eur. J., 2017, 23, 17867-17869. link

One-Pot Self-Assembly of Peptide-Based Cage-Type Nanostructures using Orthogonal Ligations. E. Bartolami, J. Knoops, Y. Bessin, M. Fossépré, J. Chamieh, P. Dumy, M. Surin, S. Ulrich, Chem. Eur. J., 2017, 23, 14323-14331. link

New approach of delivering cytotoxic drugs towards CAIX expressing cells : A concept of dual-target drugs. S. Van Kujik, N-K. Parvathaneni, R. Niemans, MW. Van Gisbergen, F. Carta, D. Vullo, S. Pastorekova, A. Yaromina, C.T. Supuran, L. Dubois, J-Y. Winum, P. Lambin, Eur. J. Med. Chem., 2017, 127, 691-702. link

Brucella suis carbonic anhydrases and their inhibitors : towards alternative antibiotics ? S. Kohler, S. Ouahrani-Bettache, J-Y. Winum, J. Enzyme Inhib. Med. Chem., 2017, 32, 683-687. link

Anion inhibitors of the beta-carbonic anhydrase from the pathogenic bacterium responsible of tularemia, Francisella tularensis. S. Del Prete, D. Vullo, S.M. Osman, Z. Alothman, W.A. Donald, J-Y. Winum, C.T. Supuran, C. Capasso, Bioorg. Med. Chem., 2017, 25 (17), 4800-4804. link

Insights into the binding mode of sulfamates and sulfamides to hCA II : crystallographic studies and binding free energy calculations. G. De Simone, E. Langella, D. Esposito, C.T. Supuran, S.M. Monti, J-Y. Winum, V. Alterio, J. Enzyme Inhib. Med. Chem., 2017, 32, 1002-1011. link

Effective Access to Multivalent Inhibitors of Carbonic Anhydrases Promoted by Peptide Bioconjugation. N. Kanfar, M. Tanc, P. Dumy, C. T. Supuran, S. Ulrich, J.-Y. Winum, Chem. Eur. J., 2017, 23 (28), 6788-6794. link

SuFEx : a metal-free click ligation for multivalent biomolecules. A. Marra, A. Dondoni, Org. Biomol. Chem., 2017, (15), 1549-1553. link

Auto-assemblage dynamique de clusters cationiques pour la complexation et la vectorisation d’acides nucléiques. E. Bartolami, S. Ulrich, P. Dumy, L’Actualité Chimique, 2017, 417. link


DNA Methyltransferase Inhibitors : Development and Applications. M. Lopez, L. Halby, P. B. Arimondo, Advances in Experimental Medicine and Biology, 2016, 945, 431-473. link

« Drug Discovery Methods ». M. Lopez, M. Leroy, C. Etievant, F. Ausseil, A. Gagnon, P. B. Arimondo, In G. Egger & P. Arimondo (Eds), Drug Discovery in Cancer Epigenetics, Elsevier, 2016, 63-95. link

Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution. C. S. Hwang, L. Xu, W. Wang, S. Ulrich, L. Zhang, J. Chong, J. H. Shin, X. Huang, E. T. Kool, C. E. McKenna, D. Wang, Nucl. Acids Res., 2016, 44 (8), 3820-3828. link

Bioactive clusters promoting cell penetration and nucleic acids complexation for drug and gene delivery applications : from designed to self-assembled and responsive systems. E. Bartolami, C. Bouillon, P. Dumy, S. Ulrich, Chem. Commun., 2016, 52, 4257-4273. link

A click ligation based on SuFEx for the metal-free synthesis of sugar and iminosugar clusters. R. Zelli, S. Tommasone, P. Dumy, A. Marra, A. Dondoni, Eur. J. Org. Chem., 2016, 5102-5116. link

Role of a preorganized scaffold presenting four residues of a GM‐3 lactone mimetic on Melanoma progression. B. Richichi, G. Comito, O. Renaudet, M. Fiore, A. Marra, B. Stecca, L. Pasquato, P. Chiarugi, C. Nativi, ACS Med. Chem. Lett., 2016, (7), 28-33. link

A metal-free synthetic approach to peptide-based iminosugar clusters as novel multivalent glycosidase inhibitors. R. Zelli, E. Bartolami, J.-F. Longevial, Y. Bessin, P. Dumy, A. Marra, S. Ulrich, RSC Adv., 2016, 6, 2210-2216. link

The anticonvulsant sulfamide JNJ-26990990 and its S, S - dioxide analog strongly inhibit carbonic anhydrases : kinetic and X-ray crystallographic studies. A. Di Fiore, G. De Simone, V. Alterio, V. Riccio, J-Y. Winum, F. Carta, C-T. Supuran, Org. Biomol. Chem., 2016, 14 (21), 4853-4858. link

Benzoxaborole as a New Chemotype for Carbonic Anhydrase Inhibition. V. Alterio, R. Cadoni, D. Esposito, D. Vullo, A. Di Fiore, Sm. Monti, A. Caporale, M. Ruvo, M. Sechi, P. Dumy, Ct. Supuran, G. De Simone, J-Y. Winum, Chem. Commun., 2016, 52 (80), 11983-11986. link

Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors : a patent evaluation of US20160011199A1. J-Y. Winum, Expert Opin. Ther. Pat., 2016, 26 (11), 1223-1226. link


Compounds for use in the treatment of mycobacterial infections : a patent evaluation (WO2014049107A1). D. Pechalrieu, M. Lopez, Expert Opinion on Therapeutic Patents, 2015, 25 (6), 729-735. link

Emerging trends in enzyme inhibition by multivalent nanoconstructs. N. Kanfar, E. Bartolami, R. Zelli, A. Marra, J.-Y. Winum, S. Ulrich, P. Dumy, Org. Biomol. Chem., 2015, 13, 9894-9906. link

Multivalent DNA recognition by self-assembled clusters : deciphering structural effects by fragments screening and evaluation as siRNA vectors. E. Bartolami, Y. Bessin, N. Bettache, M. Gary-Bobo, M. Garcia, P. Dumy, S. Ulrich, Org. Biomol. Chem., 2015, 13, 9427-9438 (themed collection : Multivalent Biomolecular Recognition). link

Dynamic expression of DNA complexation with self-assembled biomolecular clusters
E. Bartolami, Y. Bessin, V. Gervais, P. Dumy, S. Ulrich, Angew. Chem. Int. Ed., 2015, 54 (35), 10183-10187. link

Synthesis and biological properties of multivalent iminosugars. R. Zelli, J.-F. Longevial, P. Dumy, A. Marra, New J. Chem., 2015, (39), 5050-5074. link

Validating the alkene and alkyne hydrophosphonylation as an entry to organophosphonates. A. Dondoni, A. Marra, Org. Biomol. Chem., 2015, (13), 2212–2215. link

Metal-free synthesis of E-vinylphosphonates via photoinduced alkyne hydrophosphonylation and thiol promoted isomerization sequence. S. Staderini, A. Dondoni, A. Marra Tetrahedron Lett., 2015, (56), 374-377. link

Fluorescent silica nanoparticles with multivalent inhibitory effects towards carbonic anhydrases. N. Touisni, N. Kanfar, S. Ulrich, P. Dumy, C.T. Supuran, A. Mehdi, J.-Y. Winum, Chem. Eur. J., 2015, 21 (29), 10306-10309. link

Synthesis of a-PNA containing a functionalized triazine as nucleobase analogue, E. Bartolami, A. Gilles, P. Dumy, S. Ulrich, Tetrahedron Lett., 2015, 56 (18), 2319-2323. link

A Dynamic Combinatorial Approach for Identifying Side Groups that Stabilize DNA-Templated Supramolecular Self-Assemblies, D. Paolantoni, S. Cantel, P. Dumy, S. Ulrich, Int. J. Mol. Sci., 2015, 16, 3609-3625 (special issue « Supramolecular interactions »). link

Binding of carbonic anhydrase IX to 45s rDNA genes is prevented by exportin-1 in hypoxic cells. E. Sasso, M. Vitale, F. Monteleone, Fl. Boffo, M. Santoriello, D. Sarnataro, C. Garbi, M. Sabatella, B. Crifò, LA. Paolella, G. Minopoli, J-Y. Winum, N. Zambrano, BioMed. Res. Int., 2015, Volume 2015, Article ID 674920, 10 pages. Link

Recent advances in the discovery of zinc binding motifs for the development of carbonic anhydrase inhibitors. J-Y. Winum, CT. Supuran, J. Enzyme Inhib. Med. Chem., 2015, 30, 321-324. Link

Inhibition of β-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moiety. LE. Riafrecha, D. Vullo, S. Ouahrani-Bettache, S. Köhler, P. Dumy, J-Y. Winum, CT. Supuran, PA. Colinas, J. Enzyme Inhib. Med. Chem., 2015, 30, 1017-1020. Link

N-Glycosyl-N-Hydroxysulfamides as Potent Inhibitors of Brucella suis Carbonic Anhydrases. J. Ombouma, D. Vullo, S. Kohler, P. Dumy, CT. Supuran, J-Y. Winum, J. Enzyme Inhib. Med. Chem., 2015, 30, 1010-1012. Link

Designing carbonic anhydrase inhibitors for the treatment of breast cancer. CT. Supuran, J-Y. Winum, Expert Opin. Drug Discov., 2015, 10, 591-597. link

Poly(amidoamine) Dendrimers with Carbonic Anhydrase Inhibitory Activity and Antiglaucoma Action. F. Carta, SM. Osman, D. Vullo, A. Gullotto, J-Y. Winum, Z. Alothman, E. Masini, CT. Supuran, J. Med. Chem., 2015, 58, 4039-4045. Link

Evaluation of Carbonic Anhydrase IX as a Therapeutic Target for Inhibition of Breast Cancer Invasion and Metastasis Using a Series of in vitro Breast Cancer Models. C. Ward, J. Meehan, P. Mullen, CT. Supuran, JM. Dixon, JS. Thomas, J-Y. Winum, P. Lambin, L. Dubois, NK. Pavathaneni, EJ. Jarman, L. Renshaw, I. Um, C. Kay, IH. Kunkler, DJ. Harrison, SP. Langdon, Oncotarget, 2015, 6, 24856-24870. Link=4498&pubmed-linkout=1]

Carbonic Anhydrase Glycoinhibitors belonging to the Aminoxysulfonamide Series. J. Ombouma, D. Vullo, P. Dumy, CT. Supuran, J-Y. Winum, ACS Med. Chem. Lett., 2015, 6, 819-21. Link

Carbonic Anhydrase IX Inhibitors in Cancer Therapy : an Update. CT. Supuran, J-Y. Winum, Future Med. Chem., 2015, 7, 1407-14. link

New ways to image and target tumour hypoxia and its molecular responses. LJ. Dubois, R. Niemans, SJ. Van Kuijk, KM. Panth, NK. Parvathaneni, SG. Peeters, CM. Zegers, NH. Rekers, MW. Van Gisbergen, R. Biemans, NG. Lieuwes, L. Spiegelberg, A. Yaromina, J-Y. Winum, M. Vooijs, P. Lambin, Radiother. Oncol., 2015, 116, 352-357. link


Oxo- and thiooxo-imidazo[1,5-c]pyrimidine molecule library : beyond their interest in inhibition of Brucella suis histidinol dehydrogenase, a powerful protection tool in the synthesis of histidine analogues. F. Turtaut, M. Lopez, S. Ouahrani-Bettache, S. Köhler, J.-Y. Winum, Bioorganic and Medicinal Chemistry Letters, 2014, 24, 5008-5010. link

Synthesis of sulfomanide-conjugated glycosyl-amino acid building blocks. M. Lopez, L. F. Bornaghi and S.-A. Poulsen, Carbohydrate research, 2014, 386, 78-85. link

Structural basis for the rational design of new anti-Brucella agents : the crystal structure of the C366S mutant of HDH from Brucella suis. K. D’ambrosio, M. Lopez, N. A. Dathan, S. Ouahrani-Bettache, S. Köhler, G. Ascione, S. M. Monti, J.-Y. Winum and G. De Simone, Biochimie, 2014, 97, 114-120. link

Probing the importance of π-stacking interactions in DNA-templated self-assembly of bisfunctionalized guanidinium compounds, D. Paolantoni, J. Rubio-Magnieto, S. Cantel, J. Martinez, P. Dumy, M. Surin, S. Ulrich, Chem. Commun., 2014, 50, 14257-14260. link

Degradable Hybrid Materials Based on Cationic Acylhydrazone Dynamic Covalent Polymers Promote DNA Complexation through Multivalent Interactions, C. Bouillon, D. Paolantoni, J. C. Rote, Y. Bessin, L. W. Peterson, P. Dumy, S. Ulrich, Chem. Eur. J., 2014, 20 (45), 14705-14714. link

Probing Secondary Interactions in Biomolecular Recognition by Dynamic Combinatorial Chemistry, S. Ulrich, P. Dumy, Chem. Commun., 2014, 50 (44), 5810-5825 (“Systems chemistry : a web themed issue”). link

Synthesis and glycosidase inhibition properties of triazole-linked calixarene-iminosugar clusters. A. Marra, R. Zelli, G. D’Orazio, B. La Ferla, A. Dondoni, Tetrahedron, 2014, (70), 9387-9393. link

Synthesis of galactoclusters by metal-free thiol « click chemistry » and their binding affinities for Pseudomonas aeruginosa lectin LecA. C. Ligeour, L. Dupin, A. Marra, G. Vergoten, A. Meyer, A. Dondoni, E. Souteyrand, J.-J. Vasseur, Y. Chevolot, F. Morvan, Eur. J. Org. Chem., 2014, 7621-7630. link

Thiol-ene and thiol-yne-based synthesis of glycodendrimers as nanomolar inhibitors of wheat germ agglutinin. M. Ghirardello, K. Öberg, S. Staderini, O. Renaudet, N. Berthet, P. Dumy, Y. Hed, A. Marra, M. Malkoch, A. Dondoni, J. Polym. Sci., Part A : Polym. Chem., 2014, (52), 2422-2433. link

Metal-catalyzed and metal-free alkyne hydrothiolation : Synthetic aspects and application trends. A. Dondoni, A. Marra, Eur. J. Org. Chem., 2014, 3955-3969. link

Theoretical and Structural Analysis of Long C–C Bonds in the Adducts of Polycyanoethylene and Anthracene Derivatives and their Connection to the Reversibility of Diels–Alder Reactions, A. K. H. Hirsch, P. Reutenauer, M. Le Moignan, S. Ulrich, P. J. Boul, J. M. Harrowfield, P. D. Jarowski, J.-M. Lehn, Chem. Eur. J., 2014, 20 (4), 1073-1080. link

Oxime Ligation : a Chemoselective Click-Type Reaction for Accessing Multifunctional Biomolecular Constructs, S. Ulrich, D. Boturyn, A. Marra, O. Renaudet, P. Dumy, Chem. Eur. J., 2014, 20 (1), 34-41. link

Metal-based carboxamide-derived compounds endowed with antibacterial and antifungal activity. M. Hanif, ZH. Chohan, J-Y. Winum, J. Akhtar, J. Enzyme Inhib. Med. Chem., 2014, 29, 517-26. link

Carbonic anhydrase inhibitors. Inhibition of human cytosolic isoforms I and II with (reduced) Schiff’s bases incorporating sulfonamide, carboxylate and carboxymethyl moieties. G. Nasr, A. Cristian, M. Barboiu, D. Vullo, J-Y. Winum, CT. Supuran, Bioorg. Med. Chem., 2014, 22, 2867-74. link

Dominant behaviours in the expression of human of Carbonic Anhydrase hCA I activity. MYM. Abdelarhim, AM. Tanc, J-Y. Winum, CT. Supuran, M. Barboiu, Chem. Commun., 2014, 50, 8043-8046. link

Mono and Di-Halogenated Histamine, Histidine and Carnosine Derivatives are Potent Carbonic Anhydrase I, II, VII, XII and XIV Activators. MC. Saada, D. Vullo, J-L. Montero, A. Scozzafava, CT. Supuran,J-Y. Winum, Bioorg. Med. Chem., 2014, 22, 4752-8. link

Ferrier sulfamidoglycosylation of glycals catalyzed by nitrosononium tetrafluoroborate : towards new carbonic anhydrase glycoinhibitors. J. Ombouma, D. Vullo, CT. Supuran, J-Y. Winum, Bioorg. Med. Chem., 2014, 22, 6353-6359.


Antimalarial activity of compounds comprising a primary benzene sulfonamide fragment. K. T. Andrews, G. M. Fisher, S. D.M. Sumanadasa, T. Skinner-Adams, J. Moeker, M. Lopez and S.-A. Poulsen, Bioorganic and Medicinal Chemistry Letters, 2013, 23 (22), 6114-6117. link

Synthesis of acylated glycoconjugates as templates to investigate in vitro biopharmaceutical properties. C. J. Carroux, J. Moeker, J. Motte, M. Lopez, L. F. Bornaghi, K. Katneni, E. Ryan, J. Morizzi, D. M. Shackleford, S. A. Charman and S.-A. Poulsen, Bioorganic and Medicinal Chemistry Letters, 2013, 23 (2), 455-459. link

Engineering of biomolecules for sensing and imaging applications, S. Ulrich, P. Dumy, D. Boturyn, O. Renaudet, J. Drug Del. Sci. Tech., 2013, 23 (1), 5-15. link

Synthesis of rapamycin glycoconjugates via a CuAAC-based approach. L. Moni, A. Marra, J. S. Skotnicki, F. E. Koehn, M. Abou-Gharbia, A. Dondoni, Tetrahedron Lett., 2013, (54), 6999-7003. link

Tetravalent glycocyclopeptide with nanomolar affinity to wheat germ agglutinin. M. Fiore, N. Berthet, A. Marra, E. Gillon, P. Dumy, A. Dondoni, A. Imberty, O. Renaudet, Org. Biomol. Chem., 2013, (11), 7113-7122. link

Efficiency of the free-radical hydrophosphonylation of alkenes : The photoinduced reaction of dimethyl H-phosphonate with enopyranoses as an exemplary case. A. Dondoni, S. Staderini, A. Marra, Eur. J. Org. Chem., 2013, 5370-5375. link

Multivalent presentation of a hydrolytically stable GM3 lactone mimetic as modulator of melanoma cells motility and adhesion. B. Richichi, G. Comito, L. Cerofolini, G. Gabrielli, A. Marra, L. Moni, A. Pace, L. Pasquato, P. Chiarugi, A. Dondoni, L. Toma, C. Nativi, Bioorg. Med. Chem., 2013, (21), 2756-2763. link

Thiyl glycosylation of propargylated octasilsesquioxane : Synthesis and lectin binding properties of densely glycosylated clusters on a cubic platform. A. Marra, S. Staderini, N. Berthet, P. Dumy, O. Renaudet, A. Dondoni, Eur. J. Org. Chem., 2013, 1144-1149. link

Metronidazole-coumarin conjugates and 3-cyano-7-hydroxy-coumarin act as isoform-selective carbonic anhydrase inhibitors. A. Bonneau, A. Maresca, J-Y. Winum, C.T. Supuran, J. Enzyme Inhib. Med. Chem., 2013,28, 397-401. Link

Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche. F.E. Lock, P. Mcdonald, Y. Lou, C. Ostlund, S. Aparicio, J-Y. Winum, C.T. Supuran, S. Dedhar, Oncogene, 2013, 32, 5210–5219. Link

Glycosidic carbonic anhydrase IX inhibitors : a sweet approach against cancer. J-Y. Winum, P. Colinas, C.T. Supuran, Bioorg. Med. Chem., 2013, 21, 1419-1426. Link

Novel antibody to a carbonic anhydrase (WO2011138279). C. Capasso, J-Y. Winum, Expert Opin. Ther. Pat., 2013, 23, 757-760. Link

A spectrophotometric and thermodynamic study of the charge-transfer complexes of N-aryl-N’-isopropyloxycarbonylsulfamides with DDQ and TCNE. M. Belfaragui, A. Seridi, J-Y. Winum, M. Abdaoui, M. Kadri, Spectrochim. Acta A Mol. Biomol. Spectrosc., 2013, 108, 55-61. Link

Thiol-ene click chemistry for the synthesis of highly effective glycosyl sulfonamide carbonic anhydrase inhibitors. MC. Saada, J. Ombouma, J-L. Montero, CT. Supuran, J-Y. Winum, Chem. Commun., 2013, 49, 5699-701. Link

Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation : A new concept of dual targeting drugs. L. Dubois, SG. Peeters, SJ. Van Kuijk, A. Yaromina, NG. Lieuwes, R. Saraya, R. Biemans, M. Rami, NK. Parvathaneni, D. Vullo, M. Vooijs, CT. Supuran, J-Y. Winum, P. Lambin, Radiother. Oncol., 2013, 108, 523-528. Link

Hypoxia-targeting Carbonic Anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamide /sulfamide/ sulfamate. M. Rami, L. Dubois, NK. Parvathaneni, V. Alterio, S. Van Kujik, S. Monti, P. Lambin, G. De Simone, CT. Supuran, J-Y. Winum, J. Med. Chem., 2013, 56, 8512-8520. Link


Zinc metalloenzymes as new targets against the bacterial pathogen Brucella. M. Lopez, S. Köhler, J.-Y. Winum, Journal of Inorganic Biochemistry, 2012, 111, 138-145. link

Design and synthesis of thiourea inhibitors targeting transmembrane carbonic anhydrases. J. Möker, K. Teruya, S. Rossit, B. L. Wilkinson, M. Lopez, L. F. Bornaghi, A. Innocenti, C. T. Supuran, S.-A. Poulsen, Bioorganic and Medicinal Chemistry, 2012, 20 (7), 2392-2404. link

Chemo-enzymatic Synthesis of Xylogluco-Oligosaccharides and their Interactions with Cellulose. M. Lopez, S. Fort, H. Bizot, A. Buléon, H. Driguez, Carbohydrate polymers, 2012, 88, 185-193. link

Conformational constraints : Nature does it best with sialyl LewisX. A. Titz, A. Marra, B. Cutting, M. Smieško, G. Papandreou, A. Dondoni, B. Ernst, Eur. J. Org. Chem., 2012, 5534-5539. link

Glycoside and peptide clustering around the octasilsesquioxane scaffold via photoinduced free-radical thiol-ene coupling. The observation of a striking glycoside cluster effect. M. Lo Conte, S. Staderini, A. Chambery, N. Berthet, P. Dumy, O. Renaudet, A. Marra, A. Dondoni, Org. Biomol. Chem., 2012, (10), 3269-3277. link

Discussion Addendum for : Diastereoselective homologation of D-(R)-glyceraldehyde acetonide using 2-(trimethylsilyl)thiazole : 2-O-benzyl-3,4-isopropylidene-D-erythrose. A. Dondoni, A. Marra, Org. Synth., 2012, (89), 323-333. link

Free-radical hydrothiolation of glycals : a thiol-ene-based synthesis of S-disaccharides. S. Staderini, A. Chambery, A. Marra, A. Dondoni, Tetrahedron Lett., 2012, (53), 702-704. link

Recent applications of thiol–ene coupling as a click process for glycoconjugation. A. Dondoni, A. Marra, Chem. Soc. Rev., 2012, (41), 573-586. link

Biodistribution and Pharmacokinetic Studies of a Porphyrin Dimer Photosensitizer (Oxdime) by Fluorescence Imaging and Spectroscopy in Mice Bearing Xenograft Tumors, M. Khurana, S. Ulrich, A. Kim, Y. Moriyama, G. Netchev, M. K. Akens, H. L. Anderson, B. C. Wilson, Photochem. Photobiol., 2012, 88, 1531-1538. link

Dissecting Chemical Interactions Governing RNA Polymerase II Transcriptional Fidelity, M. W. Kellinger, S. Ulrich, J. Chong, E. T. Kool, D. Wang, J. Am. Chem. Soc., 2012, 134, 8231-8240. link

Polypharmacology of sulfonamides : pazopanib, a multitargeted receptor tyrosine kinase inhibitor in clinical use, potently inhibits several mammalian carbonic anhydrases. J-Y. Winum, A. Maresca, F. Carta, A. Scozzafava, C.T. Supuran, Chem. Commun., 2012, 48 (66), 8177-8179. link

Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics. P. Mcdonald, J-Y. Winum, C.T. Supuran, S. Dedhar, Oncotarget, 2012, 3, 84-97. Link=422&pubmed-linkout=1]

Inhibition of the beta-carbonic anhydrases from the bacterial pathogen Brucella suis with inorganic anions. A. Maresca, A. Scozzafava, S. Kohler, J-Y. Winum, C.T. Supuran, J. Inorg. Biochem., 2012, 110, 36-39. Link

Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. G. Balboni, C. Congiu, V. Onnis, A. Maresca, A. Scozzafava, J-Y. Winum, C.T. Supuran, Bioorg. Med. Chem. Lett., 2012, 22, 3063-3066. Link

Anti-metastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts. R.G. Gieling, M. Babur, L. Mamnani, N. Burrows, B.A. Telfer, F. Carta, J-Y. Winum, A. Scozzafava, C.T. Supuran, K.J. Williams, J. Med. Chem., 2012, 55, 5591-5600. Link

Ureido-Substituted Sulfamates With Potent Carbonic Anhydrase Ix Inhibitory And Antitumor Activities. J-Y. Winum, F. Carta, C. Ward, P. Mullen, D. Harrison, S. Langdon, A. Cecchi, A. Scozzafava, I. Kunkler, C.T. Supuran, Bioorg. Med. Chem. Lett., 2012, 22, 4681-4685. Link

Development of Potent Carbonic Anhydrase Inhibitors Incorporating Both Sulfonamide And Sulfamide Groups. K. D’ambroso, F-Z. Smaine, F. Carta, G. De Simone, J-Y. Winum, C.T. Supuran, J. Med. Chem., 2012, 55, 6776-6783. Link