(la conférence sera présentée en français)
English title : Synthesis of small molecules targeting entry filovirus inhibition
Ebola virus is the causative agent of one of the most deadly disease. Small molecule inhibitors of the viral polymerase have shown promise but targeting host factors required for viral infection is also a promising alternative strategy. Herein, we will present we took the design and synthesize of a library of small molecules targeting Niemann-Pick C1 protein, cathepsin proteases. In order to obtain efficient cysteine cathepsins inhibitors, we have synthesized various compounds bearing 1,3,5-triazine moiety. For Neimann-Pick C1 inhibitors, we prepared several diversely substituted (in term of size and shape) 1,4-N,N-piperazines. Biological data will be provided.
Contact local IBMM : Dr. Béatrice Roy (DACAN)
Voir en ligne : Site web équipe L. Agrofoglio