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A domino effect…

Controlling the Chair Conformation of a Mannopyranose in a Large- Amplitude [2]Rotaxane Molecular Machine

par corneille - publié le

… from one extremity to the other is observed in a large-amplitude
mannosyl [2]rotaxane molecular machine. In their Communication, F. Coutrot and E. Busseron describe the efficient preparation of new [2]rotaxane
molecular machines containing anilinium and either mono- or disubstituted
pyridinium amide stations.
In the case of the disubstituted pyridinium amide, the macrocycle
shuttles from the anilinium to the pyridinium upon deprotonation
and causes an impressive flipping of the chair conformation of
the glucidic moiety.

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